Weekly Digests

2018

November

Stress and metabolism in the cancer-exposed T cell

November 14, 2018

Tumors create a hostile microenvironment that disrupts T cell metabolism and effector function and allows for tumor progression, but the specific pathways between the environmental stressors and the disruption of T cell metabolic function are not fully understood. In a letter recently published in Nature, Song et al. investigated this mechanism in the...

Macrophages swallow tumor cells to protect cancer from immune response

November 7, 2018

In a recent paper published in Cell, Su, Zhao, and Xing et al. explored the effect of antibody-dependent cellular phagocytosis (ADCP) on tumors and unexpectedly discovered that following monoclonal antibody treatment, ADCP in macrophages led to suppression of natural killer (NK) and T cells as well as poor antitumor response in breast cancers...