CD Markers
Search our extensive database of CD Markers.
CD314 (NKG2D) #
Alternative names: KLRK1
In humans and in mice, CD314 can be found on the surface of: T cells, B cells, NK cells, macrophages/monocytes, granulocytes
Ligands: MICA, MICB, ULBP2, ULBP1, H60 (mice)
Associated molecules: DAP10 dimer or DAP10 and DAP12 (in mice)
Function: MHC-1 HLA-E molecule recognition, NK cell activation
Additional information: CD314 (NKG2D) is a key activating receptor on NK cells. CD314 is also a costimulatory molecule on T cells and promotes the development of memory CD8+ T cells. CD314 expression on the surface of B cells plays a key role in B cell proliferation and differentiation and the regulation of IgE production. Ligands of CD314 are homologous to MHC class I molecules, and come from the MIC or RAET1/ULBP family. The expression of NKG2D ligands is induced during cellular stress (e.g., infection, senescence) or genomic stress (e.g., mutations, increased proliferation, viral replication).
CD317 (Tetherin) #
Alternative names: BST2
In humans and in mice, CD327 can be found on the surface of: T cells, B cells, NK cells, dendritic cells, macrophages/monocytes
Ligands: Mature virions
Function: prevention of viral spreading
Additional information: CD317 plays a role in the IFN-induced antiviral response, and tethers mature virions to the surface of the host cell to prevent diffusion and spreading of the virus particles after budding from the infected host cell.
CD335 (NKp46) #
Alternative names: Ly-94, NCR1
In humans and in mice, CD335 can be found on the surface of: NK cells
Ligands: Viral glycoproteins (hemagglutinins), Heparan sulfate proteoglycans
Associated molecules: CD3ζ and FcεRIγ
Function: NK cell cytotoxicity, NK cell activation
Additional information: CD335 is part of the natural cytotoxicity receptor (NCR) family. CD335 plays a role in antitumor and antiviral immunity, conferring tumor cell recognition and binding of viral hemagglutinins. Engagement of CD335 on NK cells results in increased cytokine production and cytotoxicity. CD335 is expressed on the surface of activated and resting NK cells.
CD336 (NKp44) #
Alternative names: Ly-95, NCR2
In humans, CD336 can be found on the surface of: NK cells
Ligands: viral proteins
Associated molecules: DAP12
Function: mediation of NK cytotoxicity and NK cell activation
Additional information: CD336 is part of the natural cytotoxicity receptor (NCR) family. CD336 is expressed only on the surface of activated NK cells (in contrast to CD335 and CD337). It plays an important role in NK cell cytotoxic activity. CD336 is involved in tumor cell recognition and activating NK cytotoxicity against cancer cells. CD336 associates intracellularly with the DAP12 adaptor proteins.
Further reading:
CD337 (NKp30) #
Alternative names: Ly-117, NCR3
In humans, CD337 can be found on the surface of: NK cells
Ligands: viral proteins, heparan sulfate proteoglycans
Associated molecules: CD3ζ
Function: mediation of NK cytotoxicity and NK cell activation
Additional information: CD337 is part of the natural cytotoxicity receptor family. CD336 is expressed on the surface of activated and resting NK cells. It plays an important activating role in NK cell cytotoxic activity and cytokine production. CD337 interacts with CD3ζ, which is required for signal transduction through the receptor. CD337 can increase NK cell cytotoxicity against cancer cells.
Further reading:
CD353 #
Alternative names: BLAME (B-lymphocyte activator macrophage expressed), SLAMF8
In humans and in mice, CD353 can be found on the surface of: B cells, dendritic cells, macrophages
Function: macrophage regulation, B cell differentiation
Additional information: CD353 may play a role in B cell lineage commitment and modulation of BCR signaling. CD353 is a costimulatory molecule expressed on activated macrophages.
CD354 (TREM-1) #
CD354 can be found on the surface of:
- Human: T cells, B cells, NK cells, dendritic cells, granulocytes, macrophages/monocytes
- Murine: granulocytes, macrophages/monocytes
Associated molecules: DAP12, TLRs
Function: stimulation of the inflammatory response
Additional information: CD354, also known as the triggering receptor expressed on myeloid cells 1 (TREM1), is a member of the immunoglobulin superfamily. CD354 further stimulates neutrophils, monocytes and macrophages in an inflammatory response by increasing the production and release of inflammatory cytokines. CD354 amplifies the inflammatory response induced by Toll-like receptor ligands. CD354 is expressed on monocytic myeloid-derived suppressor cells (mMDSC), tumor-associated macrophages (TAMs), and tumor-associated neutrophils (TANs), and is studied as a target in cancer immunotherapy.
CD355 #
Alternative names: Cytotoxic and regulatory T cell molecule (CRTAM)
CD355 can be found on the surface of:
- Human: T cells, B cells, NK cells
- Murine: T cells, NK cells, epithelial cells
Ligands: CADM1
Function: activation/regulation of immune response, cell adhesion
Additional information: Upon interacting with CADM1, CD355 promotes NK cell cytotoxicity and prompts CD8+ T cell activation, proliferation, and IFNγ secretion. Interactions between CD355 on activated CD8+ T cells and CADM1 on CD8+ dendritic cells, regulates retention of T cells in the draining lymph node. T cell retention in the intestine or gut also requires CD355 and CADM1 interaction.
Further reading:
CD360 (IL-21R) #
CD360 can be found on the surface of:
- Human: T cells, B cells, NK cells, dendritic cells, granulocytes, macrophages/monocytes, stem cells
- Murine: T cells, B cells
Ligands: IL-21
Associated molecules: CD132, JAK-1, JAK-3 and STAT
Function: Receptor for IL-21
Additional information: CD360 is a type I cytokine receptor and forms a receptor complex with the common gamma chain cytokine receptor subunit (CD132). Binding of IL-21 activates the Janus-kinase pathway and downstream, the STAT signaling pathway. The IL-21/IL-21R pathway is crucial for increasing T cell differentiation and proliferation, NK cell differentiation and cytotoxicity, and differentiating B cells into antigen-specific memory B cells.
