Weekly Digests



Cancer escapes before you know it’s there

July 17, 2019

With the goal of detecting and treating cancer as early as possible, Mascaux and Angelova et al. analyzed biopsies of premalignant and malignant lesions from patients who ultimately developed lung squamous cell carcinoma (SCC), and found that immune activation and subsequently immune escape occur in the pre-invasive stages of carcinogenesis. The results were...

Activation and exhaustion in adaptive NK cells

July 10, 2019

It is well known that chronic stimulation of the TCR on T cells leads to activation and exhaustion, but the effect of chronic stimulation on NK cells is not as well understood. To investigate this, Merino et al. induced chronic stimulation in CD3-CD56dimCD57+NKG2C+ NK cells, deemed “adaptive” NK cells, which have a genetic...

TOX is so exhausting!

July 3, 2019

In this special feature, we summarize five recently published papers that explore the role of the transcription factor TOX in exhausted CD8+ T cells, which are common in cancer and chronic infections, and are the major target of checkpoint blockade. Although the research groups utilized different models (acute infection, chronic infection, tumors) and...

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