Weekly Digests

2025

July

CD8s get by without a little help from their friends

July 2, 2025

During acute infections, the primary immune response depends on CD4+ T cells providing help to CD8+ T cells. However, many effector CD8+ T cells (Teff) can respond to pathogens independently of helper responses, but these cells respond poorly to pathogen rechallenge. Van der Heide et al. investigated this helpless CD8+ T memory (Tmem)...

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