2025
June
A new off-the-shelf CAR T cell product made from iPSCs
June 11, 2025
CAR T cell therapies are well known for their potent capacity for killing antigen-expressing target cells. However, they are often hindered by factors in solid tumors and by challenges related to the development of an autologous T cell product. In order to overcome these hurdles and improve CAR T cell therapies, Hosking et...
Non-mutated tumor antigens in the spotlight for therapeutic targeting
June 4, 2025
Recent discoveries of unmutated aberrantly expressed tumor-specific antigens (aeTSAs) derived from non-coding regions and embryonic transcriptional programs has garnered attention as targets for immunotherapy. Apavaloaei et al. explored cell surface presentation of peptide:MHCs derived from mutated and unmutated tumor antigens (TAs) in melanoma and non-small cell lung cancer (NSCLC), cancer types with high...
