PARP14 inhibition restores PD-1 immune checkpoint inhibitor response following IFNγ-driven acquired resistance in preclinical cancer models
Phenotypic signatures of circulating neoantigen-reactive CD8+ T cells in patients with metastatic cancers
One of the reasons immune checkpoint blockade (ICB) may fail in solid tumors like pancreatic ductal adenocarcinoma (PDA) is a lack of T cell infiltration and extensive myeloid inflammation in the tumor microenvironment (TME). Wattenberg et al. aimed to...
Dendritic cell (DC)-based cancer vaccines have great potential but are currently lacking in efficacy. Adamik et al. investigated the transcriptomic and immune-metabolic characteristics of DCs from patients with melanoma to better understand how cancer may impact antigen presentation function...
This week’s extensive special feature covers select talks from the SITC - 38th Annual Meeting 2023 in San Diego, CA. We have organized the content by topics below. Keynote AddressSusan Kaech Microbiome and metabolismSusan BullmanYoungseok ChoLydia Lynch Cell-based immunotherapiesFelix...
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Professor of Medicine, Harvard Medical School; Director, MGH Center for Cancer Immunology; Institute Member, Broad Institute of Harvard and MIT
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