In the Spotlight...

A bispecific antibody-drug conjugate targeting EGFR and HER3 in metastatic esophageal squamous cell carcinoma: a phase 1b trial

In a phase 1b trial, 82 patients with esophageal squamous cell carcinoma were treated with an anti-EGFR/HER3 bispecific antibody linked to a topoisomerase I inhibitor, at 2.0 or 2.5 mg/kg q3wks. Treat...

CD4+ T cells license Kupffer cells to reverse CD8+ T cell dysfunction induced by hepatocellular priming

Venzin and Beccaria et al. demonstrate that pre-activated CD4+ T cells actively license local hepatic APCs and restore antiviral CD8+ T cell function. HBV-specific CD4+ T cell receptor transgenic mice...

Multimodal delineation of a layer of effector function among exhausted CD8 T cells in tumors

Ray et al. discovered that Cd69 mRNA levels could be used to differentiate between potent and dysfunctional activation states among intratumoral CD69+CD8+ T cells. CD8 T cells with high Cd69 mRNA and ...

IGM-7354, an immunocytokine with IL-15 fused to an anti-PD-L1 IgM, induces NK and CD8+ T cell-mediated cytotoxicity of PD-L1 positive tumor cells

Desbois et al. generated IGM-7354, an IgM comprising ten PD-L1 binding sites which blocked PD-L1/PD-1 binding and a single IL15/IL15Rα complex which activated IL15Rβγ+ human NK and CD8+ T cells and re...

Previous Digests

Vaccine with ICB sidekick unlock anti-melanoma T cell immunity

July 16, 2025

While personalized neoantigen vaccines have great potential, T cell responses induced by these vaccines often lack strength. Blass, Keskin, et al. aimed to improve T cell antitumor immunity by optimizing vaccine adjuvants and combining the vaccine with ICB. The...

Mutant p53 doesn’t just lose functions - it gains them

July 9, 2025

Mutations in the p53 gene are well known drivers of cancer due to the loss of tumor suppressor functions that are maintained by wild-type p53. However, in recent investigations, Mahat et al. found that a common mutant p53, p53R175H...

CD8s get by without a little help from their friends

July 2, 2025

During acute infections, the primary immune response depends on CD4+ T cells providing help to CD8+ T cells. However, many effector CD8+ T cells (Teff) can respond to pathogens independently of helper responses, but these cells respond poorly to...

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About ACIR

ACIR's mission is to fast-track cancer immunotherapy research by helping researchers stay on top of the new literature in this fast-moving and multifaceted field, fostering their creativity and productivity in bringing us ever closer to curing this deadly disease.

Ed Fritsch

Ed Fritsch

Ute Burkhardt

Ute Burkhardt

Lauren Hitchings

Lauren Hitchings

Gaelle Llambi

Gaelle Llambi

Maartje Wouters

Maartje Wouters

Alex Najibi

Alex Najibi

Katherine J. Turner

Katherine J. Turner

Stan Wolf

Stan Wolf

Paula Hochman

Paula Hochman

Shishir Pant

Shishir Pant

Nathan Suek

Nathan Suek

Morgan Janes

Morgan Janes

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