Author Info: (1) CEA Fontenay-aux-Roses Paris France. ROR: https://ror.org/010j2gw05 (2) H™pital Saint-Louis Paris France. ROR: https://ror.org/049am9t04 (3) CEA Grenoble Grenoble France. ROR:

Author Info: (1) CEA Fontenay-aux-Roses Paris France. ROR: https://ror.org/010j2gw05 (2) H™pital Saint-Louis Paris France. ROR: https://ror.org/049am9t04 (3) CEA Grenoble Grenoble France. ROR: https://ror.org/02mg6n827 (4) CEA Fontenay-aux-Roses Paris France. ROR: https://ror.org/010j2gw05 (5) Inserm Paris France. ROR: https://ror.org/02vjkv261 (6) Inserm Paris France. ROR: https://ror.org/02vjkv261 (7) CEA Fontenay-aux-Roses Paris France. ROR: https://ror.org/010j2gw05 (8) APHP Paris France. (9) H™pital Saint-Louis, Assistance publique H™pitaux de Paris Paris France. (10) APHP Paris France. (11) Assistance Publique - H™pitaux de Paris Paris France. ROR: https://ror.org/00pg5jh14 (12) CEA Paris-Saclay - Etablissement de Fontenay-aux-roses Paris France. (13) Commissariat ˆ l'Energie Atomique et aux Energies Alternatives Paris France. (14) AP-HP, H™pital Saint-Louis Paris France. (15) Commissariat a l'Energie Atomique et aux Energies Alternatives (CEA) Grenoble France. (16) Inserm Paris France. ROR: https://ror.org/02vjkv261 (17) CEA Fontenay-aux-Roses Paris France. ROR: https://ror.org/010j2gw05 (18) Atomic Energy and Alternative Energies Commission Paris France. ROR: https://ror.org/00jjx8s55

Author Info: (1) Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia. Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC, Austra

Author Info: (1) Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia. Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia. (2) Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia. Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia. (3) Bioinformatics, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia. (4) Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia. Bioinformatics, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia. (5) Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia. Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia. (6) Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia. (7) Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia. (8) Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia. (9) Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia. (10) Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia. (11) Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia. (12) Roche Innovation Center, Zurich, Switzerland. (13) Roche Innovation Center Basel, Roche Pharma Research and Early Development, Basel, Switzerland. (14) Roche Innovation Center Basel, Roche Pharma Research and Early Development, Basel, Switzerland. (15) Department of Dermatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland. (16) Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia. Melanoma Research Victoria, Melbourne, VIC, Australia. Division of Research, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia. (17) Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia. Melanoma Research Victoria, Melbourne, VIC, Australia. Division of Research, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia. (18) Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia. Melanoma Research Victoria, Melbourne, VIC, Australia. Division of Research, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia. (19) Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia. (20) Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia. Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia. (21) Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia. Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia. (22) Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia. Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia. (23) Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia. Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia. (24) Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia. Division of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia. (25) Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia. Melanoma Research Victoria, Melbourne, VIC, Australia. Division of Research, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia. Cancer Biology and Therapeutics Program, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia. (26) Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia. (27) Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia. paul.neeson@petermac.org. Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia. paul.neeson@petermac.org.

Author Info: (1) Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: guanglei_csu@163.com. (2) Departme

Author Info: (1) Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: guanglei_csu@163.com. (2) Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. (3) Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. (4) Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. (5) Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. (6) Department of Molecular and Cellular Oncology, Division of Basic Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. (7) Metabolomics Core Facility, Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. (8) Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. (9) Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. (10) Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. (11) Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. (12) Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. (13) Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. (14) Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. (15) Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. (16) Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. (17) Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. (18) Department of Biostatistics, Division of Discovery Science, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. (19) Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. (20) Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. (21) Department of Molecular and Cellular Oncology, Division of Basic Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. (22) Department of Thoracic/Head and Neck Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. (23) Department of Thoracic/Head and Neck Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. (24) Department of Thoracic/Head and Neck Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. (25) Department of Biostatistics, Division of Discovery Science, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. (26) Department of Thoracic/Head and Neck Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. (27) Department of Thoracic and Cardiovascular Surgery, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. (28) Department of Thoracic/Head and Neck Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. (29) Department of Molecular and Cellular Oncology, Division of Basic Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. (30) Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. (31) Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX 77030, USA. (32) Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. (33) Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. (34) Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. (35) Department of Biostatistics, Division of Discovery Science, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. (36) Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX 77030, USA. Electronic address: bgan@mdanderson.org.

Author Info: (1) Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden. (2) Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Sto

Author Info: (1) Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden. (2) Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden. (3) Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden. (4) Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden. (5) Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden. (6) Department of Gastroenterology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. (7) Laboratory of Molecular Genetics and Immunology, Rockefeller University, New York, NY, USA. (8) University of Munster, Institute of Experimental Pathology, Munster, Germany. (9) Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden. Electronic address: mikael.karlsson@ki.se.

Author Info: (1) Division of Experimental Neurosurgery, Department of Neurosurgery, Heidelberg University Hospital, Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany; Divis

Author Info: (1) Division of Experimental Neurosurgery, Department of Neurosurgery, Heidelberg University Hospital, Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany; Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address: lena.jassowicz@med.uni-heidelberg.de. (2) Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany. (3) Division of Experimental Neurosurgery, Department of Neurosurgery, Heidelberg University Hospital, Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany. (4) Department of Biostatistics, Oslo Centre for Biostatistics and Epidemiology, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway. (5) Division of Experimental Neurosurgery, Department of Neurosurgery, Heidelberg University Hospital, Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany. (6) Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany. (7) Division of Experimental Neurosurgery, Department of Neurosurgery, Heidelberg University Hospital, Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany. (8) Division of Experimental Neurosurgery, Department of Neurosurgery, Heidelberg University Hospital, Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany. (9) Division of Experimental Neurosurgery, Department of Neurosurgery, Heidelberg University Hospital, Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany. (10) Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany. (11) Division of Experimental Neurosurgery, Department of Neurosurgery, Heidelberg University Hospital, Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany; Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany. (12) Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany. (13) Division of Experimental Neurosurgery, Department of Neurosurgery, Heidelberg University Hospital, Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany; Department of Neurosurgery, Heidelberg University Hospital, Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany. (14) Division Immune Regulation in Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany. (15) Division of Molecular and Translational Radiation Oncology and Clinical Cooperation Unit Translational Radiation Oncology, German Cancer Research Center (DKFZ) and Heidelberg University Hospital, Heidelberg, Germany. (16) Division of Molecular and Translational Radiation Oncology and Clinical Cooperation Unit Translational Radiation Oncology, German Cancer Research Center (DKFZ) and Heidelberg University Hospital, Heidelberg, Germany. (17) Division of Chromatin Networks, German Cancer Research Center (DKFZ) and Bioquant, Heidelberg, Germany. (18) Division of Experimental Neurosurgery, Department of Neurosurgery, Heidelberg University Hospital, Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany; Department of Neurosurgery, Heidelberg University Hospital, Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany. (19) Division of Experimental Neurosurgery, Department of Neurosurgery, Heidelberg University Hospital, Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany; Department of Neurosurgery, Heidelberg University Hospital, Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany. (20) Division of Experimental Neurosurgery, Department of Neurosurgery, Heidelberg University Hospital, Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany; Department of Neurosurgery, Heidelberg University Hospital, Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany. (21) Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), and Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany. (22) Hamamatsu Tissue Imaging and Analysis Center, BioQuant, University of Heidelberg, Heidelberg, Germany. (23) Division of Experimental Neurosurgery, Department of Neurosurgery, Heidelberg University Hospital, Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany. (24) Division of Experimental Neurosurgery, Department of Neurosurgery, Heidelberg University Hospital, Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany. (25) Division of Experimental Neurosurgery, Department of Neurosurgery, Heidelberg University Hospital, Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany. (26) Department of Biostatistics, Oslo Centre for Biostatistics and Epidemiology, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway; Oslo Centre for Biostatistics and Epidemiology, Research Support Services, Oslo University Hospital, Oslo, Norway. (27) Single Cell Open Lab, German Cancer Research Center (DKFZ), Heidelberg, Germany. (28) Single Cell Open Lab, German Cancer Research Center (DKFZ), Heidelberg, Germany. (29) National Center for Tumor Diseases (NCT), NCT Heidelberg, a Partnership Between the German Cancer Research Center (DKFZ), the University Hospital Heidelberg (UKHD), The Heidelberg Medical Faculty of the Heidelberg University, and the Thorax Clinic Heidelberg, Heidelberg, Germany. (30) Department of Medical Oncology, Heidelberg University Hospital, Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany. (31) National Center for Tumor Diseases (NCT), NCT Heidelberg, a Partnership Between the German Cancer Research Center (DKFZ), the University Hospital Heidelberg (UKHD), The Heidelberg Medical Faculty of the Heidelberg University, and the Thorax Clinic Heidelberg, Heidelberg, Germany. (32) National Center for Tumor Diseases (NCT), NCT Heidelberg, a Partnership Between the German Cancer Research Center (DKFZ), the University Hospital Heidelberg (UKHD), The Heidelberg Medical Faculty of the Heidelberg University, and the Thorax Clinic Heidelberg, Heidelberg, Germany; Department of Medical Oncology, Heidelberg University Hospital, Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany; Department of Gynecology and Obstetrics, Heidelberg University Hospital, Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany. (33) Division Immune Regulation in Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany. (34) Division of Chromatin Networks, German Cancer Research Center (DKFZ) and Bioquant, Heidelberg, Germany. (35) Division of Molecular and Translational Radiation Oncology and Clinical Cooperation Unit Translational Radiation Oncology, German Cancer Research Center (DKFZ) and Heidelberg University Hospital, Heidelberg, Germany. (36) Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany. (37) Department of Neurosurgery, Heidelberg University Hospital, Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany. (38) Department of Neurosurgery, Heidelberg University Hospital, Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany. (39) Single Cell Open Lab, German Cancer Research Center (DKFZ), Heidelberg, Germany. (40) Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany; National Center for Tumor Diseases (NCT), NCT Heidelberg, a Partnership Between the German Cancer Research Center (DKFZ), the University Hospital Heidelberg (UKHD), The Heidelberg Medical Faculty of the Heidelberg University, and the Thorax Clinic Heidelberg, Heidelberg, Germany. (41) Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany. (42) Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address: m.seiffert@dkfz-heidelberg.de. (43) Division of Experimental Neurosurgery, Department of Neurosurgery, Heidelberg University Hospital, Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany. Electronic address: h.mende@med.uni-heidelberg.de.

Author Info: (1) Department of Biomedicine, University Hospital and University of Basel, Basel, Switzerland. (2) Aix Marseille UniversitŽ, CNRS, INSERM, Centre d'Immunologie de Marseille-Luminy

Author Info: (1) Department of Biomedicine, University Hospital and University of Basel, Basel, Switzerland. (2) Aix Marseille UniversitŽ, CNRS, INSERM, Centre d'Immunologie de Marseille-Luminy, Marseille, France. (3) Department of Biomedicine, University Hospital and University of Basel, Basel, Switzerland. (4) Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany. (5) Department of Biomedicine, University Hospital and University of Basel, Basel, Switzerland. (6) Department of Biomedicine, University Hospital and University of Basel, Basel, Switzerland. (7) Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany. (8) Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany. (9) Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany. (10) Department of Biomedicine, University Hospital and University of Basel, Basel, Switzerland. (11) Department of Biomedicine, University Hospital and University of Basel, Basel, Switzerland. (12) Institute of Pathology, University Hospital and University of Basel, Basel, Switzerland. (13) Department of Biomedicine, University Hospital and University of Basel, Basel, Switzerland. (14) Department of Biomedicine, University Hospital and University of Basel, Basel, Switzerland. (15) Department of Biomedicine, University Hospital and University of Basel, Basel, Switzerland. Roche Pharma Research and Early Development pRED, Roche Innovation Center, Basel, Switzerland. (16) Department of Biomedicine, University Hospital and University of Basel, Basel, Switzerland. (17) Department of Thoracic Surgery, University Hospital Basel, Basel, Switzerland. (18) Department of Thoracic Surgery, University Hospital Basel, Basel, Switzerland. (19) German Centre for Lung Diseases (DZL), BREATH site, Hannover, Germany. Institute of Pathology, Hannover Medical School, Hannover, Germany. (20) Department of Biomedicine, University Hospital and University of Basel, Basel, Switzerland. Medical Oncology, University Hospital Basel, Basel, Switzerland. (21) Institute of Pathology, University Hospital and University of Basel, Basel, Switzerland. (22) Department of Biomedicine, University Hospital and University of Basel, Basel, Switzerland. (23) Department of Biomedicine, University Hospital and University of Basel, Basel, Switzerland. (24) Department of Biomedicine, University Hospital and University of Basel, Basel, Switzerland. (25) Institute of Pathology, University Hospital and University of Basel, Basel, Switzerland. (26) Department of Biomedicine, University Hospital and University of Basel, Basel, Switzerland. Medical Oncology, University Hospital Basel, Basel, Switzerland. (27) Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany. German Centre for Lung Diseases (DZL), BREATH site, Hannover, Germany. German Centre for Infection Research (DZIF), TTU-IICH, Hannover/Braunschweig site, Hannover, Germany. (28) Department of Biomedicine, University Hospital and University of Basel, Basel, Switzerland. (29) Aix Marseille UniversitŽ, CNRS, INSERM, Centre d'Immunologie de Marseille-Luminy, Marseille, France. APHM, H™pital de la Timone, Marseille-Immunop™le Profiling Platform, Marseille, France. Paris-Saclay Cancer Cluster, Villejuif, France. Ecole Polytechnique, Palaiseau, France. (30) Roche Pharma Research and Early Development pRED, Roche Innovation Center, Basel, Switzerland. (31) Department of Biomedicine, University Hospital and University of Basel, Basel, Switzerland. Medical Oncology, University Hospital Basel, Basel, Switzerland.

Author Info: (1) Lab of Dendritic Cell Biology and Cancer Immunotherapy, VIB Center for Inflammation Research, Brussels, Belgium. Lab of Cellular and Molecular Immunology, Brussels Center for I

Author Info: (1) Lab of Dendritic Cell Biology and Cancer Immunotherapy, VIB Center for Inflammation Research, Brussels, Belgium. Lab of Cellular and Molecular Immunology, Brussels Center for Immunology, Vrije Universiteit Brussel, Brussels, Belgium. Lab of Tumor Immunology and Immunotherapy, Department of Oncology, Leuven Cancer Institute, KU Leuven, Leuven, Belgium. (2) Lab of Dendritic Cell Biology and Cancer Immunotherapy, VIB Center for Inflammation Research, Brussels, Belgium. Lab of Cellular and Molecular Immunology, Brussels Center for Immunology, Vrije Universiteit Brussel, Brussels, Belgium. (3) Lab of Dendritic Cell Biology and Cancer Immunotherapy, VIB Center for Inflammation Research, Brussels, Belgium. Lab of Cellular and Molecular Immunology, Brussels Center for Immunology, Vrije Universiteit Brussel, Brussels, Belgium. (4) Laboratory for Translational Genetics, Department of Human Genetics, KU Leuven, Leuven, Belgium. Laboratory for Translational Genetics, VIB Center for Cancer Biology, Leuven, Belgium. (5) Laboratory for ER Stress and Inflammation, VIB Center for Inflammation Research, Ghent, Belgium. Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium. Laboratory for Barriers in Inflammation, VIB Center for Inflammation Research, Ghent, Belgium. Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium. (6) Lab of Dendritic Cell Biology and Cancer Immunotherapy, VIB Center for Inflammation Research, Brussels, Belgium. Lab of Cellular and Molecular Immunology, Brussels Center for Immunology, Vrije Universiteit Brussel, Brussels, Belgium. (7) Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium. VIB Single Cell Core; VIB, Ghent-Leuven, Belgium. (8) Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Swiss Federal Institute of Technology in Lausanne (EPFL), Lausanne, Switzerland. Agora Cancer Research Center, Lausanne, Switzerland. (9) Laboratory of Cancer Signaling, GIGA-Institute, University of Lige, Lige, Belgium. (10) Laboratory of Cancer Signaling, GIGA-Institute, University of Lige, Lige, Belgium. (11) Lab of Cellular and Molecular Immunology, Brussels Center for Immunology, Vrije Universiteit Brussel, Brussels, Belgium. (12) Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium. VIB Single Cell Core; VIB, Ghent-Leuven, Belgium. (13) Lab of Dendritic Cell Biology and Cancer Immunotherapy, VIB Center for Inflammation Research, Brussels, Belgium. Lab of Cellular and Molecular Immunology, Brussels Center for Immunology, Vrije Universiteit Brussel, Brussels, Belgium. (14) Laboratory of Cancer Signaling, GIGA-Institute, University of Lige, Lige, Belgium. Laboratory of Metabolic Regulation, GIGA-Institute, University of Lige, Lige, Belgium. (15) Laboratory of Cancer Signaling, GIGA-Institute, University of Lige, Lige, Belgium. WELBIO Department, WEL Research Institute, Wavre, Belgium. (16) Laboratory for ER Stress and Inflammation, VIB Center for Inflammation Research, Ghent, Belgium. Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium. (17) Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Swiss Federal Institute of Technology in Lausanne (EPFL), Lausanne, Switzerland. Agora Cancer Research Center, Lausanne, Switzerland. (18) Laboratory for Translational Genetics, Department of Human Genetics, KU Leuven, Leuven, Belgium. Laboratory for Translational Genetics, VIB Center for Cancer Biology, Leuven, Belgium. (19) Lab of Tumor Immunology and Immunotherapy, Department of Oncology, Leuven Cancer Institute, KU Leuven, Leuven, Belgium. (20) Lab of Dendritic Cell Biology and Cancer Immunotherapy, VIB Center for Inflammation Research, Brussels, Belgium. dlaoui@vub.be. Lab of Cellular and Molecular Immunology, Brussels Center for Immunology, Vrije Universiteit Brussel, Brussels, Belgium. dlaoui@vub.be.

Author Info: (1) Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Harvard Medical School, Boston, MA, USA. Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Author Info: (1) Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Harvard Medical School, Boston, MA, USA. Broad Institute of MIT and Harvard, Cambridge, MA, USA. Harvard/MIT MD-PhD Program and Harvard Immunology PhD Program, Harvard Medical School, Boston, MA, USA. (2) Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Harvard Medical School, Boston, MA, USA. Broad Institute of MIT and Harvard, Cambridge, MA, USA. Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Molecular Diagnostics Laboratory, Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. (3) Broad Institute of MIT and Harvard, Cambridge, MA, USA. (4) Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel. (5) Broad Institute of MIT and Harvard, Cambridge, MA, USA. (6) Broad Institute of MIT and Harvard, Cambridge, MA, USA. (7) Broad Institute of MIT and Harvard, Cambridge, MA, USA. (8) Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA. (9) Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada. (10) Harvard Medical School, Boston, MA, USA. Center for Neuro-Oncology, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. (11) Department of Radiation Oncology, Brigham and Women's Hospital, Boston, MA, USA. (12) Department of Imaging, Dana-Farber Cancer Institute, and Harvard Medical School, Boston, MA, USA. (13) Departments of Radiology, Mass General Brigham, Brigham and Women's Hospital, Dana-Farber Cancer Institute, and Harvard Medical School, Boston, MA, USA. (14) Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Translational Immunogenomics Laboratory, Dana-Farber Cancer Institute, Boston, MA, USA. (15) Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Translational Immunogenomics Laboratory, Dana-Farber Cancer Institute, Boston, MA, USA. (16) Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. (17) Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. (18) Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. (19) Departments of Radiology, Mass General Brigham, Brigham and Women's Hospital, Dana-Farber Cancer Institute, and Harvard Medical School, Boston, MA, USA. (20) Broad Institute of MIT and Harvard, Cambridge, MA, USA. (21) IBM Research, Yorktown Heights, NY, USA. (22) Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Broad Institute of MIT and Harvard, Cambridge, MA, USA. Translational Immunogenomics Laboratory, Dana-Farber Cancer Institute, Boston, MA, USA. (23) Center for Neuro-Oncology, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. (24) Center for Tumors of the Nervous System, Mass General Brigham Cancer Institute & Department of Neurosurgery, Mass General Brigham, Boston, MA, USA. (25) Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA. (26) Broad Institute of MIT and Harvard, Cambridge, MA, USA. Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Department of Pathology, Dana-Farber Cancer Institute, Boston, MA, USA. (27) Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel. (28) Center for Neuro-Oncology, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. (29) Harvard Medical School, Boston, MA, USA. Broad Institute of MIT and Harvard, Cambridge, MA, USA. Cancer Center and Department of Pathology, Massachusetts General Hospital, Boston, MA, USA. (30) Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. catherine_wu@dfci.harvard.edu. Harvard Medical School, Boston, MA, USA. catherine_wu@dfci.harvard.edu. Broad Institute of MIT and Harvard, Cambridge, MA, USA. catherine_wu@dfci.harvard.edu.

Author Info: (1) Oslo Center for Biostatistics and Epidemiology, University of Oslo, Oslo, Norway. younessazimzade@gmail.com. (2) Department of Tumor Biology, Institute for Cancer Research, Div

Author Info: (1) Oslo Center for Biostatistics and Epidemiology, University of Oslo, Oslo, Norway. younessazimzade@gmail.com. (2) Department of Tumor Biology, Institute for Cancer Research, Division of Cancer Medicine, Oslo University Hospital, The Norwegian Radium Hospital, Oslo, Norway. (3) Department of Medical Genetics, Oslo University Hospital, University of Oslo, Oslo, Norway. (4) Oslo Center for Biostatistics and Epidemiology, University of Oslo, Oslo, Norway. arnoldo.frigessi@medisin.uio.no. Oslo Center for Biostatistics and Epidemiology, Oslo University Hospital, Oslo, Norway. arnoldo.frigessi@medisin.uio.no. (5) Oslo Center for Biostatistics and Epidemiology, University of Oslo, Oslo, Norway. a.k.luque@medisin.uio.no. Oslo Center for Biostatistics and Epidemiology, Oslo University Hospital, Oslo, Norway. a.k.luque@medisin.uio.no.

Author Info: (1) University of Michigan-Ann Arbor Ann Arbor, MI United States. ROR: https://ror.org/00jmfr291 (2) University of Michigan-Ann Arbor Ann Arbor, MI United States. (3) University of

Author Info: (1) University of Michigan-Ann Arbor Ann Arbor, MI United States. ROR: https://ror.org/00jmfr291 (2) University of Michigan-Ann Arbor Ann Arbor, MI United States. (3) University of Michigan-Ann Arbor Ann Arbor, Michigan United States. ROR: https://ror.org/00jmfr291 (4) University of Michigan Medical Schooligan United States. (5) University of Michigan-Ann Arbor Ann Arbor, Michigan United States. ROR: https://ror.org/00jmfr291 (6) University of Michigan-Ann Arbor Ann Arbor, Michigan United States. ROR: https://ror.org/00jmfr291 (7) University of Michigan-Ann Arbor Ann Arbor, MI United States. ROR: https://ror.org/00jmfr291 (8) University of Michigan-Ann Arbor Ann Arbor, MI United States. ROR: https://ror.org/00jmfr291 (9) University of Michigan-Ann Arbor Ann Arbor, MI United States. ROR: https://ror.org/00jmfr291 (10) University of Michigan-Ann Arbor Ann Arbor, MI United States. ROR: https://ror.org/00jmfr291 (11) University of Michigan-Ann Arbor Ann Arbor United States. ROR: https://ror.org/00jmfr291 (12) University of Michigan-Ann Arbor United States. ROR: https://ror.org/00jmfr291 (13) University of Maryland, Baltimore Baltimore United States. ROR: https://ror.org/04rq5mt64 (14) University of Michigan-Ann Arbor Ann Arbor, Michigan United States. ROR: https://ror.org/00jmfr291 (15) University of Michigan-Ann Arbor Ann Arbor United States. ROR: https://ror.org/00jmfr291 (16) University of Michigan-Ann Arbor United States. ROR: https://ror.org/00jmfr291 (17) University of Michigan-Ann Arbor United States. ROR: https://ror.org/00jmfr291 (18) University of Michigan-Ann Arbor Ann Arbor, Michigan United States. ROR: https://ror.org/00jmfr291 (19) University of Michigan-Ann Arbor United States. ROR: https://ror.org/00jmfr291 (20) University of Michigan-Ann Arbor Ann Arbor, Michigan United States. ROR: https://ror.org/00jmfr291 (21) University of Michigan-Ann Arbor Ann Arbor, Michigan United States. ROR: https://ror.org/00jmfr291 (22) University of Michigan-Ann Arbor Ann Arbor, Michigan United States. ROR: https://ror.org/00jmfr291 (23) University of Michigan-Ann Arbor Ann Arbor United States. ROR: https://ror.org/00jmfr291 (24) University of Michigan-Ann Arbor United States. ROR: https://ror.org/00jmfr291 (25) Cornell University Ithaca United States. ROR: https://ror.org/05bnh6r87 (26) University of Michigan-Ann Arbor Ann Arbor, MI United States. ROR: https://ror.org/00jmfr291 (27) University of Michigan-Ann Arbor Ann Arbor, MI United States. ROR: https://ror.org/00jmfr291 (28) University of Michigan-Ann Arbor Ann Arbor, Michigan United States. ROR: https://ror.org/00jmfr291 (29) University of Michigan-Ann Arbor Ann Arbor, MI United States. ROR: https://ror.org/00jmfr291 (30) University of Michigan-Ann Arbor Ann Arbor, MI United States. ROR: https://ror.org/00jmfr291 (31) Cedars-Sinai Medical Center Los Angeles, CA United States. ROR: https://ror.org/02pammg90 (32) University of Michigan-Ann Arbor Ann Arbor, MI United States. ROR: https://ror.org/00jmfr291 (33) University of Michigan-Ann Arbor Ann Arbor, MI United States. ROR: https://ror.org/00jmfr291