Weekly Digests

2021

June

A Fountain of Youth for T cell Function

June 16, 2021

With advancing age comes a decrease in immune function, which can also dampen responses to immunotherapy. Investigating this, Nakajima et al. compared T cell subsets, based on their expression of CD44 and CD62L, in young versus aged mice. Among CD8+ T cells, CD44lowCD62Lhigh (P1) cells are defined as naive, CD44highCD62Lhigh (P2) cells are...

IL-10 rejuvenates your exhausted T cells

June 9, 2021

While immunotherapies work great in some patients, for most, results are limited. One reason for the limited therapeutic response is the induction of an “exhausted” phenotype in CD8+ TILs. Aiming to reinvigorate exhausted CD8+ TILs in the TME, Guo and Xie et al. explored the effects of IL-10 treatment and combined it with...

Anti-CD40 agonist antibodies may be the way to go for bladder cancer

June 2, 2021

When patients are diagnosed with non-muscle-invasive bladder cancer, intermediate- to high-risk patients typically undergo transurethral tumor resection, followed by intravesical treatment with Bacille Calmette-Guérin (BCG) as the standard of care. However, up to 75% of patients ultimately become unresponsive to this treatment. Even with the recent approval of anti-PD-1 therapy in the BCG-unresponsive...

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