In the Spotlight...

Spermidine activates mitochondrial trifunctional protein and improves antitumor immunity in mice

Given an association between decreased serum spermidine (SPD) levels and age-related dysfunction, including immune dysfunction, Al-Habsi, Chamoto, Matsumoto, and Nomura et al. explored the impact of S...

Specific targeting of glioblastoma with an oncolytic virus expressing a cetuximab-CCL5 fusion protein via innate and adaptive immunity

To improve oncolytic viral therapy for glioblastoma (GBM) and other solid tumors, Tian and Xu et al. constructed OV-Cmab-CCL5, an HSV type 1-derived oncolytic virus secreting a heterodimeric Fc-based ...

Non-viral precision T cell receptor replacement for personalized cell therapy

Neoantigen-specific TCRs (neoTCR) were identified from patient CD8+ T cells and selected following insertion into healthy donor T cells; up to three neoTCRs were engineered into patient T cells using ...

Pooled screening of CAR T cells identifies diverse immune signaling domains for next-generation immunotherapies

Using pooled screens, Goodman and Azimi et al. assessed the impact of 40 distinct costimulatory domains on the function, persistence, and phenotype of CD19-directed CAR T cells in vitro. The BAFF-R, T...

Previous Digests

SITC Annual Meeting 2022

November 23, 2022

This week’s extensive special feature covers select talks from the 37th Annual Meeting of the Society for Immunotherapy of Cancer (SITC) in Boston, MA and virtually. We are proud to recognize Takeda for sponsorship of our coverage for this...

Targeting the sialoglycan-Siglec axis for cancer immunotherapy

November 16, 2022

In cancer, upregulation of sialic acid-containing glycans (hypersialylation) is a feature that has been shown to drive disease progression and immune escape through engagement with Siglec receptors and inhibition of tumor-infiltrating immune cells. In previous work, Stanczak et al...

Not all routes lead to Rome: administration route affects vaccine responses

November 9, 2022

Since cytolytic T cells are critical to cancer immunotherapy, therapeutic cancer vaccines, which can induce such T cells, can be an important component of immunotherapy. However, current vaccine approaches to improve the magnitude of the immune response have traditionally...

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About ACIR

ACIR's mission is to fast-track cancer immunotherapy research by helping researchers stay on top of the new literature in this fast-moving and multifaceted field, fostering their creativity and productivity in bringing us ever closer to curing this deadly disease.

Ed Fritsch

Ed Fritsch

Ute Burkhardt

Ute Burkhardt

Lauren Hitchings

Lauren Hitchings

Gaelle Lespinasse-Llambi

Gaelle Lespinasse-Llambi

Maartje Wouters

Maartje Wouters

Alex Najibi

Alex Najibi

Katherine J. Turner

Katherine J. Turner

Stan Wolf

Stan Wolf

Samuel (Sandy) Goldman

Samuel (Sandy) Goldman

Paula Hochman

Paula Hochman

Shishir Pant

Shishir Pant

Elaine Yee Lin Chung

Elaine Yee Lin Chung

Nathan Suek

Nathan Suek

Margot O'Toole

Margot O'Toole

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