Weekly Digests

2019

April

The priming power of cDC2s

April 24, 2019

While researchers often focus on CD8+ T cells in antitumor immunity, many studies have shown critical roles for CD4+ T cell responses as well. In order to better understand the context in which antitumor CD4+ T cell responses are initiated, Binnewies and Mujal et al. examined a variety of cell types and factors...

Potassium determines the fate of T cells

April 17, 2019

In a paper recently published in and featured on the cover of Science, Vodnala and Eil et al. investigated why some patients have dysfunctional tumor-infiltrating lymphocytes (TILs), while others have T cells that behave like stem cells in their capacity to self-renew, proliferate, and destroy large tumors. They found that this difference is...

AACR Annual Meeting 2019

April 10, 2019

Last week, the ACIR team attended the AACR Annual Meeting 2019 in Atlanta, Georgia. This week’s extensive special feature covers select talks from the conference. We have organized the content by topics below. T cells in Immune surveillance, Exhaustion, and TherapiesEmerging Immunotherapy ApproachesTME and Tumor EscapeClinical Trials T cells in Immune surveillance, Exhaustion...

Targeting macrophages and neutrophils enhances response to chemotherapy

April 3, 2019

Previous research has shown that the immune system contributes to chemotherapy response; therefore, immunosuppressive mechanisms can be hypothesized to limit the cytotoxic effect. In a study recently published in Nature Cell Biology, Salvagno et al. demonstrated that targeting immunosuppressive macrophages and neutrophils enhances the efficacy of platinum-based chemotherapy in a mouse breast cancer...

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