Weekly Digests

2025

December

IL-9-powered CAR-T for improved solid tumor responses

December 3, 2025

Overcoming immunosuppression in the tumor microenvironment (TME) is a major challenge in CAR T cell research to improve therapeutic efficacy towards solid tumors. To address some of the CAR-T functionality challenges, Castelli et al. engineered CAR T cells with an authentic IL-9 receptor (IL-9R) to enable IL-9 responsiveness. These CAR-T were assessed in...

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