Weekly Digests

2026

July

Tregs versus Tconv: a battle over metastasis in PDAC

July 8, 2026

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and difficult-to-treat-tumor type with complex immune dynamics and multiple immune evasion mechanisms at different stages of disease. In work recently published in Science Immunology, Schmiechen et al. unraveled the roles of IFNγ-inducible MHC-I, CD8+ T cells, Tregs, and conventional CD4+ T cells (Tconv) in promoting or...

Exhausted, yet effective: Eomes drives Th-mediated antitumor responses

July 1, 2026

While accumulating evidence suggests an important role for CD4+ T cells in antitumor immunity, the specific subpopulations responsible remain to be defined. Agesta, Ferrand, et al. investigated the function of the transcription factor Eomes in CD4+ T cell antitumor responses, and identified Eomes-responsive antitumor Th populations, with significant analogies to similar Eomes-responsive CD8+...

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