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Tregs versus Tconv: a battle over metastasis in PDA

Pancreatic ductal adenocarcinoma (PDA) is an aggressive and difficult-to-treat-tumor type with complex immune dynamics and multiple immune evasion mechanisms at different stages of disease. In work recently published in Science Immunology, Schmiechen...

Addressing Biases in Analysis of Time of Infusion: NCI/SWOG Trial S1404 Among Participants With High-Risk Resectable Melanoma Who Received Adjuvant Anti-PD-1 Therapy

In an analysis of a multi-center trial involving 628 patients with high-risk melanoma receiving adjuvant pembrolizumab, Othus et al. identified optimal time cut-points for the first infusion of 1:18 p...

FLT3L-secreting cDC1 in situ vaccination enhances antitumor immunity and synergizes with PD-1 blockade in murine non-small cell lung cancer

Abascal et al. engineered FLT3L-secreting mouse cDC1s that retained APC and phagocytic ability in vitro. In situ vaccination (ISV) with the cDC1s inhibited s.c. tumor growth in multiple syngeneic muri...

B cell-derived type I interferon sustains T cell functionality upon strong TCR stimulation during chronic infection

Graça et al. show that B cells are essential for CD8+ T cell effector response during chronic, but not acute, LCMV infection. In chronic infection, splenic B cells sense viruses via TLR7/8-STING pathw...

IL-2 mutein promotes antigen-specific transplant acceptance in mice through expansion of ST2(+) regulatory T cells

Focused on improving transplantation tolerance, Ganchiku et al. evaluated a long-lived, high-affinity receptor binding IL-2 mutein (mIL-2) in multiple solid organ transplantation models. mIL-2 therapy...

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Previous Digests

Exhausted, yet effective: Eomes drives Th-mediated antitumor responses

July 1, 2026

While accumulating evidence suggests an important role for CD4+ T cells in antitumor immunity, the specific subpopulations responsible remain to be defined. Agesta, Ferrand, et al. investigated the function of the transcription factor Eomes in CD4+ T cell antitumor...

Neutrophils not so neutral in tumors after all

June 24, 2026

Neutrophils in tumors are known to play both pro- and anti-inflammatory roles, but how they affect responses to immunotherapy is incompletely understood. In work recently published in Immunity, Pei et al. evaluated neutrophils in the context of several cancer...

taNKs on the frontline: CD39+ NK cells in the antitumor response

June 17, 2026

NK cell antitumor therapies are under development, but the functional states of tumoral NK cells remain poorly understood, limiting progress. Serger et al. profiled NK cells from non-small cell lung cancer (NSCLC) samples, identifying targetable subsets for immunotherapy. Their...

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