(1) Li Z (2) Ju X (3) Silveira PA (4) Abadir E (5) Hsu WH (6) Hart DNJ (7) Clark GJ

Frontiers in immunology | Free PMC Article

CD83 is a member of the immunoglobulin (Ig) superfamily and is expressed in membrane bound or soluble forms. Membrane CD83 (mCD83) can be detected on a variety of activated immune cells, although it is most highly and stably expressed by mature dendritic cells (DC). mCD83 regulates maturation, activation and homeostasis. Soluble CD83 (sCD83), which is elevated in the serum of patients with autoimmune disease and some hematological malignancies is reported to have an immune suppressive function. While CD83 is emerging as a promising immune modulator with therapeutic potential, some important aspects such as its ligand/s, intracellular signaling pathways and modulators of its expression are unclear. In this review we discuss the recent biological findings and the potential clinical value of CD83 based therapeutics in various conditions including autoimmune disease, graft-vs.-host disease, transplantation and hematological malignancies.

Author Info: (1) Dendritic Cell Research, ANZAC Research Institute, Sydney, NSW, Australia. Sydney Medical School, The University of Sydney, Sydney, NSW, Australia. (2) Dendritic Cell Research,

Author Info: (1) Dendritic Cell Research, ANZAC Research Institute, Sydney, NSW, Australia. Sydney Medical School, The University of Sydney, Sydney, NSW, Australia. (2) Dendritic Cell Research, ANZAC Research Institute, Sydney, NSW, Australia. Sydney Medical School, The University of Sydney, Sydney, NSW, Australia. (3) Dendritic Cell Research, ANZAC Research Institute, Sydney, NSW, Australia. Sydney Medical School, The University of Sydney, Sydney, NSW, Australia. (4) Dendritic Cell Research, ANZAC Research Institute, Sydney, NSW, Australia. Sydney Medical School, The University of Sydney, Sydney, NSW, Australia. (5) Dendritic Cell Research, ANZAC Research Institute, Sydney, NSW, Australia. Sydney Medical School, The University of Sydney, Sydney, NSW, Australia. (6) Dendritic Cell Research, ANZAC Research Institute, Sydney, NSW, Australia. Sydney Medical School, The University of Sydney, Sydney, NSW, Australia. (7) Dendritic Cell Research, ANZAC Research Institute, Sydney, NSW, Australia. Sydney Medical School, The University of Sydney, Sydney, NSW, Australia.

Citation: Front Immunol 2019 10:1312 Epub06/07/2019

Link to PUBMED: http://www.ncbi.nlm.nih.gov/pubmed/31231400

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