Author Info: (1) Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, USA. Department of Biomedical Engineering, Washington University, St. Louis, MO, USA.

Author Info: (1) Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, USA. Department of Biomedical Engineering, Washington University, St. Louis, MO, USA. (2) Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, USA. Department of Biomedical Engineering, Washington University, St. Louis, MO, USA. (3) Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, USA. (4) Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, USA. (5) Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA. (6) Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, USA. (7) Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA. (8) Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA. (9) Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA. (10) Department of Biomedical Engineering, Washington University, St. Louis, MO, USA. Department of Radiology, Washington University School of Medicine, St. Louis, MO, USA. (11) Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA. (12) Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, USA. kareem.azab@wustl.edu. Department of Biomedical Engineering, Washington University, St. Louis, MO, USA. kareem.azab@wustl.edu.

Author Info: (1) Department of Radiotherapy / Oncology, Medical School, Democritus University of Thrace, Alexandroupolis 68100, Greece. Electronic address: targ@her.forthnet.gr. (2) Department

Author Info: (1) Department of Radiotherapy / Oncology, Medical School, Democritus University of Thrace, Alexandroupolis 68100, Greece. Electronic address: targ@her.forthnet.gr. (2) Department of Pathology, Medical School, Democritus University of Thrace, Alexandroupolis 68100, Greece.

Author Info: (1) Dermatopharmacology, Faculty of Medicine, University of Southampton, Southampton, UK. Dermatology, University Hospital Southampton NHS Foundation Trust, Southampton, UK. (2) De

Author Info: (1) Dermatopharmacology, Faculty of Medicine, University of Southampton, Southampton, UK. Dermatology, University Hospital Southampton NHS Foundation Trust, Southampton, UK. (2) Dermatopharmacology, Faculty of Medicine, University of Southampton, Southampton, UK. Dermatology, University Hospital Southampton NHS Foundation Trust, Southampton, UK. (3) Dermatopharmacology, Faculty of Medicine, University of Southampton, Southampton, UK. (4) Dermatopharmacology, Faculty of Medicine, University of Southampton, Southampton, UK. Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, UK. (5) Dermatopharmacology, Faculty of Medicine, University of Southampton, Southampton, UK. (6) Dermatopharmacology, Faculty of Medicine, University of Southampton, Southampton, UK. (7) Histopathology, University Hospital Southampton NHS Foundation Trust, Southampton, UK. (8) Histopathology, University Hospital Southampton NHS Foundation Trust, Southampton, UK. (9) Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, UK. Institute for Life Sciences, Faculty of Medicine, University of Southampton, Southampton, UK. (10) Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, UK. Centre for Cancer Immunology, University of Southampton, Southampton, UK. (11) Dermatopharmacology, Faculty of Medicine, University of Southampton, Southampton, UK e.healy@soton.ac.uk. Dermatology, University Hospital Southampton NHS Foundation Trust, Southampton, UK.

Author Info: (1) Department of Surgery, University of Virginia School of Medicine, Charlottesville, Virginia, USA cls8h@virginia.edu. University of Virginia Cancer Center, Charlottesville, Virg

Author Info: (1) Department of Surgery, University of Virginia School of Medicine, Charlottesville, Virginia, USA cls8h@virginia.edu. University of Virginia Cancer Center, Charlottesville, Virginia, USA. (2) University of Virginia Cancer Center, Charlottesville, Virginia, USA. Public Health Sciences, University of Virginia School of Medicine, Charlottesville, Virginia, USA. (3) Department of Surgery, University of Virginia School of Medicine, Charlottesville, Virginia, USA. University of Virginia Cancer Center, Charlottesville, Virginia, USA. (4) University of Virginia Cancer Center, Charlottesville, Virginia, USA. Public Health Sciences, University of Virginia School of Medicine, Charlottesville, Virginia, USA. (5) Department of Surgery, University of Virginia School of Medicine, Charlottesville, Virginia, USA. (6) Office of Research Cores Administration, University of Virginia School of Medicine, Charlottesville, Virginia, USA. (7) University of Virginia Cancer Center, Charlottesville, Virginia, USA. University of Virginia School of Medicine, Charlottesville, Virginia, USA. (8) Department of Surgery, University of Virginia School of Medicine, Charlottesville, Virginia, USA. University of Virginia Cancer Center, Charlottesville, Virginia, USA. (9) Department of Surgery, University of Virginia School of Medicine, Charlottesville, Virginia, USA. (10) Department of Gynecology and Obstetrics, Emory University, Atlanta, GA, USA. (11) Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, USA. (12) Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, USA. (13) Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, USA. (14) Public Health Sciences, University of Virginia School of Medicine, Charlottesville, Virginia, USA. (15) Public Health Sciences, University of Virginia School of Medicine, Charlottesville, Virginia, USA. (16) Cardiovascular Imaging Center, University of Virginia School of Medicine, Charlottesville, Virginia, USA. (17) Department of Surgery, University of Virginia School of Medicine, Charlottesville, Virginia, USA. (18) Department of Surgery, University of Virginia School of Medicine, Charlottesville, Virginia, USA. University of Virginia Cancer Center, Charlottesville, Virginia, USA.

Author Info: (1) KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul, South Korea. Center for Theragnosis, Biomedical Research Institute, Korea Institute of Sc

Author Info: (1) KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul, South Korea. Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul, South Korea. (2) Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul, South Korea. (3) Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul, South Korea. (4) Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul, South Korea. (5) KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul, South Korea. Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul, South Korea. (6) KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul, South Korea. Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul, South Korea. (7) Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul, South Korea. (8) KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul, South Korea. Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul, South Korea. (9) Otorhinolaryngology-Head and Neck Surgery, Korea University College of Medicine, Korea University Hospital, Seoul, South Korea. (10) Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul, South Korea. KHU-KIST Department of Converging Science and Technology, Kyunghee University, Seoul, South Korea. (11) KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul, South Korea iskim14@kist.re.kr sehoonkim@kist.re.kr. Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul, South Korea. (12) KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul, South Korea iskim14@kist.re.kr sehoonkim@kist.re.kr. Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul, South Korea.

Author Info: (1) McMaster Immunology Research Centre, Department of Medicine, McMaster University, Hamilton, Ontario, Canada. (2) McMaster Immunology Research Centre, Department of Medicine, Mc

Author Info: (1) McMaster Immunology Research Centre, Department of Medicine, McMaster University, Hamilton, Ontario, Canada. (2) McMaster Immunology Research Centre, Department of Medicine, McMaster University, Hamilton, Ontario, Canada. (3) McMaster Immunology Research Centre, Department of Medicine, McMaster University, Hamilton, Ontario, Canada. (4) McMaster Immunology Research Centre, Department of Medicine, McMaster University, Hamilton, Ontario, Canada. (5) McMaster Immunology Research Centre, Department of Medicine, McMaster University, Hamilton, Ontario, Canada. (6) Surgery, McMaster University, Hamilton, Ontario, Canada. (7) McMaster Immunology Research Centre, Department of Medicine, McMaster University, Hamilton, Ontario, Canada. (8) McMaster Immunology Research Centre, Department of Medicine, McMaster University, Hamilton, Ontario, Canada. (9) Surgery, McMaster University, Hamilton, Ontario, Canada. (10) McMaster Immunology Research Centre, Department of Medicine, McMaster University, Hamilton, Ontario, Canada ashkara@mcmaster.ca.

Author Info: (1) Department of Chemical & Biological Engineering, Villanova University, 800 East Lancaster Avenue, Villanova, PA, USA, 19085. (2) Department of Chemical & Biological Engineering

Author Info: (1) Department of Chemical & Biological Engineering, Villanova University, 800 East Lancaster Avenue, Villanova, PA, USA, 19085. (2) Department of Chemical & Biological Engineering, Villanova University, 800 East Lancaster Avenue, Villanova, PA, USA, 19085. (3) Department of Chemical & Biological Engineering, Villanova University, 800 East Lancaster Avenue, Villanova, PA, USA, 19085. (4) Department of Biology, Villanova University, 800 East Lancaster Avenue, Villanova, PA, USA, 19085. (5) Department of Chemical & Biological Engineering, Villanova University, 800 East Lancaster Avenue, Villanova, PA, USA, 19085.

Author Info: (1) Institute of Diabetes Research and Metabolic Diseases (IDM), the Helmholtz Center, Munich, Germany. norbert.stefan@med.uni-tuebingen.de. Department of Internal Medicine IV, Div

Author Info: (1) Institute of Diabetes Research and Metabolic Diseases (IDM), the Helmholtz Center, Munich, Germany. norbert.stefan@med.uni-tuebingen.de. Department of Internal Medicine IV, Division of Endocrinology, Diabetology and Nephrology, University Hospital of TŸbingen, TŸbingen, Germany. norbert.stefan@med.uni-tuebingen.de. German Center for Diabetes Research (DZD), Neuherberg, Germany. norbert.stefan@med.uni-tuebingen.de. (2) Institute of Diabetes Research and Metabolic Diseases (IDM), the Helmholtz Center, Munich, Germany. Department of Internal Medicine IV, Division of Endocrinology, Diabetology and Nephrology, University Hospital of TŸbingen, TŸbingen, Germany. German Center for Diabetes Research (DZD), Neuherberg, Germany. Department of Diabetes, School of Life Course Science, King's College London, London, UK. (3) German Center for Diabetes Research (DZD), Neuherberg, Germany. Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany. Institute of Nutritional Science, University of Potsdam, Potsdam, Germany.

Author Info: (1) Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. (2) Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Harvard Medica

Author Info: (1) Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. (2) Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Harvard Medical School, Boston, MA, USA. (3) Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. (4) Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. (5) Broad Institute of MIT and Harvard, Cambridge, MA, USA. Translational Immunogenomics Laboratory, Dana-Farber Cancer Institute, Boston, MA, USA. (6) Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA. (7) Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA. (8) Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Broad Institute of MIT and Harvard, Cambridge, MA, USA. Translational Immunogenomics Laboratory, Dana-Farber Cancer Institute, Boston, MA, USA. (9) Translational Immunogenomics Laboratory, Dana-Farber Cancer Institute, Boston, MA, USA. (10) Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Harvard Medical School, Boston, MA, USA. Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA. (11) Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA. (12) Broad Institute of MIT and Harvard, Cambridge, MA, USA. (13) Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Broad Institute of MIT and Harvard, Cambridge, MA, USA. Department of Academic Haematology, University College London, London, UK. (14) Department of Data Sciences, Dana-Farber Cancer Institute, Boston, MA, USA. (15) Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. (16) Broad Institute of MIT and Harvard, Cambridge, MA, USA. (17) Department of Data Sciences, Dana-Farber Cancer Institute, Boston, MA, USA. (18) Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. (19) Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA. (20) Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. (21) Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA. Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. (22) Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. (23) Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. (24) Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA. (25) Department of Data Sciences, Dana-Farber Cancer Institute, Boston, MA, USA. Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. (26) Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Harvard Medical School, Boston, MA, USA. (27) Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Harvard Medical School, Boston, MA, USA. Broad Institute of MIT and Harvard, Cambridge, MA, USA. Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA. (28) Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Harvard Medical School, Boston, MA, USA. Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA. (29) Harvard Medical School, Boston, MA, USA. Department of Surgery, Brigham and Women's Hospital, Boston, MA, USA. (30) Department of Data Sciences, Dana-Farber Cancer Institute, Boston, MA, USA. (31) Broad Institute of MIT and Harvard, Cambridge, MA, USA. Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA. The Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA. (32) Harvard Medical School, Boston, MA, USA. Broad Institute of MIT and Harvard, Cambridge, MA, USA. Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA. (33) Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Translational Immunogenomics Laboratory, Dana-Farber Cancer Institute, Boston, MA, USA. (34) Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Broad Institute of MIT and Harvard, Cambridge, MA, USA. Translational Immunogenomics Laboratory, Dana-Farber Cancer Institute, Boston, MA, USA. (35) Section for Bioinformatics, Department of Health Technology, Technical University of Denmark, Lyngby, Denmark. Center for Genomic Medicine, Copenhagen University Hospital, Copenhagan, Denmark. (36) Harvard Medical School, Boston, MA, USA. Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA. Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA. (37) Harvard Medical School, Boston, MA, USA. Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA. (38) Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Broad Institute of MIT and Harvard, Cambridge, MA, USA. (39) Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Broad Institute of MIT and Harvard, Cambridge, MA, USA. Translational Immunogenomics Laboratory, Dana-Farber Cancer Institute, Boston, MA, USA. (40) Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Harvard Medical School, Boston, MA, USA. Broad Institute of MIT and Harvard, Cambridge, MA, USA. Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA. (41) Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. patrick_ott@dfci.harvard.edu. Harvard Medical School, Boston, MA, USA. patrick_ott@dfci.harvard.edu. Broad Institute of MIT and Harvard, Cambridge, MA, USA. patrick_ott@dfci.harvard.edu. Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA. patrick_ott@dfci.harvard.edu.

Author Info: (1) Department of Immunology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands. (2) Department of Immunology, Leiden University Medical Center, 2333 ZA Leiden, The

Author Info: (1) Department of Immunology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands. (2) Department of Immunology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands. (3) Department of Immunology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.