While most cancer immunotherapy research focuses on adaptive immunity, Demaria et al. reviewed the role of innate immunity. They described stimulators of innate immune reactions (microbial products, stressors, chemotherapeutics), as well as strategies that improve the innate immune system’s ability to initiate adaptive immunity, that enhance the antitumor effector functions of innate immune cells, and that minimize immunosuppressive functions of some innate immune cells. They also discussed the importance of exploring how therapies targeting adaptive immunity may impact or be impacted by the innate immune system.
New therapies that promote antitumour immunity have been recently developed. Most of these immunomodulatory approaches have focused on enhancing T-cell responses, either by targeting inhibitory pathways with immune checkpoint inhibitors, or by targeting activating pathways, as with chimeric antigen receptor T cells or bispecific antibodies. Although these therapies have led to unprecedented successes, only a minority of patients with cancer benefit from these treatments, highlighting the need to identify new cells and molecules that could be exploited in the next generation of immunotherapy. Given the crucial role of innate immune responses in immunity, harnessing these responses opens up new possibilities for long-lasting, multilayered tumour control.
Author Info: (1) Innate Pharma, Marseille, France. (2) Innate Pharma, Marseille, France. (3) Aix Marseille Universite, INSERM, CNRS, Centre d'Immunologie de Marseille-Luminy, Marseille, France.
Author Info: (1) Innate Pharma, Marseille, France. (2) Innate Pharma, Marseille, France. (3) Aix Marseille Universite, INSERM, CNRS, Centre d'Immunologie de Marseille-Luminy, Marseille, France. Institut Pasteur, Paris, France. (4) Innate Pharma, Marseille, France. (5) Howard Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA. (6) Innate Pharma, Marseille, France. vivier@ciml.univ-mrs.fr. Aix Marseille Universite, INSERM, CNRS, Centre d'Immunologie de Marseille-Luminy, Marseille, France. vivier@ciml.univ-mrs.fr. Service d'Immunologie, Marseille Immunopole, Hopital de la Timone, Assistance Publique-Hopitaux de Marseille, Marseille, France. vivier@ciml.univ-mrs.fr.
