2025
August
Lymph node T cells lead the antitumor charge, while tumor-resident T cells fall short
August 13, 2025
While CD8+ T cells with various stemness, tissue residency, and exhaustion features have been implicated in antitumor responses and ICB efficacy, the exact contribution of each subset remains poorly understood. Wijesinghe, Rausch, et al. used multiple genetic murine models to investigate the functionality and relation to ICB efficacy of various T cell subsets...
Novel binder designs mimic TCR specificity for pMCH-I
August 6, 2025
T cell receptors (TCRs) are highly specific for peptide–MHC (pMHC) complexes, allowing for recognition of specific intracellular antigens, and making them extremely useful in targeting specific target cells. However, TCRs that target specific pMHCs are often difficult to identify. In lieu of identifying TCRs, Liu, Greenwood, Bonzanini, et al. set out to identify...
