In the Spotlight...
A viral-based individualized neoantigen vaccine as adjuvant treatment in resected head and neck squamous cell carcinoma: a randomized Phase I trial
Genome-scale perturb-seq in primary human CD4+ T cells maps context-specific regulators of T cell programs and human immune traits
Engineered human iPSC-derived dendritic cells dressed with tumor MHC complexes as a cancer vaccine
Scalable generation of hematopoietic stem cell-engineered off-the-shelf mono-specific cytotoxic T cells targeting solid tumors
Previous Digests
Fun in the sun: how melanocytes avoid immune clearance, despite UV damage
August 19, 2026
Melanocytes in human skin are regularly exposed to ultraviolet radiation (UVR) from the sun, and can accumulate substantial DNA damage without being eliminated by the immune system. In recent work published in Immunity, Lo et al. investigated how these...
Activated DCs go beyond priming to sustain tumoral T cell responses
August 12, 2026
A subset of cDCs within tumors expresses T cell-stimulating and immune-regulatory molecules. The exact role of these activated DCs (actDCs) in antitumor immunity remains largely unknown, and given their scarcity, they are a challenge to study. Koufaki et al...
Helpers don’t clock out: CD4s essential for both priming and effector phases of ICB
August 5, 2026
While CD4+ T cells are crucial for CD8+ T cell priming in ICB-induced antitumor responses, their helper role at the effector phase remains largely unknown. Ameh et al. used murine MHC-II- sarcoma models to study CD4+ T cell help...
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