2024
September
A sweet spot in the spleen for immune checkpoint blockade responses
September 25, 2024
Immune checkpoint blockade unleashes powerful antitumor T cell responses, but exactly which T cell states are involved and from which anatomic locations they emerge are not fully understood. Investigating these topics, Morgan, Horton, Bhandarkar, et al. profiled T cells across tumors, lymph nodes, and spleens in tumor-bearing mice, and identified an intermediate-exhausted T...
Flipping the script: reprogramming tumor cells into DCs
September 18, 2024
Type 1 conventional dendritic cells (cDC1s) are required for T cell-mediated tumor regression and response to immune checkpoint blockade (ICB) in cancer. However, current immunotherapy strategies are not focused on exploiting key aspects of cDC1 functionality in vivo, such as chemokine secretion and antigen cross-presentation. In a recent Science publication, Ascic et al...
Age is more than just a number in cancer immunotherapy
September 11, 2024
Age-related changes to the immune system contribute to increased cancer progression and resistance to immunotherapy in older patients. Investigating this, Georgiev and Han et al. recently found that tumors grew more rapidly in aged mice due to impaired cytotoxic CD8+ T cell activation and effector differentiation within tumors, and a loss of tumor...
New insights into how tumor gene expression editing leads to immune evasion
September 4, 2024
Gene expression editing in tumor cells results in evasion of immunosurveillance, but the exact edited genes and their relationship to the immune response have not been studied in detail. Using a genetically engineered breast cancer model, Zhang, Naderi Yeganeh, et al. identified edited genes related to the immune response, and evaluated a therapeutic...
