GLOSSARY

L

• L-selectin (CD62L) #

  Alternative names:

  • Human: LECAM-1, MEL-14, Leu8, TQ1, LAM-1
  • Murine: LECAM-1, Lnhr, Ly-22, Ly-m22, Lyam-1, Lyam1

  In humans and in mice, L-selectin can be found on the surface of: T cells, B cells, NK cells, macrophages/monocytes, granulocytes

  Ligands and associated molecules: CD162, CD34, GlyCAM-1, MAdCAM-1

  Function: cell adhesion

  Additional information: L-selectin is also known as CD62L. By contributing to leukocyte tethering and rolling on activated endothelium, CD62L plays an essential role in lymphocyte homing to peripheral lymph nodes and sites of inflammation. Upon antigen encounter and T cell activation in the lymph nodes, CD62L is shed from the cell surface. T cells can then exit the lymph node, enter circulation, and exert their effector functions.

  In conjunction with other markers, most notably CD45RO or CD45RA, CD62L is used to distinguish T cell differentiation states. CD62L is expressed on naive T cells (T_naive), central memory T cells (T_CM) and stem memory T cells (T_SCM), but not on effector memory T cells (T_EM), or effector memory T cells re-expressing CD45RA (T_EMRA).

• LFA-3 (CD58) #

  In humans, LFA-3 can be found on the surface of: T cells, B cells, dendritic cells, NK cells, macrophages/monocytes, granulocytes, erythrocytes, endothelial cells, epithelial cells

  Ligands: CD2 (LFA-2)

  Function: cell adhesion

  Additional information: LFA-3 is also known as CD58. Binding of CD58 to CD2 facilitates the interaction between antigen-presenting cells and T cells, as well as the interaction between cytotoxic cells and target cells. Stimulation of CD58 results in increased T cell and NK cell activity.

• LRP1 (CD91) #

  Alternative names: APOER, APR, ɑ2M-R, ɑ2MR

  In humans, LRP1 can be found on the surface of: macrophages/monocytes, epithelial cells

  Ligands and associated molecules: RAP, ɑ2M, apoE, Lactoferrin, LDLs

  Function: phagocytosis, intracellular signaling, lipid homoeostasis

  Additional information: LRP1 is also known as CD91. CD91 is important for receptor mediated endocytosis. CD91 mediates the phagocytosis and degradation of apoptotic cells and other ligands.