2023
April
AACR Annual Meeting 2023
April 26, 2023
Last week, the ACIR team attended the AACR Annual Meeting 2023 in Orlando, Florida. This week’s extensive special feature covers select talks from the conference. We have organized the content by topics below. Personalized cancer vaccinesJeffrey S. WeberVinod P. BalachandranCatherine J. Wu Tumor immune microenvironment and beyondGabriel A. RabinovichIgnacio MeleroKarin E. de VisserFlorencia...
NKp46 finds its ligand in ecto-CRT on stressed and senescent cells
April 19, 2023
Natural killer (NK) cells are known for their ability to recognize and kill targets that are transformed, infected, stressed out, or senescent, and while NK cells are known to act through several NK cell receptors, many of the ligands that activate those receptors have remained elusive. In a recent study published in Nature...
Masking bispecific T cell engagers until they reach the tumor improves their toxicity profile
April 12, 2023
Bispecific T cell engagers (TCE) targeting tumor-associated antigens (TAA) that are expressed at low levels in healthy tissues can cause significant toxicity due to on-target, off-tumor immune effects. To overcome this issue, Cattaruzza et al. developed a protease-releasable masking technology that allows for the creation of precision-activated TCEs (XPAT proteins) that are unmasked...
Neutrophils help to clear including antigen escape variants in tumors
April 5, 2023
In a previous study, the combination of cyclophosphamide (CTX), CD4+ T cells specific for the melanoma antigen Trp1 (Trp1 T cells), and an anti-OX40 agonist antibody cleared advanced mouse melanoma tumors, including tumor cells that did not express the Trp1 target antigen. Investigating this interesting phenomenon, Hirschhorn et al. found that while T...
