2025
September
All about CICON25!
September 24, 2025
The ACIR team attended the CRI-ENCI Ninth International Cancer Immunotherapy Conference (CICON) 2025 in Utrecht, The Netherlands. This week’s extensive special feature covers select talks from the conference. We have organized the content by topics below. Keynote addressMichel Sadelain William B. Coley Award LectureAviv Regev Tumor immune microenvironment Dmitry Gabrilovich Tanja de Gruijl...
Stressed out telomeres drive T cell malfunction
September 17, 2025
Tumor-infiltrating T cells are known to lose functionality in the tumor microenvironment and become dysfunctional or terminally exhausted, limiting antitumor immunity and immunotherapy responses. The drivers behind this process remain largely to be determined. Rivadeneira et al. investigated the role of oxidative stress in T cell function. Their results were recently published in...
Tired out T cells: aberrant glycosylation drives T cell exhaustion in early tumors
September 3, 2025
Changes in glycosylation are a hallmark of cancer, and recent work has suggested that branched N-glycans on T cells may play a role in limiting their antitumor activity. In recent work, Azevedo et al. investigated the T cell glycome within tumors to better understand whether and how expression of aberrant glycans on T...
