GLOSSARY

G

• GENCODE #

  An annotated database of transcribed elements in the human genome. Transcripts include protein-coding, long non-coding RNA loci, and alternatively transcribed/spliced variants. GENCODE is a subproject of ENCODE. It is the product of a consortium of research groups managed by the National Human Genome Research Institute.

• Genomic Data Commons (GCD) #

  A data sharing platform that standardizes genomic and clinical data from cancer research programs at the National Cancer Institute (NCI), including The Cancer Genome Atlas (TCGA) and Therapeutically Applicable Research to Generate Effective Therapies (TARGET) data and data from individual researchers. The data is processed and harmonized so that it can be directly compared and used to generate higher level data. GCD aims to enable discoveries regarding the molecular bases of cancer that lead to better patient care.

• Genotype-Tissue Expression Database (GTEx) #

  An open access database and tissue bank for the study of tissue-specific gene expression and regulation. GTEx includes expression levels and genetic variation data from whole-genome, whole-exome, and RNAseq data from deceased adult donors with no evidence of disease. The goal is to use RNA expression levels as quantitative traits to identify genes whose expression is affected by genetic variation.

• gp130 (CD130) #

  Alternative names: IL6ST, IL6R-beta, IL6β, common β chain

  In humans and in mice, gp130 can be found on the surface of: T cells, B cells, NK cells, macrophages/monocytes, stem cells/precursors, granulocytes, endothelial cells, dendritic cells (in mice)

  Associated molecules: CD126, CNF, LIF, Oncostatin M, IL-11R, IL-6, IL-11

  Function: cytokine receptor signal transduction

  Additional information: gp130 is also known as CD130. CD130 forms the signal transduction component of cytokine receptors of the IL-6 receptor family and is often referred to as the common gp130 subunit. CD130 is critical for signal transduction after cytokine binding to receptor binding sites, and transmits signals of IL-6, IL-11, LIF, and CNF.