Author Info: (1) Koch Institute at MIT, Cambridge, MA, USA. Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA. (2) Koch Institute at MIT, Cambridge, MA, USA. Dana

Author Info: (1) Koch Institute at MIT, Cambridge, MA, USA. Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA. (2) Koch Institute at MIT, Cambridge, MA, USA. Dana-Farber Cancer Institute, Boston, MA, USA. The Broad Institute of MIT and Harvard, Cambridge, MA, USA. (3) Dana-Farber Cancer Institute, Boston, MA, USA. The Broad Institute of MIT and Harvard, Cambridge, MA, USA. Harvard Medical School, Boston, MA, USA. (4) Dana-Farber Cancer Institute, Boston, MA, USA. The Broad Institute of MIT and Harvard, Cambridge, MA, USA. (5) The Broad Institute of MIT and Harvard, Cambridge, MA, USA. (6) Dana-Farber Cancer Institute, Boston, MA, USA. (7) The Broad Institute of MIT and Harvard, Cambridge, MA, USA. (8) Dana-Farber Cancer Institute, Boston, MA, USA. The Broad Institute of MIT and Harvard, Cambridge, MA, USA. (9) The Broad Institute of MIT and Harvard, Cambridge, MA, USA. (10) Dana-Farber Cancer Institute, Boston, MA, USA. (11) Program in Immunology, Fred Hutchinson Cancer Center, Seattle, WA, USA. (12) Dana-Farber Cancer Institute, Boston, MA, USA. (13) Koch Institute at MIT, Cambridge, MA, USA. Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA. (14) Dana-Farber Cancer Institute, Boston, MA, USA. (15) Dana-Farber Cancer Institute, Boston, MA, USA. Harvard Medical School, Boston, MA, USA. Hale Family Center for Pancreatic Cancer Research at DFCI, Boston, MA, USA. (16) Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark. (17) The Broad Institute of MIT and Harvard, Cambridge, MA, USA. (18) Koch Institute at MIT, Cambridge, MA, USA. (19) Koch Institute at MIT, Cambridge, MA, USA. (20) Dana-Farber Cancer Institute, Boston, MA, USA. Harvard Medical School, Boston, MA, USA. Hale Family Center for Pancreatic Cancer Research at DFCI, Boston, MA, USA. (21) Dana-Farber Cancer Institute, Boston, MA, USA. The Broad Institute of MIT and Harvard, Cambridge, MA, USA. Harvard Medical School, Boston, MA, USA. Hale Family Center for Pancreatic Cancer Research at DFCI, Boston, MA, USA. (22) Dana-Farber Cancer Institute, Boston, MA, USA. The Broad Institute of MIT and Harvard, Cambridge, MA, USA. Harvard Medical School, Boston, MA, USA. (23) Program in Immunology, Fred Hutchinson Cancer Center, Seattle, WA, USA. Division of Medical Oncology, Department of Medicine, University of Washington, Seattle, WA, USA. Department of Immunology, University of Washington, Seattle, WA, USA. (24) Dana-Farber Cancer Institute, Boston, MA, USA. The Broad Institute of MIT and Harvard, Cambridge, MA, USA. Harvard Medical School, Boston, MA, USA. Hale Family Center for Pancreatic Cancer Research at DFCI, Boston, MA, USA. (25) Dana-Farber Cancer Institute, Boston, MA, USA. The Broad Institute of MIT and Harvard, Cambridge, MA, USA. (26) The Broad Institute of MIT and Harvard, Cambridge, MA, USA. (27) Koch Institute at MIT, Cambridge, MA, USA. Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA. (28) Koch Institute at MIT, Cambridge, MA, USA. Dana-Farber Cancer Institute, Boston, MA, USA. The Broad Institute of MIT and Harvard, Cambridge, MA, USA. Harvard Medical School, Boston, MA, USA. Hale Family Center for Pancreatic Cancer Research at DFCI, Boston, MA, USA.

Author Info: (1) Department of Neurology and Neurosciences, Stanford School of Medicine, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.

Author Info: (1) Department of Neurology and Neurosciences, Stanford School of Medicine, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA. (2) Department of Neurology and Neurosciences, Stanford School of Medicine, Stanford, CA 94305, USA. (3) Department of Pediatrics, Stanford School of Medicine, Stanford, CA 94305, USA. (4) Department of Neurology and Neurosciences, Stanford School of Medicine, Stanford, CA 94305, USA. (5) Neuroscience Institute, NYU Grossman School of Medicine, New York, NY 10016, USA. (6) Department of Pediatrics, Stanford School of Medicine, Stanford, CA 94305, USA. (7) Department of Neurology and Neurosciences, Stanford School of Medicine, Stanford, CA 94305, USA. (8) Department of Neurology and Neurosciences, Stanford School of Medicine, Stanford, CA 94305, USA. (9) Department of Neurology and Neurosciences, Stanford School of Medicine, Stanford, CA 94305, USA. (10) Department of Neurology and Neurosciences, Stanford School of Medicine, Stanford, CA 94305, USA. (11) Department of Neurology and Neurosciences, Stanford School of Medicine, Stanford, CA 94305, USA. (12) Department of Pediatrics, Stanford School of Medicine, Stanford, CA 94305, USA. (13) Department of Neurology and Neurosciences, Stanford School of Medicine, Stanford, CA 94305, USA. (14) Department of Neurology and Neurosciences, Stanford School of Medicine, Stanford, CA 94305, USA. (15) Department of Neurology and Neurosciences, Stanford School of Medicine, Stanford, CA 94305, USA. (16) Department of Neurology and Neurosciences, Stanford School of Medicine, Stanford, CA 94305, USA. (17) Department of Neurology and Neurosciences, Stanford School of Medicine, Stanford, CA 94305, USA. (18) Department of Neurology and Neurosciences, Stanford School of Medicine, Stanford, CA 94305, USA. (19) Department of Neurology and Neurosciences, Stanford School of Medicine, Stanford, CA 94305, USA. (20) Department of Neurology and Neurosciences, Stanford School of Medicine, Stanford, CA 94305, USA. (21) Department of Neurology and Neurosciences, Stanford School of Medicine, Stanford, CA 94305, USA. (22) Brain immunology and Glia (BIG) Center and Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63130, USA. (23) Brain immunology and Glia (BIG) Center and Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63130, USA. (24) Brain immunology and Glia (BIG) Center and Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63130, USA. (25) Neuroscience Institute, NYU Grossman School of Medicine, New York, NY 10016, USA; Department of Neuroscience and Physiology, NYU Grossman School of Medicine, New York, NY 10016, USA; Department of Ophthalmology, NYU Grossman School of Medicine, New York, NY 10016, USA; Parekh Center for Interdisciplinary Neurology, NYU Grossman School of Medicine, New York, NY 10016, USA. (26) Department of Pediatrics, Stanford School of Medicine, Stanford, CA 94305, USA; Center for Cancer Cellular Therapy, Stanford School of Medicine, Stanford, CA 94305, USA; Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. (27) Department of Pediatrics, Stanford School of Medicine, Stanford, CA 94305, USA; Center for Cancer Cellular Therapy, Stanford School of Medicine, Stanford, CA 94305, USA. (28) Department of Neurology and Neurosciences, Stanford School of Medicine, Stanford, CA 94305, USA; Department of Pediatrics, Stanford School of Medicine, Stanford, CA 94305, USA; Center for Cancer Cellular Therapy, Stanford School of Medicine, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA. Electronic address: mmonje@stanford.edu.

Author Info: (1) Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Genomic Medicine, The University of Te

Author Info: (1) Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. (2) Institute for Data Science in Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. (3) Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. (4) Department of Medicine, Baylor College of Medicine, Houston, TX, USA. (5) Clinical Research Center in Hiroshima, Hiroshima University Hospital, Hiroshima, Japan. (6) Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. (7) Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. (8) Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. (9) Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. (10) Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. (11) Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. (12) Department of Pathology, NYU Langone Health, New York, NY, USA. (13) Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. (14) Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. (15) Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. (16) Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. (17) Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. (18) Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. (19) Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. (20) Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. (21) Department of Translational Molecular Pathology and Sheikn Ahmed Center for Pancreatic Cancer Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. (22) Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. (23) Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. (24) Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. (25) Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. (26) Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. (27) Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. (28) Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. (29) Department of Medicine, NYU Grossman School of Medicine, New York, NY, USA. (30) Department of Medicine, NYU Grossman School of Medicine, New York, NY, USA; Cardiothoracic Surgery, NYU Grossman School of Medicine, New York, NY, USA. (31) Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. (32) Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. (33) Department of Cellular and Molecular Medicine, UC San Diego, La Jolla, CA, USA. (34) Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. (35) Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. (36) Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. (37) Department of Pathology Informatics, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan. (38) Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. (39) Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. (40) Department of Cardiothoracic Surgery, NYU Langone Health, New York, NY, USA. (41) Institute of Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, USA. (42) Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, CA, USA. (43) Department of Medicine, Baylor College of Medicine, Houston, TX, USA. (44) Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, USA. (45) Pathology & Laboratory Medicine, and Bioinformatics, Boston University, Boston, MA, USA. (46) Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. (47) UC San Diego School of Medicine, La Jolla, CA, USA. (48) Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. (49) Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. (50) Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. (51) Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. (52) Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address: jzhang20@mdanderson.org.

Author Info: (1) Department of Urology, Qilu Hospital, Cheeloo College of Medicine; Shandong Key Laboratory of Targeted Drug Delivery and Advanced Pharmaceutics, NMPA Key Laboratory for Technol

Author Info: (1) Department of Urology, Qilu Hospital, Cheeloo College of Medicine; Shandong Key Laboratory of Targeted Drug Delivery and Advanced Pharmaceutics, NMPA Key Laboratory for Technology Research and Evaluation of Drug Products and Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China. wjing1@sdu.edu.cn. (2) Department of Urology, Qilu Hospital, Cheeloo College of Medicine; Shandong Key Laboratory of Targeted Drug Delivery and Advanced Pharmaceutics, NMPA Key Laboratory for Technology Research and Evaluation of Drug Products and Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China. (3) Department of Urology, Qilu Hospital, Cheeloo College of Medicine; Shandong Key Laboratory of Targeted Drug Delivery and Advanced Pharmaceutics, NMPA Key Laboratory for Technology Research and Evaluation of Drug Products and Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China. (4) Department of Urology, Qilu Hospital, Cheeloo College of Medicine; Shandong Key Laboratory of Targeted Drug Delivery and Advanced Pharmaceutics, NMPA Key Laboratory for Technology Research and Evaluation of Drug Products and Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China. (5) Department of Urology, Qilu Hospital, Cheeloo College of Medicine; Shandong Key Laboratory of Targeted Drug Delivery and Advanced Pharmaceutics, NMPA Key Laboratory for Technology Research and Evaluation of Drug Products and Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China. (6) Department of Urology, Qilu Hospital, Cheeloo College of Medicine; Shandong Key Laboratory of Targeted Drug Delivery and Advanced Pharmaceutics, NMPA Key Laboratory for Technology Research and Evaluation of Drug Products and Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China. (7) Department of Urology, Qilu Hospital, Cheeloo College of Medicine; Shandong Key Laboratory of Targeted Drug Delivery and Advanced Pharmaceutics, NMPA Key Laboratory for Technology Research and Evaluation of Drug Products and Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China. (8) Department of Urology, Qilu Hospital, Cheeloo College of Medicine; Shandong Key Laboratory of Targeted Drug Delivery and Advanced Pharmaceutics, NMPA Key Laboratory for Technology Research and Evaluation of Drug Products and Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China. (9) Department of Urology, Qilu Hospital, Cheeloo College of Medicine; Shandong Key Laboratory of Targeted Drug Delivery and Advanced Pharmaceutics, NMPA Key Laboratory for Technology Research and Evaluation of Drug Products and Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China. (10) Department of Urology, Qilu Hospital, Cheeloo College of Medicine; Shandong Key Laboratory of Targeted Drug Delivery and Advanced Pharmaceutics, NMPA Key Laboratory for Technology Research and Evaluation of Drug Products and Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China. (11) Department of Urology, Qilu Hospital, Cheeloo College of Medicine; Shandong Key Laboratory of Targeted Drug Delivery and Advanced Pharmaceutics, NMPA Key Laboratory for Technology Research and Evaluation of Drug Products and Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China. (12) Department of Urology, Qilu Hospital, Cheeloo College of Medicine; Shandong Key Laboratory of Targeted Drug Delivery and Advanced Pharmaceutics, NMPA Key Laboratory for Technology Research and Evaluation of Drug Products and Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China. (13) Department of Urology, Qilu Hospital, Cheeloo College of Medicine; Shandong Key Laboratory of Targeted Drug Delivery and Advanced Pharmaceutics, NMPA Key Laboratory for Technology Research and Evaluation of Drug Products and Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China. (14) Department of Urology, Qilu Hospital, Cheeloo College of Medicine; Shandong Key Laboratory of Targeted Drug Delivery and Advanced Pharmaceutics, NMPA Key Laboratory for Technology Research and Evaluation of Drug Products and Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China. (15) Department of Urology, Qilu Hospital, Cheeloo College of Medicine; Shandong Key Laboratory of Targeted Drug Delivery and Advanced Pharmaceutics, NMPA Key Laboratory for Technology Research and Evaluation of Drug Products and Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China. (16) Department of Urology, Qilu Hospital, Cheeloo College of Medicine; Shandong Key Laboratory of Targeted Drug Delivery and Advanced Pharmaceutics, NMPA Key Laboratory for Technology Research and Evaluation of Drug Products and Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China. (17) Department of Urology, Qilu Hospital, Cheeloo College of Medicine; Shandong Key Laboratory of Targeted Drug Delivery and Advanced Pharmaceutics, NMPA Key Laboratory for Technology Research and Evaluation of Drug Products and Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China. (18) Department of Urology, Qilu Hospital, Cheeloo College of Medicine; Shandong Key Laboratory of Targeted Drug Delivery and Advanced Pharmaceutics, NMPA Key Laboratory for Technology Research and Evaluation of Drug Products and Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China. (19) Department of Chemical and Biological Engineering, The Hong Kong University of Science and Technology, Kowloon, China. (20) Department of Urology, Qilu Hospital, Cheeloo College of Medicine; Shandong Key Laboratory of Targeted Drug Delivery and Advanced Pharmaceutics, NMPA Key Laboratory for Technology Research and Evaluation of Drug Products and Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China. shibenkangsdu@163.com. (21) Department of Urology, Qilu Hospital, Cheeloo College of Medicine; Shandong Key Laboratory of Targeted Drug Delivery and Advanced Pharmaceutics, NMPA Key Laboratory for Technology Research and Evaluation of Drug Products and Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China. xinyijiang@sdu.edu.cn.

Author Info: (1) Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA. chao.wang@moffitt.org. (2) Department of Biostatistics and Bioinformatics, H. Lee M

Author Info: (1) Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA. chao.wang@moffitt.org. (2) Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA. (3) Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA. (4) Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA. (5) Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA. (6) Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA. (7) Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA. (8) Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA. (9) Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA. (10) Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK. (11) Center for Immunotherapy and Precision Immuno-oncology, Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA. (12) Center for Immunotherapy and Precision Immuno-oncology, Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA. (13) Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA. Department of Integrative Immunobiology, Duke School of Medicine, Durham, NC, USA. Duke Cancer Institute, Duke University School of Medicine, Durham, NC, USA. (14) Department of Anatomic Pathology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA. (15) Department of Anatomic Pathology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA. (16) Proteomics & Metabolomics Core Facility, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA. (17) Molecular Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA. (18) Immune and Cellular Therapy Program, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA. (19) Immune and Cellular Therapy Program, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA. (20) Molecular Genomics Core Facility, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA. (21) Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA. Department of Radiation Oncology, Immunology, Cancer Biology, Mayo Clinic Alix College of Medicine & Health Sciences, Jacksonville, FL, USA. (22) Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA. (23) Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA. (24) Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA. Department of Integrative Immunobiology, Duke School of Medicine, Durham, NC, USA. Duke Cancer Institute, Duke University School of Medicine, Durham, NC, USA. (25) Duke Cancer Institute, Duke University School of Medicine, Durham, NC, USA. (26) Department of Thoracic Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA. (27) Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA. ben.creelan@moffitt.org. Department of Thoracic Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA. ben.creelan@moffitt.org.

Author Info: (1) Heinrich Heine University DŸsseldorf, DŸsseldorf, Germany. (2) Stefan-Morsch-Stiftung, Birkenfeld, Rheinland-Pfalz, Germany. (3) Institute of Human Genetics, University Medical

Author Info: (1) Heinrich Heine University DŸsseldorf, DŸsseldorf, Germany. (2) Stefan-Morsch-Stiftung, Birkenfeld, Rheinland-Pfalz, Germany. (3) Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, Hamburg, Hamburg, Germany. (4) Stefan Morsch Stiftung, Birkenfeld, Germany, Germany. (5) University Medical Center Hamburg-Eppendorf, Hamburg, Germany. (6) Laboratory for Brain Tumor Biology, Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, Germany. (7) University Medical Center Hamburg-Eppendorf, Hamburg, Germany. (8) University Medical Center Hamburg-Eppendorf, Hamburg, Germany. (9) University Medical Center Hamburg-Eppendorf, Hamburg, Germany. (10) University Medical Center Hamburg-Eppendorf, Hamburg, Germany. (11) Hubertus Wald University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. (12) University Medical Center Hamburg-Eppendorf, Hamburg, Germany. (13) Heinrich Heine University DŸsseldorf, DŸsseldorf, Germany. (14) University Medical Center Hamburg-Eppendorf, Hamburg, Hamburg, Germany. (15) University Medical Center Hamburg-Eppendorf, Germany. (16) University Medical Center Hamburg-Eppendorf, Hamburg, Germany. (17) University Medical Center Hamburg-Eppendorf, Hamburg, Germany. (18) Institute of Medical Microbiology and Hospital Hygiene, University Hospital DŸsseldorf, Heinrich Heine University DŸsseldorf, DŸsseldorf, Germany, Germany. (19) University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Author Info: (1) Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, 1515 Holcombe Blvd, Houston, TX, 77030, USA. sweathers@mdanderson.org. (2) Genomic Med

Author Info: (1) Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, 1515 Holcombe Blvd, Houston, TX, 77030, USA. sweathers@mdanderson.org. (2) Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, 1515 Holcombe Blvd, Houston, TX, 77030, USA. (3) Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, 1515 Holcombe Blvd, Houston, TX, 77030, USA. (4) Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, 1515 Holcombe Blvd, Houston, TX, 77030, USA. (5) Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, 1515 Holcombe Blvd, Houston, TX, 77030, USA. (6) Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, 1515 Holcombe Blvd, Houston, TX, 77030, USA. (7) Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, 1515 Holcombe Blvd, Houston, TX, 77030, USA. (8) Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, 1515 Holcombe Blvd, Houston, TX, 77030, USA. (9) Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, 1515 Holcombe Blvd, Houston, TX, 77030, USA. (10) Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, 1515 Holcombe Blvd, Houston, TX, 77030, USA. (11) Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, 1515 Holcombe Blvd, Houston, TX, 77030, USA. (12) Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, 1515 Holcombe Blvd, Houston, TX, 77030, USA. (13) Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, 1515 Holcombe Blvd, Houston, TX, 77030, USA. (14) Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, 1515 Holcombe Blvd, Houston, TX, 77030, USA. (15) Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, 1515 Holcombe Blvd, Houston, TX, 77030, USA. (16) Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, 1515 Holcombe Blvd, Houston, TX, 77030, USA. (17) Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, 1515 Holcombe Blvd, Houston, TX, 77030, USA. (18) Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, 1515 Holcombe Blvd, Houston, TX, 77030, USA. (19) Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, 1515 Holcombe Blvd, Houston, TX, 77030, USA. (20) Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, 1515 Holcombe Blvd, Houston, TX, 77030, USA. (21) Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, 1515 Holcombe Blvd, Houston, TX, 77030, USA. (22) Genentech, Inc 1 DNA Way, San Francisco, CA, 94080, USA. (23) Genentech, Inc 1 DNA Way, San Francisco, CA, 94080, USA. (24) Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, 1515 Holcombe Blvd, Houston, TX, 77030, USA. (25) Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, 1515 Holcombe Blvd, Houston, TX, 77030, USA. (26) Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, 1515 Holcombe Blvd, Houston, TX, 77030, USA. john.degroot@ucsf.edu.

Author Info: (1) National Key Laboratory of Immune Response and Immunotherapy, Department of General Surgery, The First Affiliated Hospital of University of Science and Technology of China, Cen

Author Info: (1) National Key Laboratory of Immune Response and Immunotherapy, Department of General Surgery, The First Affiliated Hospital of University of Science and Technology of China, Center for Advanced Interdisciplinary Science & Biomedicine IHM, Division of Life Sciences & Medicine, University of Science and Technology of China, Hefei, China. Key Laboratory of Anhui Province for Emerging and Reemerging Infectious Diseases, Hefei, China. (2) Key Laboratory of Anhui Province for Emerging and Reemerging Infectious Diseases, Hefei, China. Department of Radiology, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China. (3) National Key Laboratory of Immune Response and Immunotherapy, Department of General Surgery, The First Affiliated Hospital of University of Science and Technology of China, Center for Advanced Interdisciplinary Science & Biomedicine IHM, Division of Life Sciences & Medicine, University of Science and Technology of China, Hefei, China. Key Laboratory of Anhui Province for Emerging and Reemerging Infectious Diseases, Hefei, China. (4) National Key Laboratory of Immune Response and Immunotherapy, Department of General Surgery, The First Affiliated Hospital of University of Science and Technology of China, Center for Advanced Interdisciplinary Science & Biomedicine IHM, Division of Life Sciences & Medicine, University of Science and Technology of China, Hefei, China. Key Laboratory of Anhui Province for Emerging and Reemerging Infectious Diseases, Hefei, China. (5) National Key Laboratory of Immune Response and Immunotherapy, Department of General Surgery, The First Affiliated Hospital of University of Science and Technology of China, Center for Advanced Interdisciplinary Science & Biomedicine IHM, Division of Life Sciences & Medicine, University of Science and Technology of China, Hefei, China. Key Laboratory of Anhui Province for Emerging and Reemerging Infectious Diseases, Hefei, China. (6) National Key Laboratory of Immune Response and Immunotherapy, Department of General Surgery, The First Affiliated Hospital of University of Science and Technology of China, Center for Advanced Interdisciplinary Science & Biomedicine IHM, Division of Life Sciences & Medicine, University of Science and Technology of China, Hefei, China. Key Laboratory of Anhui Province for Emerging and Reemerging Infectious Diseases, Hefei, China. (7) National Key Laboratory of Immune Response and Immunotherapy, Department of General Surgery, The First Affiliated Hospital of University of Science and Technology of China, Center for Advanced Interdisciplinary Science & Biomedicine IHM, Division of Life Sciences & Medicine, University of Science and Technology of China, Hefei, China. Key Laboratory of Anhui Province for Emerging and Reemerging Infectious Diseases, Hefei, China. (8) Key Laboratory of Anhui Province for Emerging and Reemerging Infectious Diseases, Hefei, China. (9) National Key Laboratory of Immune Response and Immunotherapy, Department of General Surgery, The First Affiliated Hospital of University of Science and Technology of China, Center for Advanced Interdisciplinary Science & Biomedicine IHM, Division of Life Sciences & Medicine, University of Science and Technology of China, Hefei, China. Key Laboratory of Anhui Province for Emerging and Reemerging Infectious Diseases, Hefei, China. (10) The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China. (11) The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China. (12) Key Laboratory of Anhui Province for Emerging and Reemerging Infectious Diseases, Hefei, China. (13) The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China. (14) Key Laboratory of Anhui Province for Emerging and Reemerging Infectious Diseases, Hefei, China. Department of Radiology, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China. (15) National Key Laboratory of Immune Response and Immunotherapy, Department of General Surgery, The First Affiliated Hospital of University of Science and Technology of China, Center for Advanced Interdisciplinary Science & Biomedicine IHM, Division of Life Sciences & Medicine, University of Science and Technology of China, Hefei, China. Key Laboratory of Anhui Province for Emerging and Reemerging Infectious Diseases, Hefei, China. (16) Key Laboratory of Anhui Province for Emerging and Reemerging Infectious Diseases, Hefei, China. Department of Radiology, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China. (17) National Key Laboratory of Immune Response and Immunotherapy, Department of General Surgery, The First Affiliated Hospital of University of Science and Technology of China, Center for Advanced Interdisciplinary Science & Biomedicine IHM, Division of Life Sciences & Medicine, University of Science and Technology of China, Hefei, China. Key Laboratory of Anhui Province for Emerging and Reemerging Infectious Diseases, Hefei, China.

Author Info: (1) Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania. Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, Pennsylvania.

Author Info: (1) Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania. Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, Pennsylvania. (2) Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, Pennsylvania. Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. (3) Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, Pennsylvania. Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. (4) Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, Pennsylvania. Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. (5) Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, Pennsylvania. (6) Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, Pennsylvania. Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. (7) Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, Pennsylvania. Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. (8) Tmunity Therapeutics/Kite Pharma, Philadelphia, Pennsylvania. (9) Tmunity Therapeutics/Kite Pharma, Philadelphia, Pennsylvania. (10) Tmunity Therapeutics/Kite Pharma, Philadelphia, Pennsylvania. (11) Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, Pennsylvania. Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. (12) Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, Pennsylvania. Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Parker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia, Pennsylvania. (13) Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, Pennsylvania. Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. (14) Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania. Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, Pennsylvania.

Author Info: (1) Kumamoto University School of Medicine, Kumamoto, Japan. (2) Kumamoto University School of Medicine, Kumamoto, Japan. (3) Kumamoto University School of Medicine, Kumamoto, Japa

Author Info: (1) Kumamoto University School of Medicine, Kumamoto, Japan. (2) Kumamoto University School of Medicine, Kumamoto, Japan. (3) Kumamoto University School of Medicine, Kumamoto, Japan. (4) Kyoto University, Kyoto, Japan. (5) Kumamoto University School of Medicine, Kumamoto, Japan. (6) Kumamoto University, Kumamoto, Japan. (7) Kumamoto University, Kumamoto, Japan. (8) Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan. (9) Kumamoto University, Kumamoto, Japan.