Author Info: (1) Department of Immunology & Theranostics, Arthur Riggs Diabetes & Metabolism Research Institute, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA. (2) Depar

Author Info: (1) Department of Immunology & Theranostics, Arthur Riggs Diabetes & Metabolism Research Institute, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA. (2) Department of Immunology & Theranostics, Arthur Riggs Diabetes & Metabolism Research Institute, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA. (3) Department of Botany & Plant Sciences, University of California, Riverside, CA 92527, USA. (4) Department of Immunology & Theranostics, Arthur Riggs Diabetes & Metabolism Research Institute, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA. (5) Department of System Biology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA. (6) Department of Immunology & Theranostics, Arthur Riggs Diabetes & Metabolism Research Institute, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA. (7) Translational Bioinformatics, Department of Computational Quantitative Medicine, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA. (8) Integrated Genomics Core, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA. (9) Gehr Family Center for Leukemia Research, Department of Hematological Malignancies Translational Science, Hematologic Malignancies and Stem Cell Transplantation Institute, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA. (10) Department of System Biology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA. (11) Department of Botany & Plant Sciences, University of California, Riverside, CA 92527, USA. (12) Gehr Family Center for Leukemia Research, Department of Hematological Malignancies Translational Science, Hematologic Malignancies and Stem Cell Transplantation Institute, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA. (13) Department of Immunology & Theranostics, Arthur Riggs Diabetes & Metabolism Research Institute, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.

Author Info: (1) Department of Medicine and Moores Cancer Center, School of Medicine, University of California San Diego, San Diego, CA, USA. (2) Department of Medicine and Moores Cancer Center

Author Info: (1) Department of Medicine and Moores Cancer Center, School of Medicine, University of California San Diego, San Diego, CA, USA. (2) Department of Medicine and Moores Cancer Center, School of Medicine, University of California San Diego, San Diego, CA, USA. (3) Department of Computer Science and Engineering, University of California San Diego, San Diego, CA, USA. (4) Department of Medicine and Moores Cancer Center, School of Medicine, University of California San Diego, San Diego, CA, USA. (5) Department of Medicine and Moores Cancer Center, School of Medicine, University of California San Diego, San Diego, CA, USA. (6) Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA. (7) Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA. (8) Lunit Incorporated, Seoul, South Korea. (9) Lunit Incorporated, Seoul, South Korea. (10) Lunit Incorporated, Seoul, South Korea. (11) Department of Medicine and Moores Cancer Center, School of Medicine, University of California San Diego, San Diego, CA, USA. (12) Department of Medicine and Moores Cancer Center, School of Medicine, University of California San Diego, San Diego, CA, USA. Department of Computer Science and Engineering, University of California San Diego, San Diego, CA, USA. Department of Bioengineering, University of California San Diego, San Diego, CA, USA.

Author Info: (1) Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA. Department of Biological Engineering, Massachusett

Author Info: (1) Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA. Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA. Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02139, USA. Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA. (2) Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA. (3) Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02139, USA. (4) Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02139, USA. Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. (5) Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02139, USA. (6) Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02139, USA. (7) Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02139, USA. (8) Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02139, USA. Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. (9) Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02139, USA. (10) Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02139, USA. (11) Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02139, USA. (12) Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA. Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA. Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA. Department of Physics, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA. Institute for Medical Engineering and Science, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA. (13) Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02139, USA. Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA. Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.

Author Info: (1) Holy Cross and University of Miami, Fort Lauderdale, FL, USA. (2) Division of Surgical Oncology, Department of Surgery, University of California Los Angeles, Los Angeles, CA, U

Author Info: (1) Holy Cross and University of Miami, Fort Lauderdale, FL, USA. (2) Division of Surgical Oncology, Department of Surgery, University of California Los Angeles, Los Angeles, CA, USA. (3) Division of Hematology and Oncology, Department of Medicine, University of California Los Angeles, Los Angeles, CA, USA. (4) Division of Surgical Oncology, Department of Surgery, University of California Los Angeles, Los Angeles, CA, USA. (5) Division of Hematology and Oncology, Department of Medicine, University of California Los Angeles, Los Angeles, CA, USA. (6) Division of Surgical Oncology, Department of Surgery, University of California Los Angeles, Los Angeles, CA, USA. nskapoor@mednet.ucla.edu.

Author Info: (1) School of Pharmaceutical Sciences & State Key Laboratory of Functions and Applications of Medicinal Plants & Microbiology and Biochemical Pharmaceutical Engineering Research Ce

Author Info: (1) School of Pharmaceutical Sciences & State Key Laboratory of Functions and Applications of Medicinal Plants & Microbiology and Biochemical Pharmaceutical Engineering Research Center of Guizhou Provincial Department of Education, Guizhou Medical University, Guiyang, 550025, China. Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing, 100850, China. (2) Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing, 100850, China. (3) Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing, 100850, China. (4) Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing, 100850, China. (5) School of Pharmaceutical Sciences & State Key Laboratory of Functions and Applications of Medicinal Plants & Microbiology and Biochemical Pharmaceutical Engineering Research Center of Guizhou Provincial Department of Education, Guizhou Medical University, Guiyang, 550025, China. (6) School of Pharmaceutical Sciences & State Key Laboratory of Functions and Applications of Medicinal Plants & Microbiology and Biochemical Pharmaceutical Engineering Research Center of Guizhou Provincial Department of Education, Guizhou Medical University, Guiyang, 550025, China. Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing, 100850, China. (7) Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing, 100850, China. (8) Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing, 100850, China. (9) Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing, 100850, China. (10) Advanced Research Institute of Multidisciplinary Science, School of Life Science, School of Medical Technology (Institute of Engineering Medicine), Key Laboratory of Molecular Medicine and Biotherapy, Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering Beijing Institute of Technology, Beijing, 100081, China. (11) School of Pharmaceutical Sciences & State Key Laboratory of Functions and Applications of Medicinal Plants & Microbiology and Biochemical Pharmaceutical Engineering Research Center of Guizhou Provincial Department of Education, Guizhou Medical University, Guiyang, 550025, China. (12) Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing, 100850, China.

Author Info: (1) Department of Hematology/Oncology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, 530021, China. State Key Laboratory of Targeting Oncology, Guangxi Medical Univ

Author Info: (1) Department of Hematology/Oncology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, 530021, China. State Key Laboratory of Targeting Oncology, Guangxi Medical University, Nanning, Guangxi, 530021, China. (2) Department of Hematology/Oncology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, 530021, China. Department of Thyroid and Breast Surgery, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Guangxi, Nanning, 530022, China. (3) Department of Pharmacy Foresea Life Insurance Guangxi Hospital, Nanning, Guangxi, 530200, China. (4) Department of Hematology/Oncology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, 530021, China. (5) Department of Hematology/Oncology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, 530021, China. (6) Department of Hematology/Oncology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, 530021, China. (7) Department of Hematology/Oncology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, 530021, China. (8) Department of Hematology/Oncology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, 530021, China. (9) Department of Hematology/Oncology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, 530021, China. (10) Department of Hematology/Oncology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, 530021, China. (11) Department of Hematology/Oncology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, 530021, China. (12) College of Oncology, Guangxi Medical University,Nanning, Guangxi, 530021, China. (13) Department of Hematology/Oncology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, 530021, China. (14) Department of Hematology/Oncology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, 530021, China.

Author Info: (1) School of Pharmacy & Medical Sciences, Gold Coast campus, Griffith University, Brisbane, QLD-4222, Australia. Menzies Health Institute Queensland (MHIQ), Gold Coast Campus, Gri

Author Info: (1) School of Pharmacy & Medical Sciences, Gold Coast campus, Griffith University, Brisbane, QLD-4222, Australia. Menzies Health Institute Queensland (MHIQ), Gold Coast Campus, Griffith University, Brisbane, QLD-4215, Australia. (2) School of Pharmacy & Medical Sciences, Gold Coast campus, Griffith University, Brisbane, QLD-4222, Australia. Menzies Health Institute Queensland (MHIQ), Gold Coast Campus, Griffith University, Brisbane, QLD-4215, Australia. (3) School of Allied Health, Australian Catholic University, Brisbane, QLD-4014, Australia. (4) School of Pharmacy & Medical Sciences, Gold Coast campus, Griffith University, Brisbane, QLD-4222, Australia. Menzies Health Institute Queensland (MHIQ), Gold Coast Campus, Griffith University, Brisbane, QLD-4215, Australia.

Author Info: (1) Department of Biochemistry, University of Washington, Seattle, WA, USA. Institute for Protein Design, University of Washington, Seattle, WA, USA. Department of Bioengineering,

Author Info: (1) Department of Biochemistry, University of Washington, Seattle, WA, USA. Institute for Protein Design, University of Washington, Seattle, WA, USA. Department of Bioengineering, University of Washington, Seattle, WA, USA. (2) Department of Biochemistry, University of Washington, Seattle, WA, USA. Institute for Protein Design, University of Washington, Seattle, WA, USA. (3) Department of Chemistry, Stanford University, Stanford, CA, USA. (4) Department of Biochemistry, University of Washington, Seattle, WA, USA. Institute for Protein Design, University of Washington, Seattle, WA, USA. Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA. (5) Department of Biochemistry, University of Washington, Seattle, WA, USA. Institute for Protein Design, University of Washington, Seattle, WA, USA. (6) Instituto de Medicina Molecular Jo‹o Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal. (7) Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX, USA. (8) Department of Biochemistry, University of Washington, Seattle, WA, USA. Institute for Protein Design, University of Washington, Seattle, WA, USA. (9) Department of Biochemistry, University of Washington, Seattle, WA, USA. Institute for Protein Design, University of Washington, Seattle, WA, USA. (10) Institute for Protein Design, University of Washington, Seattle, WA, USA. (11) Department of Biochemistry, University of Washington, Seattle, WA, USA. Institute for Protein Design, University of Washington, Seattle, WA, USA. Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA. (12) Institute for Protein Design, University of Washington, Seattle, WA, USA. (13) Department of Biochemistry, University of Washington, Seattle, WA, USA. Institute for Protein Design, University of Washington, Seattle, WA, USA. (14) Institute for Protein Design, University of Washington, Seattle, WA, USA. (15) Institute for Protein Design, University of Washington, Seattle, WA, USA. (16) Institute for Protein Design, University of Washington, Seattle, WA, USA. (17) Department of Biochemistry, University of Washington, Seattle, WA, USA. Institute for Protein Design, University of Washington, Seattle, WA, USA. (18) Novo Nordisk, MŒl¿v, Denmark. (19) Novo Nordisk, MŒl¿v, Denmark. (20) Novo Nordisk, MŒl¿v, Denmark. (21) Novo Nordisk, MŒl¿v, Denmark. (22) Novo Nordisk, MŒl¿v, Denmark. (23) Departments of Biomedical Engineering and Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA. Medical Scientist Training Program, Johns Hopkins University School of Medicine, Baltimore, MD, USA. (24) Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA. (25) Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA. (26) Department of Biochemistry, University of Washington, Seattle, WA, USA. Institute for Protein Design, University of Washington, Seattle, WA, USA. (27) Department of Biochemistry, University of Washington, Seattle, WA, USA. Institute for Protein Design, University of Washington, Seattle, WA, USA. (28) Institute for Protein Design, University of Washington, Seattle, WA, USA. (29) Institute for Protein Design, University of Washington, Seattle, WA, USA. (30) Department of Biochemistry, University of Washington, Seattle, WA, USA. Institute for Protein Design, University of Washington, Seattle, WA, USA. (31) Department of Biochemistry, University of Washington, Seattle, WA, USA. Institute for Protein Design, University of Washington, Seattle, WA, USA. (32) Hubrecht Institute, Utrecht, The Netherlands. (33) Institute for Protein Design, University of Washington, Seattle, WA, USA. (34) Harvard Medical School, Harvard University, Boston, MA, USA. (35) Division of Biology and Bioengineering, California Institute of Technology, Pasadena, CA, USA. (36) School of Life Sciences, Westlake University, Hangzhou, China. (37) Institute for Protein Design, University of Washington, Seattle, WA, USA. (38) Institute for Protein Design, University of Washington, Seattle, WA, USA. (39) Novo Nordisk, MŒl¿v, Denmark. (40) Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA. (41) Novo Nordisk, MŒl¿v, Denmark. (42) Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX, USA. (43) Instituto de Medicina Molecular Jo‹o Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal. Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK. (44) Department of Chemistry, Stanford University, Stanford, CA, USA. Howard Hughes Medical Institute, Stanford, CA, USA. Sarafan ChEM-H, Stanford University, Stanford, CA, USA. (45) Department of Biochemistry, University of Washington, Seattle, WA, USA. dabaker@uw.edu. Institute for Protein Design, University of Washington, Seattle, WA, USA. dabaker@uw.edu. Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA. dabaker@uw.edu.

Author Info: (1) Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan. Department of Gastroenterological Surgery, Graduate School of Medic

Author Info: (1) Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan. Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan. (2) Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan. Department of Aging and Geriatric Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan. (3) Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan. Center for Metabolic Regulation of Healthy Aging (CMHA), Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan. (4) Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan. Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan. (5) Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan. (6) Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan. (7) Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan. (8) Center for Metabolic Regulation of Healthy Aging (CMHA), Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan. Department of Molecular and Medical Pharmacology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan. (9) Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan. Center for Metabolic Regulation of Healthy Aging (CMHA), Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan. (10) Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan. Department of Aging and Geriatric Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan. Center for Metabolic Regulation of Healthy Aging (CMHA), Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.

Author Info: (1) Department of Radiation Oncology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, 130033, China. (2) Key Laboratory of Polymer Ecomaterials, Changchun Institu

Author Info: (1) Department of Radiation Oncology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, 130033, China. (2) Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022, China. (3) Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022, China. (4) Department of Radiation Oncology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, 130033, China. (5) Department of Radiation Oncology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, 130033, China. (6) Key Laboratory of UV-Emitting Materials and Technology, Northeast Normal University, Ministry of Education, Changchun, Jilin, 130024, China. (7) Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022, China. (8) Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022, China.