2025
October
CRISPR screens to level up CAR-T therapy
October 8, 2025
One of the major questions in CAR T cell therapy research is how to improve CAR-T expansion, persistence, and functionality to improve clinical responses and prevent relapses. Two recent back-to-back publications in Nature used CRISPR screening methods to detect genetic targets for improving CAR-T therapy. In the first paper, Knudson, Escobar, Korrell, et...
CAR T cells take TROP2 targeting to the next level
October 1, 2025
TROP2 is a fetal oncogene that is expressed in a number of cancer types, and while it can be successfully targeted by antibody–drug conjugates (ADCs), cancer cells often develop ADC resistance, either through loss of expression of the targeted TROP2 epitope, or acquired resistance to the drug payload. In an effort to more...
