Checkpoint receptors - unexpectedly essential for forming memory T cells
January 27, 2021
Even though the importance of forming long-lived memory CD8+ T cells is widely acknowledged, the origin of this T cell subset remains largely unknown. Johnnidis and Muroyama et al. used a well established viral infection model to phenotype and functionally characterize the cell subsets responsible for memory formation and recall responses, and uncovered...
Make it a double: bispecific antibodies targeting PD-1 and CTLA-4
January 20, 2021
Dual blockade of PD-1 and CTLA-4 checkpoint molecules using monoclonal antibodies has taken advantage of their distinct and complementary mechanisms to enhance clinical responses over monotherapies. However, many patients still fail to respond, and over half of patients experience severe treatment-related adverse events. To improve upon these outcomes, researchers have investigated bispecific targeting...
Focus on suppressive macrophages may boost effects of PARP inhibitors
January 13, 2021
Even though FDA-approved poly(ADP-ribose) polymerase inhibition (PARPi) can be very effective in BRCA-mutant breast cancer, responses are not durable, prompting a need for combination therapies. To provide a mechanistic basis for considering immunotherapeutic strategies, Mehta et al. used high-dimensional single-cell and multi-omics profiling in patient samples and in mouse models to study changes...