Rethinking the meaning of T cell exhaustion in non-small-cell lung cancer
July 25, 2018
Blockade of the PD-1/PD-L1 axis effectively reverses T cell exhaustion in some instances of cancer, but understanding what defines “exhaustion” and which cells have the potential for reinvigoration will be important in predicting responses, improving efficacy, and broadening the applications of PD-1 checkpoint blockade. To better understand T cell exhaustion in the context...
To maximize immune response, leave the lymph node alone
July 11, 2018
In clinical practice, radiation oncologists frequently perform elective nodal irradiation (ENI) to irradiate clinically uninvolved tumor-draining lymph nodes (TDLN) in addition to the localized tumor in order to preemptively treat potential nodal micrometastases. However, it is unclear how the irradiation of TDLN affects adaptive immune response and the efficacy of radiation therapy in...
Targeting Tregs for inhibition activates enhanced antitumor response
July 5, 2018
Regulatory T cells (Tregs) are frequently found in high quantities in cancers, where a high load of Tregs corresponds to a poor prognosis, but systemic depletion of Tregs can unleash severe autoimmunity. In the search for new ways to safely deplete Treg populations, Wang et al. in their paper published in Cell and...