Author Info: Guangdong Provincial Key laboratory of Colorectal and Pelvic Floor Disease, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, China Zhitong Niu, Bing Cheng,

Author Info: Guangdong Provincial Key laboratory of Colorectal and Pelvic Floor Disease, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, China Zhitong Niu, Bing Cheng, Yue Jiang, Yingzhen Weng, Qian Xiao, Chaoying Wei, Qiufeng Liu, Jinxin Chen, Xiaojian Wu & Wenyu WangGuangdong Institute of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, China Zhitong Niu, Bing Cheng, Yue Jiang, Yingzhen Weng, Qian Xiao, Chaoying Wei, Qiufeng Liu, Jinxin Chen, Xiaojian Wu & Wenyu WangBiomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, China Zhitong Niu, Bing Cheng, Yue Jiang, Yingzhen Weng, Qian Xiao, Guojie Long, Chaoying Wei, Qiufeng Liu, Jinxin Chen, Xiaofeng Wen, Yufeng Chen, Yan Huang, Weidong Pan, Xiaojian Wu & Wenyu WangDepartment of General Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, China Guojie Long, Xiaofeng Wen, Yufeng Chen, Weidong Pan & Xiaojian WuThe First Affiliated Hospital of Jinan University, Guangzhou, 510630, China Panpan WangDepartment of Pathology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, China Yan HuangState Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China Jing TanLaboratory of Cancer Epigenome, Division of Medical Sciences, National Cancer Centre Singapore, Singapore, 168583, Singapore Jing TanHainan Academy of Medical Science, Hainan Medical University, Haikou, 571199, China Jing TanPharmacy college, Jinan University, Guangzhou, 510632, China Ronghua ZhangCancer research institute, Jinan University, Guangzhou, 510632, China Ronghua ZhangGenome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Biopolis, 138672, Singapore Qiang YuDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore Qiang YuCancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, 169857, Singapore Qiang Yu

Author Info: (1) University of California, Los Angeles Los Angeles, CA United States. ROR: https://ror.org/046rm7j60 (2) University of California, Los Angeles LA, CA United States. ROR: https:/

Author Info: (1) University of California, Los Angeles Los Angeles, CA United States. ROR: https://ror.org/046rm7j60 (2) University of California, Los Angeles LA, CA United States. ROR: https://ror.org/046rm7j60 (3) University of California, Los Angeles Los Angeles, CA United States. ROR: https://ror.org/046rm7j60 (4) Gladstone Institutes San Francisco, California United States. ROR: https://ror.org/038321296 (5) Gladstone Institutes San Francisco, California United States. ROR: https://ror.org/038321296 (6) University of California, San Francisco San Francisco, CA United States. ROR: https://ror.org/043mz5j54 (7) University of California, Los Angeles Los Angeles, CA United States. ROR: https://ror.org/046rm7j60 (8) University of California, Los Angeles Los Angeles, CA United States. ROR: https://ror.org/046rm7j60 (9) University of California, Los Angeles Los Angeles, CA United States. ROR: https://ror.org/046rm7j60 (10) University of California, Los Angeles Los Angeles, CA United States. ROR: https://ror.org/046rm7j60 (11) Dana-Farber Cancer Institute Boston United States. ROR: https://ror.org/02jzgtq86 (12) Max Planck Institute of Biochemistry Martinsried Germany. ROR: https://ror.org/04py35477 (13) University of California, Los Angeles Los Angeles, CA United States. ROR: https://ror.org/046rm7j60 (14) University of California, San Francisco San Francisco, CA United States. ROR: https://ror.org/043mz5j54 (15) University of California, Los Angeles Los Angeles, CA United States. ROR: https://ror.org/046rm7j60 (16) University of California, Los Angeles Los Angeles, CA United States. ROR: https://ror.org/046rm7j60

Author Info: (1) Gladstone Institutes San Francisco, California United States. ROR: https://ror.org/038321296 (2) Gladstone Institutes San Francisco, California United States. ROR: https://ror.

Author Info: (1) Gladstone Institutes San Francisco, California United States. ROR: https://ror.org/038321296 (2) Gladstone Institutes San Francisco, California United States. ROR: https://ror.org/038321296 (3) H™pital Saint-Louis Paris France. ROR: https://ror.org/049am9t04 (4) University of California San Francisco Medical Center United States. ROR: https://ror.org/01t8svj65 (5) University of California, San Francisco San Francisco, CA United States. ROR: https://ror.org/043mz5j54 (6) University of California, San Francisco San Francisco, CA United States. ROR: https://ror.org/043mz5j54 (7) University of California, San Francisco San Francisco, CA United States. ROR: https://ror.org/043mz5j54 (8) Gladstone Institutes United States. ROR: https://ror.org/038321296 (9) University of California, San Francisco San Francisco, CA United States. ROR: https://ror.org/043mz5j54 (10) University of California, San Francisco San Francisco, CA United States. ROR: https://ror.org/043mz5j54 (11) University of California, San Francisco San Francisco, CA United States. ROR: https://ror.org/043mz5j54 (12) University of California, San Francisco San Francisco, CA United States. ROR: https://ror.org/043mz5j54 (13) UCSF San Francisco, CA United States. (14) Tango Therapeutics (United States) Boston, Massachusetts United States. ROR: https://ror.org/003x6t567 (15) University of California, San Francisco San Francisco, California United States. ROR: https://ror.org/043mz5j54 (16) University of California, San Francisco San Francisco, California United States. ROR: https://ror.org/043mz5j54 (17) University of California, San Francisco San Francisco, CA United States. ROR: https://ror.org/043mz5j54 (18) University of California, San Francisco United States. ROR: https://ror.org/043mz5j54 (19) Gladstone Institutes San Francisco, California United States. ROR: https://ror.org/038321296 (20) UCSF San Francisco, CA United States. (21) University of California, San Francisco San Francisco, CA United States. ROR: https://ror.org/043mz5j54

Author Info: (1) Zhejiang Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang Key Laboratory of Frontier Medical Research on Cancer Metabolism, and Institute of Transl

Author Info: (1) Zhejiang Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang Key Laboratory of Frontier Medical Research on Cancer Metabolism, and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China; Institute of Fundamental and Transdisciplinary Research, Zhejiang University Cancer Center, Zhejiang University, Hangzhou, Zhejiang 310029, China; The Center for Translational Research, The Second Affiliated Hospital and Institute of Translational Medicine, Zhejiang University, Hangzhou, Zhejiang 310029, China. (2) Department of Gastroenterology, Songjiang Research Institute, Shanghai Key Laboratory of Emotions and Affective Disorders, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 201600, China. Electronic address: dongguo@shsmu.edu.cn. (3) Zhejiang Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang Key Laboratory of Frontier Medical Research on Cancer Metabolism, and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China; Institute of Fundamental and Transdisciplinary Research, Zhejiang University Cancer Center, Zhejiang University, Hangzhou, Zhejiang 310029, China; The Center for Translational Research, The Second Affiliated Hospital and Institute of Translational Medicine, Zhejiang University, Hangzhou, Zhejiang 310029, China. (4) Department of General Surgery, Pancreatic Disease Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. (5) Zhejiang Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang Key Laboratory of Frontier Medical Research on Cancer Metabolism, and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China. (6) Zhejiang Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang Key Laboratory of Frontier Medical Research on Cancer Metabolism, and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China; Institute of Fundamental and Transdisciplinary Research, Zhejiang University Cancer Center, Zhejiang University, Hangzhou, Zhejiang 310029, China; The Center for Translational Research, The Second Affiliated Hospital and Institute of Translational Medicine, Zhejiang University, Hangzhou, Zhejiang 310029, China. (7) Department of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China. (8) Zhejiang Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang Key Laboratory of Frontier Medical Research on Cancer Metabolism, and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China; Institute of Fundamental and Transdisciplinary Research, Zhejiang University Cancer Center, Zhejiang University, Hangzhou, Zhejiang 310029, China; The Center for Translational Research, The Second Affiliated Hospital and Institute of Translational Medicine, Zhejiang University, Hangzhou, Zhejiang 310029, China. (9) Zhejiang Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang Key Laboratory of Frontier Medical Research on Cancer Metabolism, and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China; Institute of Fundamental and Transdisciplinary Research, Zhejiang University Cancer Center, Zhejiang University, Hangzhou, Zhejiang 310029, China; The Center for Translational Research, The Second Affiliated Hospital and Institute of Translational Medicine, Zhejiang University, Hangzhou, Zhejiang 310029, China. (10) Zhejiang Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang Key Laboratory of Frontier Medical Research on Cancer Metabolism, and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China; Institute of Fundamental and Transdisciplinary Research, Zhejiang University Cancer Center, Zhejiang University, Hangzhou, Zhejiang 310029, China; The Center for Translational Research, The Second Affiliated Hospital and Institute of Translational Medicine, Zhejiang University, Hangzhou, Zhejiang 310029, China. (11) Zhejiang Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang Key Laboratory of Frontier Medical Research on Cancer Metabolism, and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China; Institute of Fundamental and Transdisciplinary Research, Zhejiang University Cancer Center, Zhejiang University, Hangzhou, Zhejiang 310029, China; The Center for Translational Research, The Second Affiliated Hospital and Institute of Translational Medicine, Zhejiang University, Hangzhou, Zhejiang 310029, China. (12) Zhejiang Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang Key Laboratory of Frontier Medical Research on Cancer Metabolism, and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China; Institute of Fundamental and Transdisciplinary Research, Zhejiang University Cancer Center, Zhejiang University, Hangzhou, Zhejiang 310029, China; The Center for Translational Research, The Second Affiliated Hospital and Institute of Translational Medicine, Zhejiang University, Hangzhou, Zhejiang 310029, China. (13) Zhejiang Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang Key Laboratory of Frontier Medical Research on Cancer Metabolism, and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China; Institute of Fundamental and Transdisciplinary Research, Zhejiang University Cancer Center, Zhejiang University, Hangzhou, Zhejiang 310029, China; The Center for Translational Research, The Second Affiliated Hospital and Institute of Translational Medicine, Zhejiang University, Hangzhou, Zhejiang 310029, China. (14) Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Zhejiang Provincial Clinical Research Center for Cancer, Department of Medical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Cancer Center, Zhejiang University, Hangzhou, Zhejiang 310058, China. (15) Zhejiang Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang Key Laboratory of Frontier Medical Research on Cancer Metabolism, and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China; Institute of Fundamental and Transdisciplinary Research, Zhejiang University Cancer Center, Zhejiang University, Hangzhou, Zhejiang 310029, China; The Center for Translational Research, The Second Affiliated Hospital and Institute of Translational Medicine, Zhejiang University, Hangzhou, Zhejiang 310029, China. (16) Zhejiang Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang Key Laboratory of Frontier Medical Research on Cancer Metabolism, and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China. (17) Zhejiang Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang Key Laboratory of Frontier Medical Research on Cancer Metabolism, and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China; Institute of Fundamental and Transdisciplinary Research, Zhejiang University Cancer Center, Zhejiang University, Hangzhou, Zhejiang 310029, China; The Center for Translational Research, The Second Affiliated Hospital and Institute of Translational Medicine, Zhejiang University, Hangzhou, Zhejiang 310029, China. (18) Center for Regeneration and Aging Medicine, The Fourth Affiliated Hospital of School of Medicine, International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, Zhejiang 322000, China. (19) Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Zhejiang Provincial Clinical Research Center for Cancer, Department of Medical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Cancer Center, Zhejiang University, Hangzhou, Zhejiang 310058, China. (20) Zhejiang Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang Key Laboratory of Frontier Medical Research on Cancer Metabolism, and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China; Institute of Fundamental and Transdisciplinary Research, Zhejiang University Cancer Center, Zhejiang University, Hangzhou, Zhejiang 310029, China; The Center for Translational Research, The Second Affiliated Hospital and Institute of Translational Medicine, Zhejiang University, Hangzhou, Zhejiang 310029, China. (21) Department of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China. Electronic address: wam@zju.edu.cn. (22) Department of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China. Electronic address: dingyuan@zju.edu.cn. (23) Zhejiang Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang Key Laboratory of Frontier Medical Research on Cancer Metabolism, and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China; Institute of Fundamental and Transdisciplinary Research, Zhejiang University Cancer Center, Zhejiang University, Hangzhou, Zhejiang 310029, China; The Center for Translational Research, The Second Affiliated Hospital and Institute of Translational Medicine, Zhejiang University, Hangzhou, Zhejiang 310029, China. Electronic address: zhiminlu@zju.edu.cn.

Author Info: (1) Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USA; Center of Excellence for Cancer Immunology and Immunotherapy, University of Michigan Rogel

Author Info: (1) Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USA; Center of Excellence for Cancer Immunology and Immunotherapy, University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA. (2) Department of Molecular and Cellular Physiology, Albany Medical College, Albany, NY, USA. (3) Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USA; Center of Excellence for Cancer Immunology and Immunotherapy, University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA; Graduate Program in Immunology, University of Michigan, Ann Arbor, MI, USA. (4) Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USA; Center of Excellence for Cancer Immunology and Immunotherapy, University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA. (5) Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA. (6) Department of Molecular & Physiology, University of Michigan, Ann Arbor, MI, USA. (7) Program in Cellular and Molecular Medicine, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA. (8) Program in Cellular and Molecular Medicine, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA. (9) Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA. (10) Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USA; Center of Excellence for Cancer Immunology and Immunotherapy, University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA. (11) Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USA; Center of Excellence for Cancer Immunology and Immunotherapy, University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA. (12) Department of Molecular & Physiology, University of Michigan, Ann Arbor, MI, USA. (13) Department of Molecular & Physiology, University of Michigan, Ann Arbor, MI, USA. (14) Program in Cellular and Molecular Medicine, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA. (15) Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia. (16) Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USA; Center of Excellence for Cancer Immunology and Immunotherapy, University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA. (17) Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USA; Center of Excellence for Cancer Immunology and Immunotherapy, University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA. (18) Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USA; Center of Excellence for Cancer Immunology and Immunotherapy, University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA; Graduate Program in Immunology, University of Michigan, Ann Arbor, MI, USA. (19) Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USA; Center of Excellence for Cancer Immunology and Immunotherapy, University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA; Graduate Program in Immunology, University of Michigan, Ann Arbor, MI, USA. (20) Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USA. (21) Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USA. (22) Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USA. (23) Cayman Chemical, Ann Arbor, MI, USA. (24) Cayman Chemical, Ann Arbor, MI, USA. (25) Department of Molecular & Physiology, University of Michigan, Ann Arbor, MI, USA; Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA. (26) Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USA; Center of Excellence for Cancer Immunology and Immunotherapy, University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA; Graduate Program in Immunology, University of Michigan, Ann Arbor, MI, USA. Electronic address: ilonak@umich.edu. (27) Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia. (28) Department of Molecular and Cellular Physiology, Albany Medical College, Albany, NY, USA. Electronic address: barrosm@amc.edu. (29) Program in Cellular and Molecular Medicine, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA. Electronic address: judy.lieberman@childrens.harvard.edu. (30) Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USA; Center of Excellence for Cancer Immunology and Immunotherapy, University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA; Graduate Program in Immunology, University of Michigan, Ann Arbor, MI, USA. Electronic address: wzou@umich.edu.

Author Info: (1) The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, China. (2) T

Author Info: (1) The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, China. (2) The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, China. (3) The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, China. (4) The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, China. Department of Hepatopancreatobiliary Surgery, First Affiliated Hospital of Fujian Medical University, Fuzhou, China. (5) Fujian Key Laboratory of Integrative Medicine on Geriatrics, Fujian University of Traditional Chinese Medicine, Fuzhou, China. (6) The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, China. (7) The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, China. (8) The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, China. (9) The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, China. (10) The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, China. (11) The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, China. (12) The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, China. (13) The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, China. (14) The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, China. (15) The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, China. (16) The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, China. (17) The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, China xiaoloong.liu@gmail.com lamp197311@126.com caizhixiong1985@163.com. (18) The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, China xiaoloong.liu@gmail.com lamp197311@126.com caizhixiong1985@163.com. Department of Hepatopancreatobiliary Surgery, First Affiliated Hospital of Fujian Medical University, Fuzhou, China. (19) The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, China xiaoloong.liu@gmail.com lamp197311@126.com caizhixiong1985@163.com.

Author Info: (1) Engineering Research Center of Molecular & Neuroimaging, Ministry of Education, School of Life Science and Technology, Xidian University, Xi'an 710126, P.R. China. (2) Engineer

Author Info: (1) Engineering Research Center of Molecular & Neuroimaging, Ministry of Education, School of Life Science and Technology, Xidian University, Xi'an 710126, P.R. China. (2) Engineering Research Center of Molecular & Neuroimaging, Ministry of Education, School of Life Science and Technology, Xidian University, Xi'an 710126, P.R. China. Electronic address: chenyang@xidian.edu.cn. (3) Engineering Research Center of Molecular & Neuroimaging, Ministry of Education, School of Life Science and Technology, Xidian University, Xi'an 710126, P.R. China. (4) Engineering Research Center of Molecular & Neuroimaging, Ministry of Education, School of Life Science and Technology, Xidian University, Xi'an 710126, P.R. China. (5) Engineering Research Center of Molecular & Neuroimaging, Ministry of Education, School of Life Science and Technology, Xidian University, Xi'an 710126, P.R. China. (6) Engineering Research Center of Molecular & Neuroimaging, Ministry of Education, School of Life Science and Technology, Xidian University, Xi'an 710126, P.R. China. (7) Engineering Research Center of Molecular & Neuroimaging, Ministry of Education, School of Life Science and Technology, Xidian University, Xi'an 710126, P.R. China. (8) Engineering Research Center of Molecular & Neuroimaging, Ministry of Education, School of Life Science and Technology, Xidian University, Xi'an 710126, P.R. China. (9) Engineering Research Center of Molecular & Neuroimaging, Ministry of Education, School of Life Science and Technology, Xidian University, Xi'an 710126, P.R. China. Electronic address: chenzhuang@xidian.edu.cn. (10) Research Center of Nano Technology and Application Engineering, The First Dongguan Affiliated Hospital, School of Pharmacy, Guangdong Medical University, Dongguan 523808, P.R. China. Electronic address: wsyt132@163.com. (11) Engineering Research Center of Molecular & Neuroimaging, Ministry of Education, School of Life Science and Technology, Xidian University, Xi'an 710126, P.R. China. Electronic address: qiaochaoqiang@xidian.edu.cn. (12) Engineering Research Center of Molecular & Neuroimaging, Ministry of Education, School of Life Science and Technology, Xidian University, Xi'an 710126, P.R. China. Electronic address: wangzl@xidian.edu.cn.

Author Info: (1) Chongqing Key Laboratory of Gene and Cell Therapy, Chongqing 400039, China; Chongqing Precision Biotech Co., Ltd., Chongqing 400039, China. Electronic address: yangzhi@precisio

Author Info: (1) Chongqing Key Laboratory of Gene and Cell Therapy, Chongqing 400039, China; Chongqing Precision Biotech Co., Ltd., Chongqing 400039, China. Electronic address: yangzhi@precision-biotech.com. (2) 920th Hospital of Joint Logistics Support Force of People's Liberationsi Army of China, Kunming 650100, Yunnan, China. (3) Chongqing Key Laboratory of Gene and Cell Therapy, Chongqing 400039, China; Chongqing Precision Biotech Co., Ltd., Chongqing 400039, China. (4) Chongqing Key Laboratory of Gene and Cell Therapy, Chongqing 400039, China; Chongqing Precision Biotech Co., Ltd., Chongqing 400039, China. (5) Chongqing Key Laboratory of Gene and Cell Therapy, Chongqing 400039, China; Chongqing Precision Biotech Co., Ltd., Chongqing 400039, China. (6) 920th Hospital of Joint Logistics Support Force of People's Liberationsi Army of China, Kunming 650100, Yunnan, China. (7) 920th Hospital of Joint Logistics Support Force of People's Liberationsi Army of China, Kunming 650100, Yunnan, China. (8) 920th Hospital of Joint Logistics Support Force of People's Liberationsi Army of China, Kunming 650100, Yunnan, China. (9) Chongqing Key Laboratory of Gene and Cell Therapy, Chongqing 400039, China; Chongqing Precision Biotech Co., Ltd., Chongqing 400039, China. (10) 920th Hospital of Joint Logistics Support Force of People's Liberationsi Army of China, Kunming 650100, Yunnan, China. (11) 920th Hospital of Joint Logistics Support Force of People's Liberationsi Army of China, Kunming 650100, Yunnan, China. (12) Chongqing Key Laboratory of Gene and Cell Therapy, Chongqing 400039, China; Chongqing Precision Biotech Co., Ltd., Chongqing 400039, China. (13) Chongqing Key Laboratory of Gene and Cell Therapy, Chongqing 400039, China; Chongqing Precision Biotech Co., Ltd., Chongqing 400039, China. (14) Chongqing Key Laboratory of Gene and Cell Therapy, Chongqing 400039, China; Chongqing Precision Biotech Co., Ltd., Chongqing 400039, China. (15) Chongqing Key Laboratory of Gene and Cell Therapy, Chongqing 400039, China; Chongqing Precision Biotech Co., Ltd., Chongqing 400039, China. (16) Chongqing Key Laboratory of Gene and Cell Therapy, Chongqing 400039, China; Chongqing Precision Biotech Co., Ltd., Chongqing 400039, China. (17) 920th Hospital of Joint Logistics Support Force of People's Liberationsi Army of China, Kunming 650100, Yunnan, China. (18) 920th Hospital of Joint Logistics Support Force of People's Liberationsi Army of China, Kunming 650100, Yunnan, China. (19) 920th Hospital of Joint Logistics Support Force of People's Liberationsi Army of China, Kunming 650100, Yunnan, China. Electronic address: sanbin1011@163.com. (20) Chongqing Key Laboratory of Gene and Cell Therapy, Chongqing 400039, China; Chongqing Precision Biotech Co., Ltd., Chongqing 400039, China. Electronic address: cqian8634@gmail.com.

Author Info: (1) Department of Thoracic Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong Key Laboratory of Targeted Drug Delivery and Advanced Pharmaceutics, NMPA Key Laboratory fo

Author Info: (1) Department of Thoracic Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong Key Laboratory of Targeted Drug Delivery and Advanced Pharmaceutics, NMPA Key Laboratory for Technology Research and Evaluation of Drug Products and Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China.(2) Shandong University of Traditional Chinese Medicine, Jinan, China. (3) Department of Neurosurgery, Qilu Hospital and Institute of Brain and Brain-Inspired Science, Cheeloo College of Medicine, Shandong University, Jinan, China. (4)These authors contributed equally: Chunwei Tang, Weiyi Sun, Zhenmei Yang. e-mail: xinyijiang@sdu.edu.cn; chenchen27@sdu.edu.cn; wxzbc@mail.sdu.edu.cn; kzhao2013@sdu.edu.cn; jyhantw@email.sdu.edu.cn

Author Info: (1) Broad Institute of MIT and Harvard, Cambridge, MA, United States. (2) Broad Institute of MIT and Harvard, Cambridge, MA, United States. Department of Molecular Biology, Massach

Author Info: (1) Broad Institute of MIT and Harvard, Cambridge, MA, United States. (2) Broad Institute of MIT and Harvard, Cambridge, MA, United States. Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States. (3) Broad Institute of MIT and Harvard, Cambridge, MA, United States. (4) Broad Institute of MIT and Harvard, Cambridge, MA, United States. (5) Broad Institute of MIT and Harvard, Cambridge, MA, United States. (6) Broad Institute of MIT and Harvard, Cambridge, MA, United States. Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States. (7) Broad Institute of MIT and Harvard, Cambridge, MA, United States. (8) Broad Institute of MIT and Harvard, Cambridge, MA, United States. Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States. (9) Broad Institute of MIT and Harvard, Cambridge, MA, United States. Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, United States. (10) Broad Institute of MIT and Harvard, Cambridge, MA, United States. Massachusetts Institute of Technology, Cambridge, MA, United States. (11) Broad Institute of MIT and Harvard, Cambridge, MA, United States. Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States. Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, United States. Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, MA, United States.