Weekly Digests

2024

February

Antigen-specific T cells in blood predict anti-PD-1 responses in Merkel cell carcinoma

February 14, 2024

Tumor antigen-specific CD8+ T cells are known to be important in antitumor immunity, but identifying them in patient samples is often a challenge. In order to study tumor antigen-specific CD8+ T cell as potential biomarkers of response, two groups, Pulliam and Jani et al. and Ryu et al., recently evaluated them in Merkel...

Adding a personalized neoantigen vaccine to checkpoint blockade keeps resected melanoma away in a phase IIb trial

February 7, 2024

Following surgical resection of high-risk cutaneous melanoma, patients are generally treated with checkpoint inhibitors to prevent tumor recurrence, but a high proportion of patients still recur within 5 years. In an effort to reduce these recurrence rates, Weber et al. evaluated the addition of adjuvant personalized neoantigen vaccines (mRNA-4157) in a phase IIb...

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