Autophagy protects tumors from T cell–mediated cytotoxicity via inhibition of TNFα-induced apoptosis
T Cells Expressing NKG2D CAR with a DAP12 Signaling Domain Stimulate Lower Cytokine Production While Effective in Tumor Eradication
Quality of CD8+ T cell immunity evoked in lymph nodes is compartmentalized by route of antigen transport and functional in tumor context
The receptor DNGR-1 signals for phagosomal rupture to promote cross-presentation of dead-cell-associated antigens
For decades, adoptive cell transfer (ACT) of tumor-infiltrating lymphocytes (TILs) has achieved durable tumor regressions, although not consistently. However, the ACT infusion product, which is isolated from tumors and expanded ex vivo, comprises a heterogeneous population of T cells...
Although obesity is associated with cancer risk, the effects of obesity on the tumor microenvironment (TME) and antitumor immune responses are not fully known. Ringel and Drijvers et al. investigated how a high-fat diet shapes the TME using metabolic...
In the past, studies have shown that inhibition of MEK (MEKi) increases antitumor immunity and leads to the accumulation of activated CD8+ T cells in the TME. While this strategy is known to synergize with checkpoint inhibitors and adoptive...
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