Weekly Digests

2019

October

Effector or Exhausted: TCF-1 Seals T cell Fate

October 16, 2019

CD8+ T cell exhaustion plays a major role in chronic immune responses to both infection and cancer and is a major target of immunotherapy. To understand how and when exhaustion programs are initiated, Chen and Ji et al. analyzed gene expression data and transcription factor activity to define a binary fate decision early...

Anti-CTLA-4 relies on RIG-I for tumor control

October 9, 2019

Aiming to improve the consistency of response to checkpoint inhibitors, Heidegger and Wintges et al. explored how the signaling of RIG-I – a cytosolic sensor that detects double-stranded RNA during bacterial or viral infection – contributes to IFN-I production within the tumor microenvironment, and how it affects the antitumor immunity mediated by immune...

CICON19 - 5th CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference

October 2, 2019

Last week, the ACIR team attended the Fifth CRI-CIMT-EATI-AACR International Cancer Immunotherapy conference in Paris, France. This week’s extensive special feature covers select talks from the conference, which are organized by the topics below. Targeting the PD-1 axis Vaccination approachesCARs targeting solid tumors or the tumor stromaTumor and the microenvironmentMicrobiota-immune interactionsBiology of innate...

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