(1) Molfetta R (2) Zitti B (3) Lecce M (4) Milito ND (5) Stabile H (6) Fionda C (7) Cippitelli M (8) Gismondi A (9) Santoni A (10) Paolini R

International journal of molecular sciences | Free PMC Article

CD155 is an adhesion molecule belonging to the Nectin/Nectin-like family often overexpressed on tumor cells and involved in many different processes such as cell adhesion, migration and proliferation. In contrast to these pro-tumorigenic functions, CD155 is also a ligand for the activating receptor DNAM-1 expressed on cytotoxic lymphocytes including Natural Killer (NK) cells and involved in anti-tumor immune response. However, during tumor progression inhibitory receptors for CD155 are up-regulated on the surface of effector cells, contributing to an impairment of their cytotoxic capacity. In this review we will focus on the roles of CD155 as a ligand for the activating receptor DNAM-1 regulating immune surveillance against cancer and as pro-oncogenic molecule favoring tumor proliferation, invasion and immune evasion. A deeper understanding of the multiple roles played by CD155 in cancer development contributes to improving anti-tumor strategies aimed to potentiate immune response against cancer.

Author Info: (1) Department of Molecular Medicine, "Sapienza" University of Rome, Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, "Viale Regina Elena 291, 00161 Ro

Author Info: (1) Department of Molecular Medicine, "Sapienza" University of Rome, Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, "Viale Regina Elena 291, 00161 Rome, Italy. (2) Department of Molecular Medicine, "Sapienza" University of Rome, Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, "Viale Regina Elena 291, 00161 Rome, Italy. (3) Department of Molecular Medicine, "Sapienza" University of Rome, Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, "Viale Regina Elena 291, 00161 Rome, Italy. (4) Department of Molecular Medicine, "Sapienza" University of Rome, Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, "Viale Regina Elena 291, 00161 Rome, Italy. (5) Department of Molecular Medicine, "Sapienza" University of Rome, Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, "Viale Regina Elena 291, 00161 Rome, Italy. (6) Department of Molecular Medicine, "Sapienza" University of Rome, Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, "Viale Regina Elena 291, 00161 Rome, Italy. (7) Department of Molecular Medicine, "Sapienza" University of Rome, Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, "Viale Regina Elena 291, 00161 Rome, Italy. (8) Department of Molecular Medicine, "Sapienza" University of Rome, Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, "Viale Regina Elena 291, 00161 Rome, Italy. (9) Department of Molecular Medicine, "Sapienza" University of Rome, Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, "Viale Regina Elena 291, 00161 Rome, Italy. (10) Department of Molecular Medicine, "Sapienza" University of Rome, Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, "Viale Regina Elena 291, 00161 Rome, Italy.

Citation: Int J Mol Sci 2020 Jan 30 21: Epub01/30/2020

Link to PUBMED: http://www.ncbi.nlm.nih.gov/pubmed/32019260

Tags: