In the Spotlight...
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Previous Digests
LNP mRNA delivery gets a metabolic boost from amino acid supplement
April 1, 2026
Notice: The article we intended to feature this week was briefly delayed in publication. We will share it with you as soon as the embargo is lifted. In the meantime, we encourage you to revisit last week's feature — it's well...
LNP mRNA delivery gets a metabolic boost from amino acid supplement
March 25, 2026
Lipid nanoparticles (LNPs) have allowed for the delivery of therapeutic mRNA for various therapeutic applications. However, in vivo delivery efficacy is often limited, and research is focused on optimization of LNP formulations. In recent work published in Science Translational...
The surprising effect of TOX in CD4+ T cells
March 18, 2026
In settings of chronic antigen stimulation, such as chronic infection and cancer, expression of the transcription factor TOX in CD8+ T cells has been associated with cell persistence and survival, but also with exhaustion, dysfunction, and poor prognosis. As...
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