Author Info: (1) Institute of Immunology, Hannover Medical School, Hannover, Germany. (2) Institute of Immunology, Hannover Medical School, Hannover, Germany. (3) Institute of Immunology, Hanno

Author Info: (1) Institute of Immunology, Hannover Medical School, Hannover, Germany. (2) Institute of Immunology, Hannover Medical School, Hannover, Germany. (3) Institute of Immunology, Hannover Medical School, Hannover, Germany. (4) Institute of Immunology, Hannover Medical School, Hannover, Germany. (5) Institute of Immunology, Hannover Medical School, Hannover, Germany. Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, Germany.

Author Info: (1) Department of Pathology and Laboratory Medicine, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States. Department of

Author Info: (1) Department of Pathology and Laboratory Medicine, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States. Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA, United States. Pharmacology Graduate Group, University of Pennsylvania, Philadelphia, PA, United States. Center for Cellular Immunotherapies, University of Pennsylvania School of Medicine, Philadelphia, PA, United States. (2) Department of Pathology and Laboratory Medicine, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States. Center for Cellular Immunotherapies, University of Pennsylvania School of Medicine, Philadelphia, PA, United States. Department of Cancer Biology, University of Pennsylvania School of Medicine, Philadelphia, PA, United States. (3) Department of Pathology and Laboratory Medicine, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States. Center for Cellular Immunotherapies, University of Pennsylvania School of Medicine, Philadelphia, PA, United States.

Author Info: (1) Institute of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland; Molecular Life Sciences Ph.D. Program, Life Science Zurich Gradua

Author Info: (1) Institute of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland; Molecular Life Sciences Ph.D. Program, Life Science Zurich Graduate School, ETH Zurich and University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland. (2) IBM Research Zurich, Saeumerstrasse 4, 8803 Rueschlikon, Switzerland. (3) Institute of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland. (4) Patients' Tumor Bank of Hope (PATH) Biobank, PO 750729, 81337 Munich, Germany. (5) Institute of Pathology at Josefshaus, Amalienstrasse 21, 44137 Dortmund, Germany. (6) Institute of Pathology at Josefshaus, Amalienstrasse 21, 44137 Dortmund, Germany. (7) Institute of Pathology at Josefshaus, Amalienstrasse 21, 44137 Dortmund, Germany. (8) Institute of Pathology, University Hospital Giessen and Marburg, Baldingerstrasse, 35043 Marburg, Germany. (9) Institute of Pathology, University Hospital Basel and University of Basel, Schoenbeinstrasse 40, 4031 Basel, Switzerland. (10) Clarunis, University Hospital Basel and University of Basel, Spitalstrasse 21, 4031 Basel, Switzerland; Breast Cancer Center, University Hospital Basel and University of Basel, Spitalstrasse 21, 4031 Basel, Switzerland. (11) Institute of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland. (12) Institute of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland; Systems Biology Ph.D. Program, Life Science Zurich Graduate School, ETH Zurich and University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland. (13) Institute of Experimental Immunology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland. (14) Institute of Experimental Immunology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland. (15) Breast Cancer Center, University Hospital Zurich, Frauenklinikstrasse 10, 8091 Zurich, Switzerland. (16) IBM Research Zurich, Saeumerstrasse 4, 8803 Rueschlikon, Switzerland. (17) Breast Cancer Center, University Hospital Basel and University of Basel, Spitalstrasse 21, 4031 Basel, Switzerland; Department of Surgery, University Hospital Basel and University of Basel, Spitalstrasse 21, 4031 Basel, Switzerland. (18) Institute of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland. Electronic address: bernd.bodenmiller@imls.uzh.ch.

Author Info: (1) State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Ruijin Hospital affiliated with Shanghai Jiao T

Author Info: (1) State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China. (2) Department of Hematology, Jiangsu Province Hospital, First Affiliated Hospital of Nanjing Medical University, 210029 Nanjing, China. (3) State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China. (4) State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China. (5) State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China. (6) State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China. (7) Department of Hematology, Jiangsu Province Hospital, First Affiliated Hospital of Nanjing Medical University, 210029 Nanjing, China. (8) Department of Hematology, Changzheng Hospital, The Second Military Medical University, 200003 Shanghai, China. (9) State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China. (10) State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China. (11) State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China. (12) State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China. (13) State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China. (14) State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China. (15) State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China. (16) Department of Hematology, Changzheng Hospital, The Second Military Medical University, 200003 Shanghai, China. (17) Department of Hematology, Changzheng Hospital, The Second Military Medical University, 200003 Shanghai, China. (18) Department of Radiology and Nuclear Medicine, Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China. (19) Department of Radiology and Nuclear Medicine, Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China. (20) State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China. (21) Department of Hematology, Changzheng Hospital, The Second Military Medical University, 200003 Shanghai, China. (22) State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China. (23) Nanjing Legend Biotech, 210008 Nanjing, China. (24) State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China; zchen@stn.sh.cn frank.fan@legendbiotech.com houjian@medmail.com.cn lijianyonglm@medmail.com.cn jianqingmi@shsmu.edu.cn sjchen@stn.sh.cn. (25) Nanjing Legend Biotech, 210008 Nanjing, China zchen@stn.sh.cn frank.fan@legendbiotech.com houjian@medmail.com.cn lijianyonglm@medmail.com.cn jianqingmi@shsmu.edu.cn sjchen@stn.sh.cn. (26) Department of Hematology, Changzheng Hospital, The Second Military Medical University, 200003 Shanghai, China; zchen@stn.sh.cn frank.fan@legendbiotech.com houjian@medmail.com.cn lijianyonglm@medmail.com.cn jianqingmi@shsmu.edu.cn sjchen@stn.sh.cn. (27) Department of Hematology, Jiangsu Province Hospital, First Affiliated Hospital of Nanjing Medical University, 210029 Nanjing, China; zchen@stn.sh.cn frank.fan@legendbiotech.com houjian@medmail.com.cn lijianyonglm@medmail.com.cn jianqingmi@shsmu.edu.cn sjchen@stn.sh.cn. (28) State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China; zchen@stn.sh.cn frank.fan@legendbiotech.com houjian@medmail.com.cn lijianyonglm@medmail.com.cn jianqingmi@shsmu.edu.cn sjchen@stn.sh.cn. (29) State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China; zchen@stn.sh.cn frank.fan@legendbiotech.com houjian@medmail.com.cn lijianyonglm@medmail.com.cn jianqingmi@shsmu.edu.cn sjchen@stn.sh.cn.

Author Info: (1) Institute for Research in Biomedicine (IRB Barcelona), the Barcelona Institute of Science and Technology, Baldiri Reixac 10, 08028 Barcelona, Spain; Centro de Investigacion Bio

Author Info: (1) Institute for Research in Biomedicine (IRB Barcelona), the Barcelona Institute of Science and Technology, Baldiri Reixac 10, 08028 Barcelona, Spain; Centro de Investigacion Biomedica en Red de Cancer (CIBERONC), Barcelona, Spain; ICREA, Passeig Lluis Companys 23, 08010 Barcelona, Spain. Electronic address: eduard.batlle@irbbarcelona.org. (2) Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address: j-massague@ski.mskcc.org.

Author Info: (1) Alligator Bioscience AB, Medicon Village, Scheelevagen 2, 223 81, Lund, Sweden. amk@alligatorbioscience.com. (2) Alligator Bioscience AB, Medicon Village, Scheelevagen 2, 223 8

Author Info: (1) Alligator Bioscience AB, Medicon Village, Scheelevagen 2, 223 81, Lund, Sweden. amk@alligatorbioscience.com. (2) Alligator Bioscience AB, Medicon Village, Scheelevagen 2, 223 81, Lund, Sweden. (3) Alligator Bioscience AB, Medicon Village, Scheelevagen 2, 223 81, Lund, Sweden. (4) Alligator Bioscience AB, Medicon Village, Scheelevagen 2, 223 81, Lund, Sweden. (5) Alligator Bioscience AB, Medicon Village, Scheelevagen 2, 223 81, Lund, Sweden. (6) Alligator Bioscience AB, Medicon Village, Scheelevagen 2, 223 81, Lund, Sweden. (7) Alligator Bioscience AB, Medicon Village, Scheelevagen 2, 223 81, Lund, Sweden. (8) Alligator Bioscience AB, Medicon Village, Scheelevagen 2, 223 81, Lund, Sweden. (9) Alligator Bioscience AB, Medicon Village, Scheelevagen 2, 223 81, Lund, Sweden. (10) Alligator Bioscience AB, Medicon Village, Scheelevagen 2, 223 81, Lund, Sweden. (11) Alligator Bioscience AB, Medicon Village, Scheelevagen 2, 223 81, Lund, Sweden. (12) Alligator Bioscience AB, Medicon Village, Scheelevagen 2, 223 81, Lund, Sweden. (13) Alligator Bioscience AB, Medicon Village, Scheelevagen 2, 223 81, Lund, Sweden. (14) Alligator Bioscience AB, Medicon Village, Scheelevagen 2, 223 81, Lund, Sweden. (15) Alligator Bioscience AB, Medicon Village, Scheelevagen 2, 223 81, Lund, Sweden. (16) Alligator Bioscience AB, Medicon Village, Scheelevagen 2, 223 81, Lund, Sweden. (17) Alligator Bioscience AB, Medicon Village, Scheelevagen 2, 223 81, Lund, Sweden. (18) Alligator Bioscience AB, Medicon Village, Scheelevagen 2, 223 81, Lund, Sweden. (19) Alligator Bioscience AB, Medicon Village, Scheelevagen 2, 223 81, Lund, Sweden.

Author Info: (1) Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA. (2) Department of Pathology, University of California, San Francisco, San Franci

Author Info: (1) Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA. (2) Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA. (3) Pionyr Immunotherapeutics, San Francisco, CA 94080, USA. (4) Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA; UCSF Immunoprofiler Initiative, University of California, San Francisco, San Francisco, CA 94143, USA. (5) Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA. (6) Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA; UCSF Immunoprofiler Initiative, University of California, San Francisco, San Francisco, CA 94143, USA. (7) Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA; UCSF Immunoprofiler Initiative, University of California, San Francisco, San Francisco, CA 94143, USA. (8) Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA. (9) Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA. (10) Pionyr Immunotherapeutics, San Francisco, CA 94080, USA. (11) Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA. (12) Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, San Francisco, CA 94143, USA. (13) Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA; UCSF Immunoprofiler Initiative, University of California, San Francisco, San Francisco, CA 94143, USA. (14) Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA. (15) Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, San Francisco, CA 94143, USA. (16) Institute of Human Genetics, University of California, San Francisco, San Francisco, CA 94143, USA. (17) Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA. (18) Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA; UCSF Immunoprofiler Initiative, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: matthew.krummel@ucsf.edu.

Author Info: (1) Department of Hematology/Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York

Author Info: (1) Department of Hematology/Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. (2) Department of Hematology/Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. (3) Department of Hematology/Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. (4) Department of Hematology/Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. (5) Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. (6) Department of Pathology, Molecular and Cell Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. (7) Department of Pathology, Molecular and Cell Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. (8) Department of Hematology/Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. (9) Celldex Therapeutics, Inc., Needham, MA, USA. (10) Celldex Therapeutics, Inc., Needham, MA, USA. (11) Oncovir, Inc, Washington, DC, USA. (12) Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. (13) Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. (14) Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, York, NY, USA. (15) Department of Hematology/Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. joshua.brody@mssm.edu. Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. joshua.brody@mssm.edu.

Author Info: (1) Institute for Molecular Engineering, University of Chicago, Chicago, IL 60637, USA. (2) Institute for Molecular Engineering, University of Chicago, Chicago, IL 60637, USA. (3)

Author Info: (1) Institute for Molecular Engineering, University of Chicago, Chicago, IL 60637, USA. (2) Institute for Molecular Engineering, University of Chicago, Chicago, IL 60637, USA. (3) Institute for Molecular Engineering, University of Chicago, Chicago, IL 60637, USA. (4) Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL 60637, USA. (5) Institute for Molecular Engineering, University of Chicago, Chicago, IL 60637, USA. (6) Department of Pathology, University of Tokyo, 113-8655 Tokyo, Japan. (7) Department of Pathology, University of Tokyo, 113-8655 Tokyo, Japan. (8) Institute for Molecular Engineering, University of Chicago, Chicago, IL 60637, USA. Institute of Bioengineering, Ecole Polytechnique Federale de Lausanne, CH-1015 Lausanne, Switzerland. (9) Institute for Molecular Engineering, University of Chicago, Chicago, IL 60637, USA. (10) Institute for Molecular Engineering, University of Chicago, Chicago, IL 60637, USA. (11) Institute for Molecular Engineering, University of Chicago, Chicago, IL 60637, USA. (12) Institute for Molecular Engineering, University of Chicago, Chicago, IL 60637, USA. (13) Institute for Molecular Engineering, University of Chicago, Chicago, IL 60637, USA. (14) Institute for Molecular Engineering, University of Chicago, Chicago, IL 60637, USA. (15) Department of Pathology, University of Tokyo, 113-8655 Tokyo, Japan. (16) Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL 60637, USA. (17) Institute for Molecular Engineering, University of Chicago, Chicago, IL 60637, USA. Ben May Department for Cancer Research, University of Chicago, Chicago, IL 60637, USA. (18) Institute for Molecular Engineering, University of Chicago, Chicago, IL 60637, USA. jhubbell@uchicago.edu.

Author Info: (1) Department of Obstetrics and Gynecology, Center for Gynecological Oncology Amsterdam (CGOA), Amsterdam UMC, Cancer Center Amsterdam, Vrije Universiteit Amsterdam, Amsterdam, Th

Author Info: (1) Department of Obstetrics and Gynecology, Center for Gynecological Oncology Amsterdam (CGOA), Amsterdam UMC, Cancer Center Amsterdam, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. (2) Department of Medical Oncology, Amsterdam UMC, Cancer Center Amsterdam, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands. (3) Department of Obstetrics and Gynecology, Center for Gynecological Oncology Amsterdam (CGOA), Amsterdam UMC, Cancer Center Amsterdam, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. (4) Department of Medical Oncology, Amsterdam UMC, Cancer Center Amsterdam, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands. (5) Department of Medical Oncology, Amsterdam UMC, Cancer Center Amsterdam, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands. TD.deGruijl@vumc.nl.