2024
September
Age is more than just a number in cancer immunotherapy
September 11, 2024
Age-related changes to the immune system contribute to increased cancer progression and resistance to immunotherapy in older patients. Investigating this, Georgiev and Han et al. recently found that tumors grew more rapidly in aged mice due to impaired cytotoxic CD8+ T cell activation and effector differentiation within tumors, and a loss of tumor...
New insights into how tumor gene expression editing leads to immune evasion
September 4, 2024
Gene expression editing in tumor cells results in evasion of immunosurveillance, but the exact edited genes and their relationship to the immune response have not been studied in detail. Using a genetically engineered breast cancer model, Zhang, Naderi Yeganeh, et al. identified edited genes related to the immune response, and evaluated a therapeutic...
