Weekly Digests



Stem-immunity hubs predict response to anti-PD-1 in NSCLC

March 27, 2024

Chen, Nieman, and Spurrell et al. recently evaluated multicellular “immunity hubs” in samples of human non-small cell lung cancer (NSCLC) taken prior to treatment with anti-PD-1. Using imaging techniques and spatial transcriptomics, the researchers identified and characterized novel “stem-immunity hubs” that were strongly associated with PD-1 blockade responses and outcomes. Their results were...

T cells and macrophages collaborate to overcome MHC-I loss-induced immune deserts

March 20, 2024

Loss of MHC class I expression on tumor cells is a frequently observed immunotherapy resistance mechanism. The increased use of immune checkpoint blockade (ICB) for the treatment of solid tumors has resulted in more therapy-resistant MHC-I-deficient tumors. To better understand the mechanisms behind these effects and determine how to overcome this response, Beck...

CD4+ T cells help cDC1s provide CD8+ T cells with a license to kill

March 13, 2024

CD4+ T helper cells can stimulate CD8+ T cell responses by interacting with dendritic cells (DCs) through a process termed “DC licensing”. The conventional type 1 DC (cDC1) subset has been identified as the essential DC subtype for this process. Lei et al. investigated the mechanism of cDC1 licensing in human cells and...

ESMO Targeted Anticancer Therapies Congress 2024

March 6, 2024

The ACIR team attended the ESMO Targeted Anticancer Therapies Congress 2024 in Paris, France. This week’s extensive special feature covers select talks from the conference. We have organized the content by topics below. Keynote lecture on tumor neoantigensYardena Samuels BispecificsJuanita S. LopezShohei KoideGeorg Falck Antibody-drug conjugatesTakashi KagariGiuseppe CuriglianoBarbara PistilliToshio Shimizu Targeted interleukinsGiuseppe CuriglianoIgnacio...

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