In the Spotlight...

An activation to memory differentiation trajectory of tumor-infiltrating lymphocytes informs metastatic melanoma outcomes

Jaiswal et al. applied a systems biology approach to multiple single-cell and bulk RNAseq datasets to examine CD8+ TIL differentiation status, kinetic trajectories, and relatedness to patient survival...

LAG-3xPD-L1 bispecific antibody potentiates antitumor responses of T cells through dendritic cell activation

Sung and Ko et al. developed a bispecific antibody, ABL501, that co-targets PD-L1 and LAG3. In vitro, ABL501 enhanced the proliferation, activation, and effector functions of CD4+ and CD8+ T cells thr...

DNA damage promotes HLA class I presentation by stimulating a pioneer round of translation-associated antigen production

Uchihara et al. showed that DNA damage-induced upregulation of HLA-I (di-HLA) cell surface presentation required antigen generation dependent on transcription and splicing, but not on IFN, mutational ...

The immune checkpoint B7x expands tumor-infiltrating Tregs and promotes resistance to anti-CTLA-4 therapy

John et al. demonstrated that ectopic expression of B7-family immune checkpoint B7x regulated the Akt–Foxo1 pathway to enhance Foxp3 expression in conventional CD4+ T cells to promote their immunosupp...

Previous Digests

CIMT Annual Meeting 2022

May 18, 2022

Last week, the ACIR team attended the CIMT Annual Meeting 2022 in Mainz, Germany. This week’s extensive special feature covers select talks from the conference. We have organized the content by topics below. Personalized cancer immunotherapyAlena Gros VidalHajer Fritah...

Hang on there! T cells bringing IL-12 are more tumor-reactive

May 11, 2022

IL-12 is of great interest for immunotherapy for its broad immune-activating effects. However, systemic treatment induces severe toxicities, limiting its application. Approaches to safely deliver cytokines to the tumor microenvironment are therefore warranted. Jones and Nardozzi et al. investigated a...

Hormone-driven immune exhaustion fuels sex bias in cancer

May 4, 2022

Sex bias in the development, aggressiveness, and mortality of cancer is a well documented phenomenon that cannot be fully explained by behavioral, physical, or genetic differences. Looking into potential immunological mechanisms as to how biological sex, as defined by...

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About ACIR

ACIR's mission is to fast-track cancer immunotherapy research by helping researchers stay on top of the new literature in this fast-moving and multifaceted field, fostering their creativity and productivity in bringing us ever closer to curing this deadly disease.

Ed Fritsch

Ed Fritsch

Ute Burkhardt

Ute Burkhardt

Lauren Hitchings

Lauren Hitchings

Gaelle Lespinasse-Llambi

Gaelle Lespinasse-Llambi

Maartje Wouters

Maartje Wouters

Alex Najibi

Alex Najibi

Katherine J. Turner

Katherine J. Turner

Stan Wolf

Stan Wolf

Samuel (Sandy) Goldman

Samuel (Sandy) Goldman

Paula Hochman

Paula Hochman

Shishir Pant

Shishir Pant

Elaine Yee Lin Chung

Elaine Yee Lin Chung

Nathan Suek

Nathan Suek

Margot O'Toole

Margot O'Toole

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