Weekly Digests

2018

October

Tumors get cozy in the LAP of macrophages

October 17, 2018

In the early stages of tumor development, the process of autophagy (degradation of intracellular components) protects against the emergence of malignant cells; however, in more established cancers, autophagy can promote tumor progression by supplying the tumor cells with necessary nutrients. Inspired by this duality, Cunha et al. explored non-canonical roles of autophagy components...

Fourth CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference: Translating Science into Survival

October 10, 2018

Last week, the ACIR team attended the Fourth CRI-CIMT-EATI-AACR International Cancer Immunotherapy conference in New York. This week’s extensive special feature covers select talks from the conference, which are organized by topics below. Resistance Mechanisms and Combination StrategiesIdentifying Relevant Neoantigens and TCRsCAR T cells and Adoptive Cell TransferVaccinesMicrobiome Resistance Mechanisms and Combination Strategies...

NKILA: A matter of (T cell) life and (activation-induced cell) death

October 3, 2018

Activation-induced cell death (AICD) is part of the immune system’s important checks and balances, but as with multiple other regulatory pathways, tumors can co-opt T cell AICD as a mechanism of immune escape. To better understand how tumors induce AICD and which immune cells are targeted, Huang et al. performed an in-depth discovery...