CD Markers
Search our extensive database of CD Markers.
CD102 (ICAM-2) #
Alternative names: ICAM-2, LY-60
In humans and in mice, CD102 can be found on the surface of: T cells, B cells, macrophages/monocytes, endothelial cells
Ligands and associated molecules: LFA-1, CD11b/CD18, Integrin ɑLβ2, MAC-1
Function: cell adhesion, costimulation, lymphocyte recirculation
Additional information: CD102 facilitates the interaction between T cells and B cells during lymphocyte development. CD102 mediates the cell adhesive interactions necessary for an antigen-specific immune response, and other cellular interactions important for immune surveillance and response.
CD103 #
Alternative names: HML-1, Integrin ɑE, ITGAE, OX62, HML1
In humans and in mice, CD103 can be found on the surface of: T cells, some dendritic cells
Ligands: E-Cadherin, Integrin β7
Function: CD8+ T cell homing, cell adhesion
Additional information: The integrin CD103 helps antigen-specific CD8+ T cells enter and remain in epithelial compartments. Marker for effector memory and regulatory T cells or CD11chigh/MHC class IIhigh dendritic cells that reside within the epithelium of mucosal organs.
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CD107a #
Alternative names: LAMP-1, LAMPA, LGP120
CD107a can be found on the surface of:
- Human: T cells, granulocytes, platelets, endothelial cells
- Murine: T cells, B cells, macrophages/monocytes
Ligands: selectins, collagen, laminin, fibronectin
Function: degranulation marker on lymphocytes, cell adhesion
Additional information: CD107a is typically expressed on the surface of lytic granules that store cytotoxic proteins in the cytoplasm of cytotoxic cells such as CD8+ T cells and NK cells. Upon cytotoxic cell activation, the exocytosis of the apoptosis-inducing proteins results in cell surface expression of CD107a. Cell surface expression of CD107a allows selectin binding, facilitating cell adhesion to the extracellular matrix, and cell migration. Cell surface expression of CD107a has been associated with high metastatic potential of cancer cells.
CD112 #
Alternative names: PVRL2, PRR2, Nectin-2, Herpesvirus entry mediator B (HveB)
In humans and in mice, CD112 can be found on the surface of: macrophages/monocytes, stem cells/precursors, platelets, endothelial cells, epithelial cells
Ligands and associated molecules: CD226, Nection-3, Afadin, PRR3
Function: Cell adhesion to the cytoskeleton, intracellular adhesion
Additional information: CD112 is a glycoprotein and one of the structural components of adherens junctions, linking cells to the extracellular matrix or to other cells in epithelial and endothelial tissues. CD112 also acts as a receptor for the herpes simplex virus and allows for viral spread between cells.
CD122 (IL-2Rβ) #
Alternative names: p70-75, IL-2 and IL-15 receptor β chain
In humans and in mice, CD122 can be found on the surface of: T cells, B cells, NK cells, macrophages/monocytes
Ligands: IL-2, IL-15
Associated molecules: CD25, CD132, Syk, Lck, Jak1, Stat5
Function: β subunit of the IL-2 and IL-15 receptor, Signal transduction
Additional information: CD122 is the beta subunit of the IL-2 receptor and IL-15 receptor. Both IL-2 and IL-15 are critical cytokines in the signaling pathways that lead to naive and memory T cell development and effector functions. Recent research has focused on blocking CD122 to promote immune tolerance to transplants. The CD122/IL-15 and CD122/IL-2 pathways play a definitive role in inducing NK cell maturation and maintaining NK cell cytotoxic activity against infection. CD122 expression is upregulated on the surface of NK cell progenitors in preparation for differentiation/maturation.
CD123 (IL-3RA) #
Alternative names: IL3R, IL3RAY, IL3RX, IL3RY, MGC34174, hIL-3Ra
In humans and in mice, CD123 can be found on the surface of: dendritic cells, endothelial cells, granulocytes, macrophages/monocytes, stem cells/precursors
Ligands: IL-3
Associated molecules: CD131
Function: Interleukin-3 receptor
Additional information: CD123 is the IL-3-specific alpha subunit of the IL-3 receptor and forms a complex with CD131 (the common beta chain). IL-3 signals through the heterodimeric IL-3 receptor complex and stimulates proliferation and differentiation.
CD124 (IL-4 receptor ɑ chain) #
Alternative names: IL4RA, IL4R
CD124 can be found on the surface of:
- Human: T cells, B cells, stem cells/precursors, macrophages/monocytes, epithelial cells
- Murine: T cells, B cells, dendritic cells, granulocytes, epithelial cells
Ligands: IL-4, IL-13
Associated molecules: CD132, Jak1, Fes, Stat6, IRS-2
Function: Interleukin-4 and Interleukin-13 receptor
Additional information: CD124 is the alpha chain of the IL-4 and IL-13 receptors. CD124 interacts with CD132 to form a functional receptor. IL-4 or IL-13 signaling pathways are important for IgE production, differentiation of Th2 cells, alternative activation of B cells, and the regulation of CD20 levels on B cells.
CD127 (IL-7Rα) #
Alternative names: p90
In humans and mice, CD127 can be found on the surface of: T cells, precursor cells, macrophages/monocytes
Function: receptor for IL-7 and thymic stromal lymphopoietin (TSP), T cell maturation and proliferation.
Ligands: IL-7, TSLP
Associated molecules: CD132, Fyn, lyn, Jak1, P13-Kinase, Lck
Additional information: CD127, together with CD132, forms the IL-7 receptor. Binding of IL-7 to the IL-7 receptor causes a signal cascade that stimulates the first stage of thymic T cell development by protecting from apoptosis and promoting VDJ TCR recombination. CD127 signaling is crucial for the survival of mature T cells within the periphery. CD127 transcription and expression is homeostatically controlled in a negative feedback loop by IL-7 levels. CD127, together with the TSLP receptor chain (TSLPR or CRLF2), forms a high-affinity receptor for TSLP, which plays a pivotal role in T cell maturation, promoting T cell proliferation, driving T helper cytokine production, and inducing dendritic cell polarization.
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CD130 (gp130) #
Alternative names: IL6ST, IL6R-beta, IL6β, common β chain
In humans and in mice, CD130 can be found on the surface of: T cells, B cells, NK cells, macrophages/monocytes, stem cells/precursors, granulocytes, endothelial cells, dendritic cells (in mice)
Associated molecules: CD126, CNF, LIF, Oncostatin M, IL-11R, IL-6, IL-11
Function: cytokine receptor signal transduction
Additional information: CD130 forms the signal transduction component of cytokine receptors of the IL-6 receptor family and is often referred to as the common gp130 subunit. CD130 is critical for signal transduction after cytokine binding to receptor binding sites, and transmits signals of IL-6, IL-11, LIF, and CNF.
CD132 (Common γ chain) #
Alternative names: cytokine receptor common γ chain, IL2RG/IL2Rγ, γc
CD132 can be found on the surface of:
- Human: T cells, B cells, NK cells, macrophages/monocytes, granulocytes
- Murine: T cells, B cells, dendritic cells, macrophages/monocytes
Associated molecules: Subunit of IL-2, IL-4, IL-7, IL-9, IL-15, IL-21 receptors; CD25, CD122, CD124, CD127, CD129, CD360, JAK3, JAK1, syk, ick
Function: functional cytokine receptor formation, signal transduction
Additional information: CD132 forms with other ligand-specific receptor molecules, such as CD25, CD122, CD124, CD127, CD129, and CD360 functional interleukin receptors, which play a critical role for intercellular communication. Upon cytokine binding, the JAK/STAT signaling pathway is triggered, eventually activating transcription factors that drive cell outcomes, such as lymphocyte differentiation, maturation, and proliferation.
Further reading:
CD150 #
Alternative names: SLAMF1, IPO-3, SLAM, ESTM51
In humans and in mice, CD150 can be found on the surface of: T cells, B cells, dendritic cells, endothelial cells, granulocytes (in mice)
Ligands in human: CD45, homodimer with CD150, measles virus
Associated molecules: SH2D1A/SAP, SH2D1B/EAT-2, PTPN11
Function: costimulation, immune cell activation, cell signaling
Additional information: CD150 is part of the signaling lymphocytic activation molecule (SLAM) family. CD150 activity is controlled by small adapter molecules SH2D1A, SH2D1B, and PTPN11. During an immune response, CD150 mediates IL-2-independent proliferation and IFNγ production of activated T cells.
