Sheng et al. discovered a distinct subset of antigen-presenting cells (APCs) that shares the migratory nature and markers (CD11chiMHCIIhiCD11b+CD24+) of conventional cDC2 dendritic cells and the monocytic origin, phagocytic properties, and markers (F4/80hiCD64+CD169+MERTK+) of tissue-resident macrophages. In metastatic melanoma and colorectal cancer mouse models, these “hybrid” APCs were enriched in the tumor microenvironment, and were capable of cross-presenting tumor-derived antigens.
Dendritic cells (DCs) and macrophages share close developmental pathways and functional features, leading to blurring of the boundaries between these two cell lineages. However, a deeper understanding of DC and macrophages ontogeny and more refined phenotypic and functional characterizations have helped to delineate pre-DC-derived conventional DCs (cDCs), including cDC1s and cDC2s, from monocyte-derived macrophages. Here, we further refine DC/macrophages cell classification and report that classically defined cDC2s contain a discrete population of monocyte-derived migratory antigen-presenting cells with macrophages phenotype but functional DC features, including cross-presentation.
Author Info: (1) Nanyang Technological University, School of Biological Sciences, 60 Nanyang Drive, Singapore 637551, Singapore. (2) Nanyang Technological University, School of Biological Scien
Author Info: (1) Nanyang Technological University, School of Biological Sciences, 60 Nanyang Drive, Singapore 637551, Singapore. (2) Nanyang Technological University, School of Biological Sciences, 60 Nanyang Drive, Singapore 637551, Singapore. (3) Nanyang Technological University, School of Biological Sciences, 60 Nanyang Drive, Singapore 637551, Singapore. (4) Nanyang Technological University, School of Biological Sciences, 60 Nanyang Drive, Singapore 637551, Singapore. (5) Nanyang Technological University, School of Biological Sciences, 60 Nanyang Drive, Singapore 637551, Singapore. Electronic address: klaus@ntu.edu.sg. (6) Nanyang Technological University, School of Biological Sciences, 60 Nanyang Drive, Singapore 637551, Singapore. Electronic address: ruedl@ntu.edu.sg.
