Salmon et al. thoroughly review factors in tissue-specific microenvironments that may influence tumor development and immune response across disease sites. These factors include the composition and functional state of tissue-resident non-immune cells (such as cancer-associated fibroblasts) and immune cells (such as macrophages); tumor-infiltrating immune cells; tertiary lymphoid structures; vascular features; nerve cell infiltration; tissue-specific antigenic profile; and the local microbiome. These factors can dramatically impact patient survival and must be considered when designing immunotherapeutic strategies for cancer.
Although common evolutionary principles drive the growth of cancer cells regardless of the tissue of origin, the microenvironment in which tumours arise substantially differs across various organ sites. Recent studies have established that, in addition to cell-intrinsic effects, tumour growth regulation also depends on local cues driven by tissue environmental factors. In this Review, we discuss how tissue-specific determinants might influence tumour development and argue that unravelling the tissue-specific contribution to tumour immunity should help the development of precise immunotherapeutic strategies for patients with cancer.
Author Info: (1) Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. helene.salmon@curie.fr. Precision Immunology Institute and Tisch Cancer Institut
Author Info: (1) Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. helene.salmon@curie.fr. Precision Immunology Institute and Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. helene.salmon@curie.fr. INSERM U932, Institut Curie, Paris, France. helene.salmon@curie.fr. (2) Innate Pharma, Marseille, France. (3) Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Precision Immunology Institute and Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Department of Hematology and Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. (4) Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. miriam.merad@mssm.edu. Precision Immunology Institute and Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. miriam.merad@mssm.edu.
