Author Info: Guangdong Provincial Key laboratory of Colorectal and Pelvic Floor Disease, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, China Zhitong Niu, Bing Cheng,

Author Info: Guangdong Provincial Key laboratory of Colorectal and Pelvic Floor Disease, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, China Zhitong Niu, Bing Cheng, Yue Jiang, Yingzhen Weng, Qian Xiao, Chaoying Wei, Qiufeng Liu, Jinxin Chen, Xiaojian Wu & Wenyu WangGuangdong Institute of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, China Zhitong Niu, Bing Cheng, Yue Jiang, Yingzhen Weng, Qian Xiao, Chaoying Wei, Qiufeng Liu, Jinxin Chen, Xiaojian Wu & Wenyu WangBiomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, China Zhitong Niu, Bing Cheng, Yue Jiang, Yingzhen Weng, Qian Xiao, Guojie Long, Chaoying Wei, Qiufeng Liu, Jinxin Chen, Xiaofeng Wen, Yufeng Chen, Yan Huang, Weidong Pan, Xiaojian Wu & Wenyu WangDepartment of General Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, China Guojie Long, Xiaofeng Wen, Yufeng Chen, Weidong Pan & Xiaojian WuThe First Affiliated Hospital of Jinan University, Guangzhou, 510630, China Panpan WangDepartment of Pathology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, China Yan HuangState Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China Jing TanLaboratory of Cancer Epigenome, Division of Medical Sciences, National Cancer Centre Singapore, Singapore, 168583, Singapore Jing TanHainan Academy of Medical Science, Hainan Medical University, Haikou, 571199, China Jing TanPharmacy college, Jinan University, Guangzhou, 510632, China Ronghua ZhangCancer research institute, Jinan University, Guangzhou, 510632, China Ronghua ZhangGenome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Biopolis, 138672, Singapore Qiang YuDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore Qiang YuCancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, 169857, Singapore Qiang Yu

Author Info: (1) David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA. Department of Chemical Engineering, Massachusetts Institute

Author Info: (1) David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA. Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. (2) David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA. Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. (3) David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA. Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA. (4) David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA. Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. (5) David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA. Harvard and MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA. (6) David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA. Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA. (7) David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA. Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. (8) David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA. Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. (9) David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA. Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. (10) David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA. Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA. (11) David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA. Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. (12) David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA. Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. (13) David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA. Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. (14) David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA. (15) David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA. Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA. Harvard and MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA. Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA. Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA. (16) David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA. dgander@mit.edu. Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. dgander@mit.edu. Harvard and MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA. dgander@mit.edu. Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA. dgander@mit.edu. Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA. dgander@mit.edu.

Author Info: (1) University of California, Los Angeles Los Angeles, CA United States. ROR: https://ror.org/046rm7j60 (2) University of California, Los Angeles LA, CA United States. ROR: https:/

Author Info: (1) University of California, Los Angeles Los Angeles, CA United States. ROR: https://ror.org/046rm7j60 (2) University of California, Los Angeles LA, CA United States. ROR: https://ror.org/046rm7j60 (3) University of California, Los Angeles Los Angeles, CA United States. ROR: https://ror.org/046rm7j60 (4) Gladstone Institutes San Francisco, California United States. ROR: https://ror.org/038321296 (5) Gladstone Institutes San Francisco, California United States. ROR: https://ror.org/038321296 (6) University of California, San Francisco San Francisco, CA United States. ROR: https://ror.org/043mz5j54 (7) University of California, Los Angeles Los Angeles, CA United States. ROR: https://ror.org/046rm7j60 (8) University of California, Los Angeles Los Angeles, CA United States. ROR: https://ror.org/046rm7j60 (9) University of California, Los Angeles Los Angeles, CA United States. ROR: https://ror.org/046rm7j60 (10) University of California, Los Angeles Los Angeles, CA United States. ROR: https://ror.org/046rm7j60 (11) Dana-Farber Cancer Institute Boston United States. ROR: https://ror.org/02jzgtq86 (12) Max Planck Institute of Biochemistry Martinsried Germany. ROR: https://ror.org/04py35477 (13) University of California, Los Angeles Los Angeles, CA United States. ROR: https://ror.org/046rm7j60 (14) University of California, San Francisco San Francisco, CA United States. ROR: https://ror.org/043mz5j54 (15) University of California, Los Angeles Los Angeles, CA United States. ROR: https://ror.org/046rm7j60 (16) University of California, Los Angeles Los Angeles, CA United States. ROR: https://ror.org/046rm7j60

Author Info: (1) Gladstone Institutes San Francisco, California United States. ROR: https://ror.org/038321296 (2) Gladstone Institutes San Francisco, California United States. ROR: https://ror.

Author Info: (1) Gladstone Institutes San Francisco, California United States. ROR: https://ror.org/038321296 (2) Gladstone Institutes San Francisco, California United States. ROR: https://ror.org/038321296 (3) H™pital Saint-Louis Paris France. ROR: https://ror.org/049am9t04 (4) University of California San Francisco Medical Center United States. ROR: https://ror.org/01t8svj65 (5) University of California, San Francisco San Francisco, CA United States. ROR: https://ror.org/043mz5j54 (6) University of California, San Francisco San Francisco, CA United States. ROR: https://ror.org/043mz5j54 (7) University of California, San Francisco San Francisco, CA United States. ROR: https://ror.org/043mz5j54 (8) Gladstone Institutes United States. ROR: https://ror.org/038321296 (9) University of California, San Francisco San Francisco, CA United States. ROR: https://ror.org/043mz5j54 (10) University of California, San Francisco San Francisco, CA United States. ROR: https://ror.org/043mz5j54 (11) University of California, San Francisco San Francisco, CA United States. ROR: https://ror.org/043mz5j54 (12) University of California, San Francisco San Francisco, CA United States. ROR: https://ror.org/043mz5j54 (13) UCSF San Francisco, CA United States. (14) Tango Therapeutics (United States) Boston, Massachusetts United States. ROR: https://ror.org/003x6t567 (15) University of California, San Francisco San Francisco, California United States. ROR: https://ror.org/043mz5j54 (16) University of California, San Francisco San Francisco, California United States. ROR: https://ror.org/043mz5j54 (17) University of California, San Francisco San Francisco, CA United States. ROR: https://ror.org/043mz5j54 (18) University of California, San Francisco United States. ROR: https://ror.org/043mz5j54 (19) Gladstone Institutes San Francisco, California United States. ROR: https://ror.org/038321296 (20) UCSF San Francisco, CA United States. (21) University of California, San Francisco San Francisco, CA United States. ROR: https://ror.org/043mz5j54

Author Info: (1) The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, Fujian 35002

Author Info: (1) The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, Fujian 350025, China; The Liver Center of Fujian Province, Fujian Medical University, Fuzhou, Fujian 350025, China. (2) Department of Radiotherapy, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, Fujian 350025, China. (3) The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, Fujian 350025, China; The Liver Center of Fujian Province, Fujian Medical University, Fuzhou, Fujian 350025, China. (4) The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, Fujian 350025, China; The Liver Center of Fujian Province, Fujian Medical University, Fuzhou, Fujian 350025, China. (5) Department of Radiotherapy, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, Fujian 350025, China. (6) Department of Radiotherapy, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, Fujian 350025, China. (7) The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, Fujian 350025, China; The Liver Center of Fujian Province, Fujian Medical University, Fuzhou, Fujian 350025, China. (8) The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, Fujian 350025, China; The Liver Center of Fujian Province, Fujian Medical University, Fuzhou, Fujian 350025, China. (9) The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, Fujian 350025, China; The Liver Center of Fujian Province, Fujian Medical University, Fuzhou, Fujian 350025, China. (10) The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, Fujian 350025, China; The Liver Center of Fujian Province, Fujian Medical University, Fuzhou, Fujian 350025, China. (11) The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, Fujian 350025, China; The Liver Center of Fujian Province, Fujian Medical University, Fuzhou, Fujian 350025, China. (12) The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, Fujian 350025, China; The Liver Center of Fujian Province, Fujian Medical University, Fuzhou, Fujian 350025, China. (13) Department of Radiotherapy, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, Fujian 350025, China. Electronic address: fjjhb8@sina.com. (14) The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, Fujian 350025, China; The Liver Center of Fujian Province, Fujian Medical University, Fuzhou, Fujian 350025, China. Electronic address: caizhixiong1985@163.com. (15) The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, Fujian 350025, China; The Liver Center of Fujian Province, Fujian Medical University, Fuzhou, Fujian 350025, China. Electronic address: xiaoloong.liu@gmail.com.

Author Info: (1) Zhejiang Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang Key Laboratory of Frontier Medical Research on Cancer Metabolism, and Institute of Transl

Author Info: (1) Zhejiang Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang Key Laboratory of Frontier Medical Research on Cancer Metabolism, and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China; Institute of Fundamental and Transdisciplinary Research, Zhejiang University Cancer Center, Zhejiang University, Hangzhou, Zhejiang 310029, China; The Center for Translational Research, The Second Affiliated Hospital and Institute of Translational Medicine, Zhejiang University, Hangzhou, Zhejiang 310029, China. (2) Department of Gastroenterology, Songjiang Research Institute, Shanghai Key Laboratory of Emotions and Affective Disorders, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 201600, China. Electronic address: dongguo@shsmu.edu.cn. (3) Zhejiang Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang Key Laboratory of Frontier Medical Research on Cancer Metabolism, and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China; Institute of Fundamental and Transdisciplinary Research, Zhejiang University Cancer Center, Zhejiang University, Hangzhou, Zhejiang 310029, China; The Center for Translational Research, The Second Affiliated Hospital and Institute of Translational Medicine, Zhejiang University, Hangzhou, Zhejiang 310029, China. (4) Department of General Surgery, Pancreatic Disease Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. (5) Zhejiang Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang Key Laboratory of Frontier Medical Research on Cancer Metabolism, and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China. (6) Zhejiang Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang Key Laboratory of Frontier Medical Research on Cancer Metabolism, and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China; Institute of Fundamental and Transdisciplinary Research, Zhejiang University Cancer Center, Zhejiang University, Hangzhou, Zhejiang 310029, China; The Center for Translational Research, The Second Affiliated Hospital and Institute of Translational Medicine, Zhejiang University, Hangzhou, Zhejiang 310029, China. (7) Department of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China. (8) Zhejiang Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang Key Laboratory of Frontier Medical Research on Cancer Metabolism, and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China; Institute of Fundamental and Transdisciplinary Research, Zhejiang University Cancer Center, Zhejiang University, Hangzhou, Zhejiang 310029, China; The Center for Translational Research, The Second Affiliated Hospital and Institute of Translational Medicine, Zhejiang University, Hangzhou, Zhejiang 310029, China. (9) Zhejiang Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang Key Laboratory of Frontier Medical Research on Cancer Metabolism, and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China; Institute of Fundamental and Transdisciplinary Research, Zhejiang University Cancer Center, Zhejiang University, Hangzhou, Zhejiang 310029, China; The Center for Translational Research, The Second Affiliated Hospital and Institute of Translational Medicine, Zhejiang University, Hangzhou, Zhejiang 310029, China. (10) Zhejiang Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang Key Laboratory of Frontier Medical Research on Cancer Metabolism, and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China; Institute of Fundamental and Transdisciplinary Research, Zhejiang University Cancer Center, Zhejiang University, Hangzhou, Zhejiang 310029, China; The Center for Translational Research, The Second Affiliated Hospital and Institute of Translational Medicine, Zhejiang University, Hangzhou, Zhejiang 310029, China. (11) Zhejiang Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang Key Laboratory of Frontier Medical Research on Cancer Metabolism, and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China; Institute of Fundamental and Transdisciplinary Research, Zhejiang University Cancer Center, Zhejiang University, Hangzhou, Zhejiang 310029, China; The Center for Translational Research, The Second Affiliated Hospital and Institute of Translational Medicine, Zhejiang University, Hangzhou, Zhejiang 310029, China. (12) Zhejiang Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang Key Laboratory of Frontier Medical Research on Cancer Metabolism, and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China; Institute of Fundamental and Transdisciplinary Research, Zhejiang University Cancer Center, Zhejiang University, Hangzhou, Zhejiang 310029, China; The Center for Translational Research, The Second Affiliated Hospital and Institute of Translational Medicine, Zhejiang University, Hangzhou, Zhejiang 310029, China. (13) Zhejiang Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang Key Laboratory of Frontier Medical Research on Cancer Metabolism, and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China; Institute of Fundamental and Transdisciplinary Research, Zhejiang University Cancer Center, Zhejiang University, Hangzhou, Zhejiang 310029, China; The Center for Translational Research, The Second Affiliated Hospital and Institute of Translational Medicine, Zhejiang University, Hangzhou, Zhejiang 310029, China. (14) Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Zhejiang Provincial Clinical Research Center for Cancer, Department of Medical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Cancer Center, Zhejiang University, Hangzhou, Zhejiang 310058, China. (15) Zhejiang Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang Key Laboratory of Frontier Medical Research on Cancer Metabolism, and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China; Institute of Fundamental and Transdisciplinary Research, Zhejiang University Cancer Center, Zhejiang University, Hangzhou, Zhejiang 310029, China; The Center for Translational Research, The Second Affiliated Hospital and Institute of Translational Medicine, Zhejiang University, Hangzhou, Zhejiang 310029, China. (16) Zhejiang Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang Key Laboratory of Frontier Medical Research on Cancer Metabolism, and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China. (17) Zhejiang Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang Key Laboratory of Frontier Medical Research on Cancer Metabolism, and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China; Institute of Fundamental and Transdisciplinary Research, Zhejiang University Cancer Center, Zhejiang University, Hangzhou, Zhejiang 310029, China; The Center for Translational Research, The Second Affiliated Hospital and Institute of Translational Medicine, Zhejiang University, Hangzhou, Zhejiang 310029, China. (18) Center for Regeneration and Aging Medicine, The Fourth Affiliated Hospital of School of Medicine, International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, Zhejiang 322000, China. (19) Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Zhejiang Provincial Clinical Research Center for Cancer, Department of Medical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Cancer Center, Zhejiang University, Hangzhou, Zhejiang 310058, China. (20) Zhejiang Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang Key Laboratory of Frontier Medical Research on Cancer Metabolism, and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China; Institute of Fundamental and Transdisciplinary Research, Zhejiang University Cancer Center, Zhejiang University, Hangzhou, Zhejiang 310029, China; The Center for Translational Research, The Second Affiliated Hospital and Institute of Translational Medicine, Zhejiang University, Hangzhou, Zhejiang 310029, China. (21) Department of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China. Electronic address: wam@zju.edu.cn. (22) Department of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China. Electronic address: dingyuan@zju.edu.cn. (23) Zhejiang Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang Key Laboratory of Frontier Medical Research on Cancer Metabolism, and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China; Institute of Fundamental and Transdisciplinary Research, Zhejiang University Cancer Center, Zhejiang University, Hangzhou, Zhejiang 310029, China; The Center for Translational Research, The Second Affiliated Hospital and Institute of Translational Medicine, Zhejiang University, Hangzhou, Zhejiang 310029, China. Electronic address: zhiminlu@zju.edu.cn.

Author Info: (1) UPMC Hillman Cancer Center, Pittsburgh, PA 15206, USA; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15206, USA; Tumor Microenvironment

Author Info: (1) UPMC Hillman Cancer Center, Pittsburgh, PA 15206, USA; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15206, USA; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA 15206, USA. (2) UPMC Hillman Cancer Center, Pittsburgh, PA 15206, USA; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15206, USA; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA 15206, USA; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. (3) UPMC Hillman Cancer Center, Pittsburgh, PA 15206, USA; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15206, USA; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA 15206, USA; Program in Microbiology and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. (4) Division of Laboratory Animal Resources, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA. (5) UPMC Hillman Cancer Center, Pittsburgh, PA 15206, USA; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15206, USA; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA 15206, USA; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. (6) UPMC Hillman Cancer Center, Pittsburgh, PA 15206, USA; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15206, USA; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA 15206, USA. (7) UPMC Hillman Cancer Center, Pittsburgh, PA 15206, USA; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15206, USA; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA 15206, USA; Program in Microbiology and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. (8) UPMC Hillman Cancer Center, Pittsburgh, PA 15206, USA; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15206, USA; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA 15206, USA. (9) UPMC Hillman Cancer Center, Pittsburgh, PA 15206, USA. (10) UPMC Hillman Cancer Center, Pittsburgh, PA 15206, USA; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15206, USA; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA 15206, USA. (11) Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA; Health Sciences Mass Spectrometry Core, University of Pittsburgh, Pittsburgh, PA 15213, USA. (12) UPMC Hillman Cancer Center, Pittsburgh, PA 15206, USA; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15206, USA; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA 15206, USA; Cellular and Molecular Pathology Program, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. (13) Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA; Health Sciences Mass Spectrometry Core, University of Pittsburgh, Pittsburgh, PA 15213, USA. (14) UPMC Hillman Cancer Center, Pittsburgh, PA 15206, USA; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15206, USA; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA 15206, USA. (15) UPMC Hillman Cancer Center, Pittsburgh, PA 15206, USA. (16) UPMC Hillman Cancer Center, Pittsburgh, PA 15206, USA; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15206, USA; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA 15206, USA; Center for Systems Immunology, Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15206, USA. (17) UPMC Hillman Cancer Center, Pittsburgh, PA 15206, USA; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15206, USA; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA 15206, USA. (18) UPMC Hillman Cancer Center, Pittsburgh, PA 15206, USA; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15206, USA; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA 15206, USA. Electronic address: overacre@pitt.edu.

Author Info: (1) Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USA; Center of Excellence for Cancer Immunology and Immunotherapy, University of Michigan Rogel

Author Info: (1) Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USA; Center of Excellence for Cancer Immunology and Immunotherapy, University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA. (2) Department of Molecular and Cellular Physiology, Albany Medical College, Albany, NY, USA. (3) Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USA; Center of Excellence for Cancer Immunology and Immunotherapy, University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA; Graduate Program in Immunology, University of Michigan, Ann Arbor, MI, USA. (4) Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USA; Center of Excellence for Cancer Immunology and Immunotherapy, University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA. (5) Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA. (6) Department of Molecular & Physiology, University of Michigan, Ann Arbor, MI, USA. (7) Program in Cellular and Molecular Medicine, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA. (8) Program in Cellular and Molecular Medicine, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA. (9) Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA. (10) Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USA; Center of Excellence for Cancer Immunology and Immunotherapy, University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA. (11) Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USA; Center of Excellence for Cancer Immunology and Immunotherapy, University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA. (12) Department of Molecular & Physiology, University of Michigan, Ann Arbor, MI, USA. (13) Department of Molecular & Physiology, University of Michigan, Ann Arbor, MI, USA. (14) Program in Cellular and Molecular Medicine, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA. (15) Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia. (16) Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USA; Center of Excellence for Cancer Immunology and Immunotherapy, University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA. (17) Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USA; Center of Excellence for Cancer Immunology and Immunotherapy, University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA. (18) Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USA; Center of Excellence for Cancer Immunology and Immunotherapy, University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA; Graduate Program in Immunology, University of Michigan, Ann Arbor, MI, USA. (19) Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USA; Center of Excellence for Cancer Immunology and Immunotherapy, University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA; Graduate Program in Immunology, University of Michigan, Ann Arbor, MI, USA. (20) Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USA. (21) Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USA. (22) Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USA. (23) Cayman Chemical, Ann Arbor, MI, USA. (24) Cayman Chemical, Ann Arbor, MI, USA. (25) Department of Molecular & Physiology, University of Michigan, Ann Arbor, MI, USA; Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA. (26) Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USA; Center of Excellence for Cancer Immunology and Immunotherapy, University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA; Graduate Program in Immunology, University of Michigan, Ann Arbor, MI, USA. Electronic address: ilonak@umich.edu. (27) Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia. (28) Department of Molecular and Cellular Physiology, Albany Medical College, Albany, NY, USA. Electronic address: barrosm@amc.edu. (29) Program in Cellular and Molecular Medicine, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA. Electronic address: judy.lieberman@childrens.harvard.edu. (30) Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USA; Center of Excellence for Cancer Immunology and Immunotherapy, University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA; Graduate Program in Immunology, University of Michigan, Ann Arbor, MI, USA. Electronic address: wzou@umich.edu.

Author Info: (1) Light Chain Bioscience (Switzerland) Plan-les-Ouates Switzerland. ROR: https://ror.org/03a17f132 (2) Light Chain Bioscience (Switzerland) Plan-les-Ouates Switzerland. ROR: http

Author Info: (1) Light Chain Bioscience (Switzerland) Plan-les-Ouates Switzerland. ROR: https://ror.org/03a17f132 (2) Light Chain Bioscience (Switzerland) Plan-les-Ouates Switzerland. ROR: https://ror.org/03a17f132 (3) University of Geneva Geneva Switzerland. ROR: https://ror.org/01swzsf04 (4) Light Chain Bioscience (Switzerland) Plan-Les-Ouates, Geneva Switzerland. ROR: https://ror.org/03a17f132 (5) Light Chain Bioscience (Switzerland) Plan-Les-Ouates, Geneva Switzerland. ROR: https://ror.org/03a17f132 (6) Memorial Sloan Kettering Cancer Center New York City, New York United States. ROR: https://ror.org/02yrq0923 (7) Light Chain Bioscience. (8) Light Chain Bioscience (Switzerland) Plan-Les-Ouates, Geneva Switzerland. ROR: https://ror.org/03a17f132 (9) Geneva Medical School Geneva Switzerland. (10) University of Geneva Geneva Switzerland. ROR: https://ror.org/01swzsf04 (11) Light Chain Bioscience (Switzerland) Plan-les-Ouates, Geneva Switzerland. ROR: https://ror.org/03a17f132

Author Info: (1) Department of Microbiome Science, Max Planck Institute for Biology, TŸbingen, Germany. Controlling Microbes to Fight Infections (CMFI) Cluster of Excellence, TŸbingen, Germany.

Author Info: (1) Department of Microbiome Science, Max Planck Institute for Biology, TŸbingen, Germany. Controlling Microbes to Fight Infections (CMFI) Cluster of Excellence, TŸbingen, Germany. (2) Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA. (3) Department of Microbiome Science, Max Planck Institute for Biology, TŸbingen, Germany. Controlling Microbes to Fight Infections (CMFI) Cluster of Excellence, TŸbingen, Germany. (4) Department of Microbiome Science, Max Planck Institute for Biology, TŸbingen, Germany. Controlling Microbes to Fight Infections (CMFI) Cluster of Excellence, TŸbingen, Germany. (5) Microbiome-Host Interactions, Institut Pasteur, UniversitŽ Paris CitŽ, Paris, France. (6) Department of Microbiome Science, Max Planck Institute for Biology, TŸbingen, Germany. Controlling Microbes to Fight Infections (CMFI) Cluster of Excellence, TŸbingen, Germany. (7) Department of Microbiome Science, Max Planck Institute for Biology, TŸbingen, Germany. Controlling Microbes to Fight Infections (CMFI) Cluster of Excellence, TŸbingen, Germany. (8) Mass Spectrometry Facility, Max Planck Institute for Biology TŸbingen, TŸbingen, Germany. (9) Department of Pediatrics and Child Health, University of Manitoba, Manitoba, Canada. (10) Department of Pediatrics; Center for Microbiome Innovation; Department of Computer Science and Engineering; Shu Chien-Gene Lay Department of Bioengineering; Halõcõo_lu Data Science Institute, University of California San Diego, La Jolla, CA, USA. Hong Kong University of Science and Technology Jockey Club Institute for Advanced Study, Hong Kong University of Science and Technology, Hong Kong SAR, China. (11) Department of Pediatrics and Child Health, University of Manitoba, Manitoba, Canada. (12) Department of Pediatrics and Child Health, University of Manitoba, Manitoba, Canada. (13) Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, OT, Canada. (14) Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA. (15) Department of Microbiome Science, Max Planck Institute for Biology, TŸbingen, Germany. Controlling Microbes to Fight Infections (CMFI) Cluster of Excellence, TŸbingen, Germany. (16) Department of Microbiome Science, Max Planck Institute for Biology, TŸbingen, Germany. Controlling Microbes to Fight Infections (CMFI) Cluster of Excellence, TŸbingen, Germany. (17) Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA. (18) Departments of Medicine and of Epidemiology and Population Health, Stanford University, Stanford, CA, USA. (19) Controlling Microbes to Fight Infections (CMFI) Cluster of Excellence, TŸbingen, Germany. Institute for Tropical Medicine, University of TŸbingen, TŸbingen, Germany. (20) Microbiome-Host Interactions, Institut Pasteur, UniversitŽ Paris CitŽ, Paris, France. (21) Controlling Microbes to Fight Infections (CMFI) Cluster of Excellence, TŸbingen, Germany. Interfaculty Institute of Microbiology and Infection Medicine, University of TŸbingen, TŸbingen, Germany. Centre de Recherches Medicales de LambarŽnŽ, LambarŽnŽ, Gabon. German Center for Infection Research (DZIF), partner site TŸbingen, TŸbingen, Germany. (22) Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA. (23) Controlling Microbes to Fight Infections (CMFI) Cluster of Excellence, TŸbingen, Germany. Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA. Centre de Recherches Medicales de LambarŽnŽ, LambarŽnŽ, Gabon. (24) Department of Microbiome Science, Max Planck Institute for Biology, TŸbingen, Germany. Controlling Microbes to Fight Infections (CMFI) Cluster of Excellence, TŸbingen, Germany.