In situ programming of leukaemia-specific T cells using synthetic DNA nanocarriers
April 26, 2017
In a new approach to CAR T cell engineering, Smith et al. skip the petri dish and head straight to the mouse. Using a stable, easy-to-manufacture nanoparticle gene delivery system, circulating T cells can be quickly programmed in vivo with CD19-targeted CARs. The nanoparticles were designed to contain two co-encapsulated DNA plasmids, one...
Landscape of Immunogenic tumor antigens in successful immunotherapy of virally induced epithelial cancer
April 19, 2017
Any good scientist knows that correlation does not necessarily equal causation. So, when two patients experienced complete remission of HPV-associated cervical cancer following adoptive therapy with tumor-infiltrating lymphocytes (TILs) that were selected for HPV reactivity, Stevanović et al. dug deeper to challenge the notion that a T cell response against the viral antigens...