Pathological response and survival with neoadjuvant therapy in melanoma: a pooled analysis from the International Neoadjuvant Melanoma Consortium (INMC)
Survival and biomarker analyses from the OpACIN-neo and OpACIN neoadjuvant immunotherapy trials in stage III melanoma
CTLA-4 blockade drives loss of T(reg) stability in glycolysis-low tumours
Therapeutically increasing MHC-I expression potentiates immune checkpoint blockade
Given that it is consistently expressed by tumor cells and contributes to malignant transformation, the HPV E7 antigen is an interesting target for immunotherapy in HPV-associated carcinomas. Nagarsheth et al. previously developed a high avidity TCR that recognizes the...
A growing understanding of the gut microbiome has uncovered critical roles in regulating host immunity, metabolic health, and progression of diseases such as cancer. Recently, the composition of the microbiome has been linked to anti-PD-1 therapeutic response. Fecal microbiota...
Even though TILs predict survival and response to immune checkpoint inhibition in non-small cell lung cancer (NSCLC), the origins of these cells remain largely unknown. Gueguen and Metoikidou et al. performed single-cell RNAseq (scRNAseq) and TCRseq (scTCRseq) on tumors...
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