Author Info: 1-IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy. 2- Institute of Genetic and Biomedical Research, UoS Milan, National Research Council, Rozzano, Milan, Italy. 3- Departm

Author Info: 1-IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy. 2- Institute of Genetic and Biomedical Research, UoS Milan, National Research Council, Rozzano, Milan, Italy. 3- Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy. 4- Discovery Biology, Bristol Myers Squibb Company, Redwood City, California, CA, USA. 5- These authors contributed equally: Julian Swatler, Simone Puccio. e-mail: julian.swatler@humanitasresearch.it; enrico.lugli@humanitasresearch.it

Author Info: 1. Department of Medical Oncology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan 2. Department of Respiratory Medicine, Faculty of Medici

Author Info: 1. Department of Medical Oncology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan 2. Department of Respiratory Medicine, Faculty of Medicine, Hokkaido University, Sapporo, Japan 3. Department of Medical Oncology, Shinshu Cancer Center, Shinshu University Hospital, Matsumoto, Japan 4. Division of Molecular Psychoimmunology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan 5. Department of Medical Oncology, Hokkaido University Hospital, Sapporo, Japan 6. Division of Clinical Cancer Genomics, Hokkaido University Hospital, Sapporo, Japan 7. Quantum immunology Team, Institute for Quantum Life science, National Institute for Quantum and Radiological Science and Technology (QST), Chiba, Japan 8. Division of Molecular Neuroimmunology, Department of Homeostatic Regulation, National Institute for Physiological Sciences, National Institutes of Natural Sciences, Aichi, Japan 9. Institute for Vaccine Research and Development, Hokkaido University, Sapporo 001-0021, Japan

Author Info: (1) Pfizer, Inc., Bothell, WA 98021, USA. (2) Pfizer, Inc., Bothell, WA 98021, USA. (3) Seagen, Inc., Bothell, WA 98021, USA. (4) Pfizer, Inc., Bothell, WA 98021, USA. (5) Pfizer,

Author Info: (1) Pfizer, Inc., Bothell, WA 98021, USA. (2) Pfizer, Inc., Bothell, WA 98021, USA. (3) Seagen, Inc., Bothell, WA 98021, USA. (4) Pfizer, Inc., Bothell, WA 98021, USA. (5) Pfizer, Inc., Bothell, WA 98021, USA. (6) Pfizer, Inc., Bothell, WA 98021, USA. (7) Pfizer, Inc., Bothell, WA 98021, USA. (8) Seagen, Inc., Bothell, WA 98021, USA. (9) Pfizer, Inc., Bothell, WA 98021, USA. (10) Pfizer, Inc., Bothell, WA 98021, USA. (11) Pfizer, Inc., Bothell, WA 98021, USA. (12) Seagen, Inc., Bothell, WA 98021, USA. (13) Seagen, Inc., Bothell, WA 98021, USA. (14) Pfizer, Inc., Bothell, WA 98021, USA. (15) Pfizer, Inc., Bothell, WA 98021, USA. (16) Seagen, Inc., Bothell, WA 98021, USA. (17) Seagen, Inc., Bothell, WA 98021, USA. (18) Astellas Pharma Inc., Tsukuba, Ibaraki, Japan. (19) Astellas Research Institute of America LLC, Northbrook, IL 60062, USA. (20) Pfizer, Inc., Bothell, WA 98021, USA. (21) Pfizer, Inc., Bothell, WA 98021, USA. (22) Pfizer, Inc., Bothell, WA 98021, USA. Electronic address: sharsti.sandall@pfizer.com.

Author Info: (1) Erasmus MC Rotterdam Netherlands. ROR: https://ror.org/018906e22 (2) Erasmus MC Cancer Institute Rotterdam, South-Holland Netherlands. ROR: https://ror.org/03r4m3349 (3) Erasmu

Author Info: (1) Erasmus MC Rotterdam Netherlands. ROR: https://ror.org/018906e22 (2) Erasmus MC Cancer Institute Rotterdam, South-Holland Netherlands. ROR: https://ror.org/03r4m3349 (3) Erasmus MC Netherlands. ROR: https://ror.org/018906e22 (4) Cancer Research UK Scotland Institute United Kingdom. ROR: https://ror.org/03pv69j64 (5) Erasmus MC Cancer Institute Rotterdam Netherlands. ROR: https://ror.org/03r4m3349 (6) Erasmus MC Cancer Institute Netherlands. ROR: https://ror.org/03r4m3349 (7) Erasmus MC Rotterdam Rotterdam Netherlands. (8) Erasmus MC Cancer Institute Netherlands. ROR: https://ror.org/03r4m3349 (9) Erasmus MC Rotterdam Rotterdam Netherlands. (10) Erasmus MC Cancer Institute Rotterdam Netherlands. ROR: https://ror.org/03r4m3349 (11) Erasmus MC Cancer Institute Rotterdam Netherlands. ROR: https://ror.org/03r4m3349 (12) Erasmus MC Rotterdam Netherlands. ROR: https://ror.org/018906e22 (13) University of Warsaw Poland. ROR: https://ror.org/039bjqg32 (14) Erasmus MC Rotterdam Netherlands. ROR: https://ror.org/018906e22 (15) Erasmus MC - Sophia Children's Hospital Rotterdam, South Holland Netherlands. ROR: https://ror.org/047afsm11 (16) Erasmus MC Rotterdam Netherlands. ROR: https://ror.org/018906e22 (17) Erasmus MC Rotterdam Rotterdam Netherlands. (18) Erasmus MC Cancer Institute Rotterdam Netherlands. ROR: https://ror.org/03r4m3349 (19) Erasmus MC Cancer Institute Rotterdam Netherlands. ROR: https://ror.org/03r4m3349

Author Info: (1) Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States. MD Anderson UTHealth Graduate School of Biomedical Sciences, The Univer

Author Info: (1) Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States. MD Anderson UTHealth Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, United States. (2) Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States. (3) Department of Bioinformatics and Computational Biology, Division of Discovery Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, United States. (4) Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States. (5) Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States. (6) Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States. (7) Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States. MD Anderson UTHealth Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, United States. (8) Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States. (9) Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States. (10) Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States. MD Anderson UTHealth Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, United States. (11) Department of Bioinformatics and Computational Biology, Division of Discovery Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, United States. (12) Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States. MD Anderson UTHealth Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, United States. (13) Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States. MD Anderson UTHealth Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.

Author Info: (1) Faculty of Biology, Technion-Israel Institute of Technology, Haifa, Israel. (2) Translational Skin Cancer Research, German Cancer Consortium (DKTK), Partner Site Essen, Medical

Author Info: (1) Faculty of Biology, Technion-Israel Institute of Technology, Haifa, Israel. (2) Translational Skin Cancer Research, German Cancer Consortium (DKTK), Partner Site Essen, Medical Faculty, University of Duisburg-Essen, Essen, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany. (3) Translational Skin Cancer Research, German Cancer Consortium (DKTK), Partner Site Essen, Medical Faculty, University of Duisburg-Essen, Essen, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Dermatology, University Hospital Essen, Essen, Germany. (4) German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Dermatology, University Hospital Essen, Essen, Germany. (5) Translational Skin Cancer Research, German Cancer Consortium (DKTK), Partner Site Essen, Medical Faculty, University of Duisburg-Essen, Essen, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Dermatology, University Hospital Essen, Essen, Germany. Electronic address: j.becker@dkfz-heidelberg.de. (6) Faculty of Biology, Technion-Israel Institute of Technology, Haifa, Israel; The Taub Faculty of Computer Science, Technion-Israel Institute of Technology, Haifa, Israel. Electronic address: dviraran@technion.ac.il.

Author Info: (1) Department of Medicine, University of California San Francisco, San Francisco, CA, USA. qi.liu3@ucsf.edu. Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA

Author Info: (1) Department of Medicine, University of California San Francisco, San Francisco, CA, USA. qi.liu3@ucsf.edu. Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA. qi.liu3@ucsf.edu. (2) Department of Medicine, University of California San Francisco, San Francisco, CA, USA. Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA. (3) Department of Medicine, University of California San Francisco, San Francisco, CA, USA. Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA. (4) Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA. (5) Department of Medicine, University of California San Francisco, San Francisco, CA, USA. Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA. (6) Department of Medicine, University of California San Francisco, San Francisco, CA, USA. Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA. (7) Department of Medicine, University of California San Francisco, San Francisco, CA, USA. Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA. (8) Department of Medicine, University of California San Francisco, San Francisco, CA, USA. Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA. UCSF CoLabs, University of California San Francisco, San Francisco, CA, USA. Department of Surgery, University of California San Francisco, San Francisco, CA, USA. Diabetes Center, University of California San Francisco, San Francisco, CA, USA. (9) Department of Medicine, University of California San Francisco, San Francisco, CA, USA. Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA. (10) Department of Medicine, University of California San Francisco, San Francisco, CA, USA. Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA. (11) Department of Medicine, University of California San Francisco, San Francisco, CA, USA. Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA. (12) Department of Microbiology and Immunology and Howard Hughes Medical Institute, University of California San Francisco, San Francisco, CA, USA. (13) Department of Medicine, University of California San Francisco, San Francisco, CA, USA. Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA. (14) Department of Medicine, University of California San Francisco, San Francisco, CA, USA. Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA. (15) Department of Microbiology and Immunology and Howard Hughes Medical Institute, University of California San Francisco, San Francisco, CA, USA. Division of Pediatric Rheumatology, Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA. (16) Department of Medicine, University of California San Francisco, San Francisco, CA, USA. (17) Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA. (18) Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA. Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA. (19) Department of Medicine, University of California San Francisco, San Francisco, CA, USA. Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA. (20) Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA. (21) Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA. (22) Division of Immunology and Rheumatology, Department of Medicine, Stanford University, Stanford, CA, USA. Division of Computational Medicine, Department of Medicine, Stanford University, Stanford, CA, USA. (23) Division of Immunology and Rheumatology, Department of Medicine, Stanford University, Stanford, CA, USA. Division of Computational Medicine, Department of Medicine, Stanford University, Stanford, CA, USA. Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA. Weill Cancer Hub West, Stanford University and University of California, San Francisco, CA, USA. (24) Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA. Weill Cancer Hub West, Stanford University and University of California, San Francisco, CA, USA. Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA, USA. UCSF Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA. (25) Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel. George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel. Dotan Center for Advanced Therapies, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel. (26) Weill Cancer Hub West, Stanford University and University of California, San Francisco, CA, USA. Department of Pathology, University of California San Francisco, San Francisco, CA, USA. (27) Department of Medicine, University of California San Francisco, San Francisco, CA, USA. Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA. Weill Cancer Hub West, Stanford University and University of California, San Francisco, CA, USA. UCSF Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA. (28) Department of Medicine, University of California San Francisco, San Francisco, CA, USA. Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA. Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA. Weill Cancer Hub West, Stanford University and University of California, San Francisco, CA, USA. (29) Department of OB/Gyn, Center for Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA. (30) Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA. (31) Department of Microbiology and Immunology and Howard Hughes Medical Institute, University of California San Francisco, San Francisco, CA, USA. (32) Department of Medicine, University of California San Francisco, San Francisco, CA, USA. Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA. Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA. Weill Cancer Hub West, Stanford University and University of California, San Francisco, CA, USA. UCSF Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA. Institute for Human Genetics (IHG), University of California San Francisco, San Francisco, CA, USA. Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA. Innovative Genomics Institute, University of California Berkeley, Berkeley, CA, USA. (33) Department of Medicine, University of California San Francisco, San Francisco, CA, USA. julia.carnevale@ucsf.edu. Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA. julia.carnevale@ucsf.edu. Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA. julia.carnevale@ucsf.edu. Weill Cancer Hub West, Stanford University and University of California, San Francisco, CA, USA. julia.carnevale@ucsf.edu. UCSF Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA. julia.carnevale@ucsf.edu.

Author Info:

Author Info:

Author Info: (1) Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA; Department of Genetics, Stanford University, Stanford, CA, USA. Electronic address: ronghui.zhu@gladston

Author Info: (1) Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA; Department of Genetics, Stanford University, Stanford, CA, USA. Electronic address: ronghui.zhu@gladstone.ucsf.edu. (2) Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA; Department of Genetics, Stanford University, Stanford, CA, USA. Electronic address: emmadann@stanford.edu. (3) Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA. (4) Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA. (5) Department of Biomedical Data Science, Stanford University, Stanford, CA, USA. (6) Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA; University of San Francisco, San Francisco, CA, USA. (7) Department of Genetics, Stanford University, Stanford, CA, USA. (8) Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA; Department of Genetics, Stanford University, Stanford, CA, USA; Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. (9) Department of Genetics, Stanford University, Stanford, CA, USA; Department of Pathology, Stanford University, Stanford, CA, USA; Arc Institute, Palo Alto, CA, USA. (10) Department of Pathology, Stanford University, Stanford, CA, USA; Arc Institute, Palo Alto, CA, USA; Program in Immunology, Stanford University, Stanford, CA, USA; Stanford Cancer Institute, Stanford University, Stanford, CA, USA; Weill Foundation West Coast Cancer Hub, Stanford, CA, USA. (11) Department of Genetics, Stanford University, Stanford, CA, USA; Department of Pathology, Stanford University, Stanford, CA, USA; Program in Immunology, Stanford University, Stanford, CA, USA; Stanford Cancer Institute, Stanford University, Stanford, CA, USA; Weill Foundation West Coast Cancer Hub, Stanford, CA, USA. (12) Department of Genetics, Stanford University, Stanford, CA, USA; Department of Biology, Stanford University, Stanford, CA, USA. Electronic address: pritch@stanford.edu. (13) Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA; Weill Foundation West Coast Cancer Hub, Stanford, CA, USA; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA; University of California, San Francisco Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA; Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA; Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA. Electronic address: alex.marson@gladstone.ucsf.edu.

Author Info: (1) Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, San Francisco (UCSF), San Francisco, CA, USA; Department of Urology, Univ

Author Info: (1) Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, San Francisco (UCSF), San Francisco, CA, USA; Department of Urology, University of California, San Francisco (UCSF), San Francisco, CA, USA; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco (UCSF), San Francisco, CA, USA. (2) Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, San Francisco (UCSF), San Francisco, CA, USA; Department of Urology, University of California, San Francisco (UCSF), San Francisco, CA, USA; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco (UCSF), San Francisco, CA, USA. (3) Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, San Francisco (UCSF), San Francisco, CA, USA; Department of Urology, University of California, San Francisco (UCSF), San Francisco, CA, USA; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco (UCSF), San Francisco, CA, USA. (4) Division of Hematology and Oncology, Department of Medicine, University of California, San Francisco (UCSF), San Francisco, CA, USA. (5) Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, San Francisco (UCSF), San Francisco, CA, USA; Department of Urology, University of California, San Francisco (UCSF), San Francisco, CA, USA; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco (UCSF), San Francisco, CA, USA. (6) Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, San Francisco (UCSF), San Francisco, CA, USA; Department of Urology, University of California, San Francisco (UCSF), San Francisco, CA, USA; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco (UCSF), San Francisco, CA, USA. (7) Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan. (8) Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, San Francisco (UCSF), San Francisco, CA, USA; Department of Urology, University of California, San Francisco (UCSF), San Francisco, CA, USA; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco (UCSF), San Francisco, CA, USA. (9) AIVITA Biomedical, Irvine, CA, USA. (10) Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan. (11) Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco (UCSF), San Francisco, CA, USA; Division of Hematology and Oncology, Department of Medicine, University of California, San Francisco (UCSF), San Francisco, CA, USA. (12) AIVITA Biomedical, Irvine, CA, USA. (13) AIVITA Biomedical, Irvine, CA, USA. (14) Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco (UCSF), San Francisco, CA, USA; Division of Hematology and Oncology, Department of Medicine, University of California, San Francisco (UCSF), San Francisco, CA, USA. (15) Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan. (16) Division of Hematology and Oncology, Department of Medicine, University of California, San Francisco (UCSF), San Francisco, CA, USA. (17) Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, San Francisco (UCSF), San Francisco, CA, USA; Department of Urology, University of California, San Francisco (UCSF), San Francisco, CA, USA; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco (UCSF), San Francisco, CA, USA. Electronic address: robert.blelloch@ucsf.edu.