Weekly Digests



Making the cut: exitrons as a new source of neoantigens

April 28, 2021

Exitrons are internal regions of an exon that have both protein-coding and splicing potential. When these exitrons are spliced, it may lead to protein isoforms, including in-frame deletions, as well as out-of-frame neo open reading frames. As not much is known about the abundance or impact of exitrons in cancer, Wang and Liu...

AACR Annual Meeting 2021

April 21, 2021

Last week, the ACIR team attended the virtual AACR Annual Meeting 2021. This week’s extensive special feature covers select talks from the conference. We have organized the content by topics below. Tumor microenvironment and effective immunotherapySergio QuezadaTheresa KolbenAntoni RibasIra Mellman Combination therapiesTaha MerghoubGeorge Coukos T cell dysfunction and exhaustionE. John WherryAndrea SchietingerDaniela Stefanie...

DCs can TAP out of ordinary cross-presentation

April 14, 2021

Our classic understanding of antigen presentation to CD8+ T cells involves transport of cytosolic peptides into the endoplasmic reticulum (ER) by the transporter associated with antigen processing (TAP), where they can be loaded onto MHC class I molecules through the canonical peptide loading complex. Cross-presentation occurs when extracellular antigens are presented on MHC-I...

Lymphangiogenesis gets vaccine responses back on track

April 7, 2021

Lymphangiogenesis, the growth of lymphatic vessels, has contradictory consequences in cancer; within the tumor, it is associated with metastasis and poor prognosis, but outside of the tumor, it can boost T cell immunity. Using this knowledge, Sasso et al. developed a cancer vaccine strategy to increase tumor control and immune memory. The preclinical...

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