2024
April
Personalized neoantigen vaccine improves anti-PD-1 in advanced hepatocellular carcinoma in early clinical trial
April 24, 2024
Advanced hepatocellular carcinoma (HCC) is a tumor type with a modest tumor mutation burden (TMB), low T cell infiltration, limited responses to checkpoint inhibitors, and a low patient survival rate. To overcome these hurdles, Yarchoan et al. conducted a single-arm, open-label, phase 1/2 study, in which 36 patients with advanced HCC who had...
AACR Annual Meeting 2024
April 17, 2024
Last week, the ACIR team attended the AACR Annual Meeting 2024 in San Diego, California. This week’s extensive special feature covers select talks from the conference. We have organized the content by topics below. AACR-Cancer Research Institute Lloyd J. Old AwardGordon J. Freeman Regulation of anti-tumor immunitySébastien TalbotStefani SprangerDmitry I. GabrilovichJustin Micah BalkoSjoerd...
KEYSTONE SYMPOSIA: Beyond Immune Checkpoint Blockade and Overcoming Resistance
April 10, 2024
The ACIR team attended the Keystone Symposia on Cancer Immunotherapy: Beyond Immune Checkpoint Blockade and Overcoming Resistance held on March 17-20, 2024 in Whistler, BC, Canada. This week’s extensive special feature covers select talks from the conference. We have organized the content by topics below. (This Keystone Symposia conference is available for On...
Macrophage makeover required for effective CTLA-4 and ICOS combination therapy
April 3, 2024
Having previously shown that ICOS stimulation via an ICOSL-transduced B16F10 cellular vaccine (IVAX) works synergistically with CTLA-4 immune checkpoint blockade (ICB) in various murine tumor models, Sharma et al. set out to explore the mechanism of action of this synergy. In a recent publication in the Journal of Experimental Medicine, they described their...
