Weekly Digests

2020

October

A new internal T cell checkpoint: CISH

October 14, 2020

PD-1 and other known markers of activation and exhaustion have helped researchers to understand T cell biology and develop numerous immunotherapies. While many of these markers are well known and well studied, there are likely more that have yet to be investigated. Looking into the relationship between PD-1 and other markers of activation...

PD-L1 and PD-1 mediate T cell suppression, but not where you think

October 7, 2020

Targeting the PD-1/PD-L1 axis is a common immunotherapeutic strategy that works well in some, but not all patients with cancer. Typically, researchers have looked at interactions between PD-1 and PD-L1 within tumors to explain the mechanism behind this treatment; however, this has never fully explained the efficacy, or lack thereof, of PD-1/PD-L1 blockade...

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