Fc-optimized anti-CTLA-4 antibodies increase tumor-associated high endothelial venules and sensitize refractory tumors to PD-1 blockade
CD8+ T cell-derived CD40L mediates noncanonical cytotoxicity in CD40-expressing cancer cells
The ACIR team attended the 22nd CIMT Annual Meeting 2025 in Mainz, Germany. This week’s extensive special feature covers select talks from the conference. We have organized the content by topics below. CIMT Lifetime achievement awardRolf Kiessling Keynote addressCornelis...
Pancreatic ductal adenocarcinoma (PDAC) has proven resistant to immunotherapy strategies, in part due to limited tumor mutational burden and T cell infiltration. Besides tumor-specific somatic mutations resulting in neoantigens, cancer cells can also translate genome regions outside of annotated...
Whole tumor vaccines are appealing as immunotherapies, as they contain the complete range of potential tumor antigens. However, tumor cell inactivation methods often degrade important tumor cell structures and antigens, and the immunogenicity of whole tumor cell vaccines is...
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