In the Spotlight...

Large-scale transcript variants dictate neoepitopes for cancer immunotherapy

Ji et al. used full-length ribosome–nascent chain complex–bound mRNAseq (FL-RNCseq) and an AI-based prediction model (FIONA2) to profile neoepitope landscapes, including large-scale transcript variant...

Stem-like memory and precursors of exhausted T cells share a common progenitor defined by ID3 expression

Using single-cell RNA sequencing, Gago da Graça, Sheikh, and Newman et al. investigated developmental relationships between stem-like memory T cells and Tpex cells, and their roles in infection and c...

Trogocytosis of chimeric antigen receptors between T cells is regulated by their transmembrane domains

Barbera et al. showed that T cells reciprocally transferred CARs and TCRs via trogocytosis in vitro and in mouse models. T cell activation boosted trogocytosis. CAR transfer to T, B, and NK cells was ...

Oncolytic reprogramming of tumor microenvironment shapes CD4 T-cell memory via the IL6ra-Bcl6 axis for targeted control of glioblastoma

Grimes et al. interrogated an IL-12 oncolytic virus (M002) in glioblastoma in mice. CD4+ T cells were required for efficacy, and M002 significantly increased infiltration and polyfunctionality while s...

Previous Digests

Cholesterol supports cDC maturation, while AXL dampens in

February 5, 2025

The maturation of dendritic cells plays a critical role in initiating a cascade of immune responses, but exactly how cDCs mature in the absence of inflammation is not entirely understood. Investigating this process, Belabed and Park et al. found...

First glimpses of efficacy of personalized neoantigen vaccine plus checkpoint blockade in advanced cancers

January 29, 2025

Few patients with advanced cancer respond or have durable response to current immunotherapies. One of the challenges is that neoantigen-specific T cell responses only rarely spontaneously arise in many tumors. Therefore, therapies that trigger the induction of neoantigen-specific T...

Why anti-CTLA-4 promotes better memory responses than anti-PD-1

January 22, 2025

In the clinic, anti-CTLA-4 induces more durable responses than anti-PD-1. In recent research, Mok et al. investigated possible mechanisms underlying this durability by using a variety of mouse tumor and vaccine models. They found that anti-CTLA-4 induced stronger memory...

Watch ACIR in action

In November 2019, ACIR received the Visionary Award from the Cambridge Chamber of Commerce.

Watch the 3-minute video explaining ACIR's mission and goal:

In September 2020, ACIR was featured in the documentary The American Dream on Bloomberg TV.

Watch the 6-minute segment on the story behind your favorite digest here:

About ACIR

ACIR's mission is to fast-track cancer immunotherapy research by helping researchers stay on top of the new literature in this fast-moving and multifaceted field, fostering their creativity and productivity in bringing us ever closer to curing this deadly disease.

Ed Fritsch

Ed Fritsch

Ute Burkhardt

Ute Burkhardt

Lauren Hitchings

Lauren Hitchings

Gaelle Llambi

Gaelle Llambi

Maartje Wouters

Maartje Wouters

Alex Najibi

Alex Najibi

Katherine J. Turner

Katherine J. Turner

Stan Wolf

Stan Wolf

Paula Hochman

Paula Hochman

Shishir Pant

Shishir Pant

Nathan Suek

Nathan Suek

Morgan Janes

Morgan Janes

Current Sponsors

Close Modal

Small change for you. Big change for us!

This Thanksgiving season, show your support for cancer research by donating your change.

In less than a minute, link your credit card with our partner RoundUp App.

Every purchase you make with that card will be rounded up and the change will be donated to ACIR.

All transactions are securely made through Stripe.