In the Spotlight...
Loss of the autoimmune risk gene TREX1 reveals a convergence of mechanisms promoting immune tolerance loss and antitumor immunity
Tumors hijack immune-privileging regulons via distinct cell types to confer T cell desertion and immunotherapy resistance across various cancers
Polymer-mRNA complexes for monocyte-trafficked, lymph node-targeted cancer vaccination
Ferroptosis-armed dendritic cell vaccines for glioma immunotherapy
Previous Digests
Intratumoral anti-CTLA-4 could reduce severe AEs: Results from a phase 1b clinical trial
May 13, 2026
The combination of nivolumab (anti-PD-1) and ipilimumab (anti-CTLA-4), both administered intravenously, has been approved for the treatment of cancer in a variety of settings since 2015, but its use is frequently hindered by severe adverse events, more often associated...
NK cells unleashed by Treg ablation
May 6, 2026
When tumors lose expression of MHC-I under the selective pressure of CD8+ T cells, NK cells may step in and take on a more prominent antitumor role, but often this is still insufficient to control tumors. Investigating potential mechanisms...
No cDC1, no worries: cDC2 and cross-dressing prime T cells in response to mRNA-LNP vaccination
April 29, 2026
cDC1s play essential roles in CD8+ T cell priming in response to protein- and DNA-based vaccination. However, whether mRNA vaccines function via a similar mechanism remains unknown. In a recent Nature publication, Jo et al. uncovered the mechanisms of...
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ACIR's mission is to fast-track cancer immunotherapy research by helping researchers stay on top of the new literature in this fast-moving and multifaceted field, fostering their creativity and productivity in bringing us ever closer to curing this deadly disease.
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