2026
June
Unraveling the role of CCR1 in tumor myeloid cells
June 10, 2026
Pancreatic cancer (PDA) is a highly resistant and difficult-to-treat tumor type, often marked by extensive fibroinflammatory stroma and infiltration of immunosuppressive myeloid cells. These myeloid cells, including macrophages and granulocytes, have been noted to have high expression of CCR1, though the role of this chemokine receptor has not been thoroughly studied. In recent...
AI reads between the sequences to decode TCR specificity
June 3, 2026
Predicting TCR recognition from sequence alone is challenging because TCRs with low sequence similarity may bind the same peptide–MHC (pMHC), whereas nearly identical TCR sequences may bind different pMHCs. Wang, Yeh, et al. developed a new approach to map TCR recognition using high-throughput yeast display and protein language models (pLMs). Their work was...
