Weekly Digests

2025

January

What really happens when you block TIGIT and PD-L1 together

January 8, 2025

Both PD-1 and TIGIT are checkpoint molecules known to inhibit the antitumor effects of CD8+ T cells, and blocking them in combination has been shown to have synergistic immunotherapeutic effects. However, the exact mechanism and dynamics of this synergy are incompletely understood. In recent research, Nutsch, Banta, and Wu et al. utilized a...

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