Author Info: (1) The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA. (2) Netherlands Cancer Institute, Amsterdam, The Netherlands. (3

Author Info: (1) The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA. (2) Netherlands Cancer Institute, Amsterdam, The Netherlands. (3) The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA. (4) The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA. (5) Netherlands Cancer Institute, Amsterdam, The Netherlands. (6) The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA. The Bloomberg~Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, USA. (7) The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA. (8) The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA. (9) The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA. (10) The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA. (11) The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD, USA. (12) The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA. (13) Department of Pulmonary Diseases, Radboud University Medical Center, Nijmegen, The Netherlands. (14) The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA. (15) The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA. The Bloomberg~Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, USA. (16) Netherlands Cancer Institute, Amsterdam, The Netherlands. (17) The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA. vanagno1@jhmi.edu. The Bloomberg~Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, USA. vanagno1@jhmi.edu.

Author Info: (1) Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark. (2) Department of Biotechnology and Biomedicine, Technical University of Denmark, Kon

Author Info: (1) Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark. (2) Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark. (3) Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark. Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark. (4) Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA. (5) Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark. Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark. (6) Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA. (7) Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark. (8) Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark. (9) Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark. (10) Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark. (11) Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark. (12) Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark. (13) Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark. (14) Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark. (15) Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA. (16) Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA. (17) Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark. (18) Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark. (19) Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark. (20) Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark. (21) Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark. (22) Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark. (23) Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark. (24) Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA. (25) Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark. (26) Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark. (27) Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.

Author Info: (1) Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA. Program in Immunology, Stanford University School of Medicine, Stanf

Author Info: (1) Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA. Program in Immunology, Stanford University School of Medicine, Stanford, CA, USA. (2) Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA. (3) Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA. (4) Department of Computer Science, Stanford University, Stanford, CA, USA. (5) Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA. (6) Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA. (7) Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA. (8) Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA. (9) Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA. Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA, USA. (10) Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA. Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA, USA. Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA.

Author Info: (1) Department of Biochemistry, University of Washington, Seattle, WA, USA. Institute for Protein Design, University of Washington, Seattle, WA, USA. (2) Department of Biochemistry

Author Info: (1) Department of Biochemistry, University of Washington, Seattle, WA, USA. Institute for Protein Design, University of Washington, Seattle, WA, USA. (2) Department of Biochemistry, University of Washington, Seattle, WA, USA. Institute for Protein Design, University of Washington, Seattle, WA, USA. (3) Department of Biochemistry, University of Washington, Seattle, WA, USA. Institute for Protein Design, University of Washington, Seattle, WA, USA. Bioengineering Graduate Program, University of Washington, Seattle, WA, USA. (4) Department of Biochemistry, University of Washington, Seattle, WA, USA. Institute for Protein Design, University of Washington, Seattle, WA, USA. Bioengineering Graduate Program, University of Washington, Seattle, WA, USA. (5) Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. (6) Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. (7) Departments of Molecular and Cellular Physiology and Structural Biology, Stanford University School of Medicine, Stanford, CA, USA. (8) Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA. Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. (9) Department of Biochemistry, University of Washington, Seattle, WA, USA. Institute for Protein Design, University of Washington, Seattle, WA, USA. (10) Departments of Molecular and Cellular Physiology and Structural Biology, Stanford University School of Medicine, Stanford, CA, USA. (11) Paul G. Allen School of Computer Science and Engineering, University of Washington, Seattle, WA, USA. (12) Department of Biochemistry, University of Washington, Seattle, WA, USA. Institute for Protein Design, University of Washington, Seattle, WA, USA. (13) Department of Biochemistry, University of Washington, Seattle, WA, USA. Institute for Protein Design, University of Washington, Seattle, WA, USA. (14) Paul G. Allen School of Computer Science and Engineering, University of Washington, Seattle, WA, USA. Department of Physics, University of Washington, Seattle, WA, USA. Department of Applied Mathematics, University of Washington, Seattle, WA, USA. Fred Hutchinson Cancer Center, Seattle, WA, USA. (15) Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Weill Cornell Medicine, New York, NY, USA. (16) Departments of Molecular and Cellular Physiology and Structural Biology, Stanford University School of Medicine, Stanford, CA, USA. Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA. (17) Department of Biochemistry, University of Washington, Seattle, WA, USA. Institute for Protein Design, University of Washington, Seattle, WA, USA. Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA.

Author Info: (1) Division of Cancer Immunology, National Cancer Center Research Institute, Tokyo, Japan. Department of Immunology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Author Info: (1) Division of Cancer Immunology, National Cancer Center Research Institute, Tokyo, Japan. Department of Immunology, Nagoya University Graduate School of Medicine, Nagoya, Japan. (2) Division of Cancer Immunology, National Cancer Center Research Institute, Tokyo, Japan. (3) Division of Cancer Immunology, National Cancer Center Research Institute, Tokyo, Japan. Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Osaka, Japan. (4) Department of Infection Metagenomics, Genome Information Research Center, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan. (5) Molecular Biosystems Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Ibaraki, Japan. (6) Benno Laboratory, RIKEN Baton Zone Program, RIKEN Cluster for Science Technology and Innovation Laboratory, Saitama, Japan. (7) Department of Infection Metagenomics, Genome Information Research Center, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan. (8) Department of Infection Metagenomics, Genome Information Research Center, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan. (9) Molecular Biosystems Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Ibaraki, Japan. (10) Biomanufacturing Process Research Center, National Institute of Advanced Industrial Science and Technology (AIST), Ibaraki, Japan. (11) Division of Cancer Immunology, National Cancer Center Research Institute, Tokyo, Japan. (12) Division of Cancer Immunology, National Cancer Center Research Institute, Tokyo, Japan. Department of Thoracic Oncology, National Cancer Center Hospital East, Chiba, Japan. (13) Division of Cancer Immunology, National Cancer Center Research Institute, Tokyo, Japan. Division of Cellular Signaling, National Cancer Center Research Institute, Tokyo, Japan. (14) Division of Cancer Immunology, National Cancer Center Research Institute, Tokyo, Japan. (15) Division of Cancer Immunology, National Cancer Center Research Institute, Tokyo, Japan. (16) Department of Immunology, Nagoya University Graduate School of Medicine, Nagoya, Japan. (17) Department of Immunology, Nagoya University Graduate School of Medicine, Nagoya, Japan. (18) Department of Anatomy and Molecular Cell Biology, Nagoya University Graduate School of Medicine, Nagoya, Japan. (19) Department of Anatomy and Molecular Cell Biology, Nagoya University Graduate School of Medicine, Nagoya, Japan. (20) Department of Anatomy and Molecular Cell Biology, Nagoya University Graduate School of Medicine, Nagoya, Japan. (21) Division of Cancer Immunology, National Cancer Center Research Institute, Tokyo, Japan. (22) Division of Cancer Immunology, National Cancer Center Research Institute, Tokyo, Japan. (23) Department of Head and Neck Medical Oncology, National Cancer Center Hospital East, Chiba, Japan. (24) Department of Head and Neck Medical Oncology, National Cancer Center Hospital East, Chiba, Japan. (25) Division of Translational Informatics, Exploratory Oncology Research and Clinical Trial Center (EPOC), National Cancer Center, Chiba, Japan. (26) Department of Head and Neck Medical Oncology, National Cancer Center Hospital East, Chiba, Japan. Translational Research Support Office, National Cancer Center Hospital East, Chiba, Japan. (27) Department of Head and Neck Oncology and Innovative Treatment, Graduate School of Medicine, Kyoto University, Kyoto, Japan. (28) Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Chiba, Japan. (29) Department of Thoracic Oncology, National Cancer Center Hospital East, Chiba, Japan. (30) Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Chiba, Japan. (31) Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Chiba, Japan. (32) Division of Cellular Signaling, National Cancer Center Research Institute, Tokyo, Japan. (33) Molecular Biosystems Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Ibaraki, Japan. (34) Department of Infection Metagenomics, Genome Information Research Center, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan. (35) Benno Laboratory, RIKEN Baton Zone Program, RIKEN Cluster for Science Technology and Innovation Laboratory, Saitama, Japan. benno828@bigm.or.jp. Benno Institute for Gut Microflora (BIGM), Saitama Industrial Technology Center, Saitama, Japan. benno828@bigm.or.jp. (36) Division of Cancer Immunology, National Cancer Center Research Institute, Tokyo, Japan. hnishika@ncc.go.jp. Department of Immunology, Nagoya University Graduate School of Medicine, Nagoya, Japan. hnishika@ncc.go.jp. Division of Cancer Immune Multicellular System Regulation, Center for Cancer Immunotherapy and Immunobiology, Kyoto University Graduate School of Medicine, Kyoto, Japan. hnishika@ncc.go.jp. Kindai University Faculty of Medicine, Osaka, Japan. hnishika@ncc.go.jp.

Author Info: (1) Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. Liangzhu Laboratory, Zhejiang University, Hangzhou,

Author Info: (1) Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. Liangzhu Laboratory, Zhejiang University, Hangzhou, China. (2) Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. Liangzhu Laboratory, Zhejiang University, Hangzhou, China. Department of Cell Biology, Zhejiang University School of Medicine, Hangzhou, China. Institute of Hematology, Zhejiang Engineering Laboratory for Stem Cell and Immunotherapy, Zhejiang University, Hangzhou, China. (3) Liangzhu Laboratory, Zhejiang University, Hangzhou, China. Department of Cell Biology, Zhejiang University School of Medicine, Hangzhou, China. Institute of Hematology, Zhejiang Engineering Laboratory for Stem Cell and Immunotherapy, Zhejiang University, Hangzhou, China. (4) Liangzhu Laboratory, Zhejiang University, Hangzhou, China. Department of Cell Biology, Zhejiang University School of Medicine, Hangzhou, China. Institute of Hematology, Zhejiang Engineering Laboratory for Stem Cell and Immunotherapy, Zhejiang University, Hangzhou, China. (5) Liangzhu Laboratory, Zhejiang University, Hangzhou, China. Department of Cell Biology, Zhejiang University School of Medicine, Hangzhou, China. Institute of Hematology, Zhejiang Engineering Laboratory for Stem Cell and Immunotherapy, Zhejiang University, Hangzhou, China. (6) Liangzhu Laboratory, Zhejiang University, Hangzhou, China. Department of Cell Biology, Zhejiang University School of Medicine, Hangzhou, China. Institute of Hematology, Zhejiang Engineering Laboratory for Stem Cell and Immunotherapy, Zhejiang University, Hangzhou, China. (7) School of Public Health, Zhejiang University School of Medicine, Hangzhou, China. (8) School of Public Health, Zhejiang University School of Medicine, Hangzhou, China. (9) Center for Cell Engineering and Immunology Program, Sloan Kettering Institute, New York, NY, USA. (10) Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. huanghe@zju.edu.cn. Liangzhu Laboratory, Zhejiang University, Hangzhou, China. huanghe@zju.edu.cn. Institute of Hematology, Zhejiang Engineering Laboratory for Stem Cell and Immunotherapy, Zhejiang University, Hangzhou, China. huanghe@zju.edu.cn. (11) Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. sunj4@zju.edu.cn. Liangzhu Laboratory, Zhejiang University, Hangzhou, China. sunj4@zju.edu.cn. Department of Cell Biology, Zhejiang University School of Medicine, Hangzhou, China. sunj4@zju.edu.cn. Institute of Hematology, Zhejiang Engineering Laboratory for Stem Cell and Immunotherapy, Zhejiang University, Hangzhou, China. sunj4@zju.edu.cn.

Author Info: (1) Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden. (2) Center for Infectious Medicine, Department of Medicine Huddinge,

Author Info: (1) Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden. (2) Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden. (3) Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden. (4) Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden. (5) Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden. (6) Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden. (7) Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden. (8) Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden. (9) Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden. (10) Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden. (11) Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden. (12) Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden. (13) Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden. (14) Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden. (15) Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden. (16) Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden. (17) Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden. (18) Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden. (19) Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden. (20) Center for Hematology and Regenerative Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden. (21) Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden. (22) Center for Hematology and Regenerative Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden. (23) Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden. (24) Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden. (25) Division of Infection and Immunity, Cardiff University School of Medicine, University Hospital of Wales, Cardiff, UK. (26) Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden. (27) Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden. (28) Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden. (29) Division of Infection and Immunity, Cardiff University School of Medicine, University Hospital of Wales, Cardiff, UK. Systems Immunity Research Institute, Cardiff University School of Medicine, University Hospital of Wales, Cardiff, UK. (30) Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden. (31) Center for Hematology and Regenerative Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden. (32) Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden. (33) Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden. (34) ME Transplantation, Karolinska University Hospital Huddinge, Stockholm, Sweden. Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden. (35) Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.

Author Info: (1) Lillian S. Wells Department of Neurosurgery, Preston A. Wells, Jr. Center for Brain Tumor Therapy, McKnight Brain Institute, University of Florida, Gainesville, FL, USA. Univer

Author Info: (1) Lillian S. Wells Department of Neurosurgery, Preston A. Wells, Jr. Center for Brain Tumor Therapy, McKnight Brain Institute, University of Florida, Gainesville, FL, USA. University of Florida Genetics Institute, University of Florida, Gainesville, FL, USA. (2) Lillian S. Wells Department of Neurosurgery, Preston A. Wells, Jr. Center for Brain Tumor Therapy, McKnight Brain Institute, University of Florida, Gainesville, FL, USA. (3) Department of Pediatrics, Division of Pediatric Hematology-Oncology, UF Health Cancer Center, University of Florida, Gainesville, FL, USA. (4) Lillian S. Wells Department of Neurosurgery, Preston A. Wells, Jr. Center for Brain Tumor Therapy, McKnight Brain Institute, University of Florida, Gainesville, FL, USA. (5) Lillian S. Wells Department of Neurosurgery, Preston A. Wells, Jr. Center for Brain Tumor Therapy, McKnight Brain Institute, University of Florida, Gainesville, FL, USA. (6) Lillian S. Wells Department of Neurosurgery, Preston A. Wells, Jr. Center for Brain Tumor Therapy, McKnight Brain Institute, University of Florida, Gainesville, FL, USA. (7) Lillian S. Wells Department of Neurosurgery, Preston A. Wells, Jr. Center for Brain Tumor Therapy, McKnight Brain Institute, University of Florida, Gainesville, FL, USA. (8) Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. (9) Lillian S. Wells Department of Neurosurgery, Preston A. Wells, Jr. Center for Brain Tumor Therapy, McKnight Brain Institute, University of Florida, Gainesville, FL, USA. (10) Lillian S. Wells Department of Neurosurgery, Preston A. Wells, Jr. Center for Brain Tumor Therapy, McKnight Brain Institute, University of Florida, Gainesville, FL, USA. (11) Lillian S. Wells Department of Neurosurgery, Preston A. Wells, Jr. Center for Brain Tumor Therapy, McKnight Brain Institute, University of Florida, Gainesville, FL, USA. (12) Lillian S. Wells Department of Neurosurgery, Preston A. Wells, Jr. Center for Brain Tumor Therapy, McKnight Brain Institute, University of Florida, Gainesville, FL, USA. (13) Lillian S. Wells Department of Neurosurgery, Preston A. Wells, Jr. Center for Brain Tumor Therapy, McKnight Brain Institute, University of Florida, Gainesville, FL, USA. (14) Department of Pediatrics, Division of Pediatric Hematology-Oncology, UF Health Cancer Center, University of Florida, Gainesville, FL, USA. (15) Lillian S. Wells Department of Neurosurgery, Preston A. Wells, Jr. Center for Brain Tumor Therapy, McKnight Brain Institute, University of Florida, Gainesville, FL, USA. (16) Lillian S. Wells Department of Neurosurgery, Preston A. Wells, Jr. Center for Brain Tumor Therapy, McKnight Brain Institute, University of Florida, Gainesville, FL, USA. (17) Department of Pediatrics, Division of Pediatric Hematology-Oncology, UF Health Cancer Center, University of Florida, Gainesville, FL, USA. (18) Lillian S. Wells Department of Neurosurgery, Preston A. Wells, Jr. Center for Brain Tumor Therapy, McKnight Brain Institute, University of Florida, Gainesville, FL, USA. (19) Lillian S. Wells Department of Neurosurgery, Preston A. Wells, Jr. Center for Brain Tumor Therapy, McKnight Brain Institute, University of Florida, Gainesville, FL, USA. (20) Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, FL, USA. (21) Department of Medicine, Division of Hematology and Oncology, UF Health Cancer Center, University of Florida, Gainesville, FL, USA. (22) Lillian S. Wells Department of Neurosurgery, Preston A. Wells, Jr. Center for Brain Tumor Therapy, McKnight Brain Institute, University of Florida, Gainesville, FL, USA. (23) Department of Pediatrics, Division of Pediatric Hematology-Oncology, UF Health Cancer Center, University of Florida, Gainesville, FL, USA. (24) Lillian S. Wells Department of Neurosurgery, Preston A. Wells, Jr. Center for Brain Tumor Therapy, McKnight Brain Institute, University of Florida, Gainesville, FL, USA. (25) Lillian S. Wells Department of Neurosurgery, Preston A. Wells, Jr. Center for Brain Tumor Therapy, McKnight Brain Institute, University of Florida, Gainesville, FL, USA. (26) Lillian S. Wells Department of Neurosurgery, Preston A. Wells, Jr. Center for Brain Tumor Therapy, McKnight Brain Institute, University of Florida, Gainesville, FL, USA. (27) Department of Pediatrics, Division of Pediatric Hematology-Oncology, UF Health Cancer Center, University of Florida, Gainesville, FL, USA. (28) Lillian S. Wells Department of Neurosurgery, Preston A. Wells, Jr. Center for Brain Tumor Therapy, McKnight Brain Institute, University of Florida, Gainesville, FL, USA. (29) Lillian S. Wells Department of Neurosurgery, Preston A. Wells, Jr. Center for Brain Tumor Therapy, McKnight Brain Institute, University of Florida, Gainesville, FL, USA. (30) College of Veterinary Medicine, University of Florida, Gainesville, FL, USA. (31) Department of Pathology, University of Florida, Gainesville, FL, USA. (32) Center of Immunotherapy and Precision Immuno-Oncology/Head and Neck Institute, Cleveland Clinic, Cleveland, OH, USA. (33) Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, FL, USA. (34) Lillian S. Wells Department of Neurosurgery, Preston A. Wells, Jr. Center for Brain Tumor Therapy, McKnight Brain Institute, University of Florida, Gainesville, FL, USA. (35) Department of Pediatrics, Division of Pediatric Hematology-Oncology, UF Health Cancer Center, University of Florida, Gainesville, FL, USA. (36) Lillian S. Wells Department of Neurosurgery, Preston A. Wells, Jr. Center for Brain Tumor Therapy, McKnight Brain Institute, University of Florida, Gainesville, FL, USA. (37) Department of Biostatistics, University of Florida, Gainesville, FL, USA. (38) Lillian S. Wells Department of Neurosurgery, Preston A. Wells, Jr. Center for Brain Tumor Therapy, McKnight Brain Institute, University of Florida, Gainesville, FL, USA. (39) Department of Pediatrics, Division of Pediatric Hematology-Oncology, UF Health Cancer Center, University of Florida, Gainesville, FL, USA. (40) Lillian S. Wells Department of Neurosurgery, Preston A. Wells, Jr. Center for Brain Tumor Therapy, McKnight Brain Institute, University of Florida, Gainesville, FL, USA. (41) Lillian S. Wells Department of Neurosurgery, Preston A. Wells, Jr. Center for Brain Tumor Therapy, McKnight Brain Institute, University of Florida, Gainesville, FL, USA. Elias.Sayour@neurosurgery.ufl.edu. Department of Pediatrics, Division of Pediatric Hematology-Oncology, UF Health Cancer Center, University of Florida, Gainesville, FL, USA. Elias.Sayour@neurosurgery.ufl.edu.

Author Info: (1) Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT 065

Author Info: (1) Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA. (2) Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA. (3) Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA. (4) Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA. (5) Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA. (6) Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA. (7) Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA. (8) Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA. (9) Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA. (10) Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA. (11) Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA. (12) Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA. Department of Pathology, Yale University School of Medicine, New Haven, CT 06520, USA. (13) Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA. (14) Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA. Department of Biomedical Engineering, Yale University, New Haven, CT 06520, USA. (15) Gennao Bio, Hopewell, NJ 08525, USA. (16) Gennao Bio, Hopewell, NJ 08525, USA. (17) Gennao Bio, Hopewell, NJ 08525, USA. (18) Department of Medicine (Medical Oncology), Yale University School of Medicine, New Haven, CT 06520, USA. Department of Urology, Akita University School of Medicine, Akita, 010-8543, Japan. (19) Department of Bioengineering, University of Illinois, Urbana-Champaign, Urbana, IL 61801, USA. (20) Department of Bioengineering, University of Illinois, Urbana-Champaign, Urbana, IL 61801, USA. Carl R. Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA. (21) Gennao Bio, Hopewell, NJ 08525, USA. (22) Gennao Bio, Hopewell, NJ 08525, USA. (23) Gennao Bio, Hopewell, NJ 08525, USA. (24) Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA. Department of Pathology, Yale University School of Medicine, New Haven, CT 06520, USA. (25) Department of Pathology, Yale University School of Medicine, New Haven, CT 06520, USA. (26) Department of Medicine (Medical Oncology), Yale University School of Medicine, New Haven, CT 06520, USA. (27) Department of Bioengineering, University of Illinois, Urbana-Champaign, Urbana, IL 61801, USA. Carl R. Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA. Cancer Center at Illinois, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA. (28) Department of Biomedical Engineering, Yale University, New Haven, CT 06520, USA. (29) Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA. Department of Medicine (Medical Oncology), Yale University School of Medicine, New Haven, CT 06520, USA. Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA. (30) Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA.

Author Info: (1) Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA. (2) Department of Pathobiology, School of Veterinary Medicine, Uni

Author Info: (1) Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA. (2) Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA. (3) Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA. (4) Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA. (5) Department of Immunology, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada. (6) Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA. (7) Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA. (8) Acuitas Therapeutics, Vancouver, BC, Canada. (9) Department of Immunology, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada. (10) Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Penn Institute for RNA Innovation, University of Pennsylvania, Philadelphia, PA, USA. (11) Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA. (12) Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA. pscott@upenn.edu.