Weekly Digests

2018

August

Anti-PD-L1 unleashes the power of the macrophage

August 15, 2018

In a paper recently published in Cancer Immunology Research, Hartley et al. set out to explore how PD-L1 signaling affects the function of tumor-associated macrophages (TAMs), and in the process they discovered that PD-L1 blockade and PD-1 blockade confer distinct immunological effects. To begin, the researchers examined bone marrow-derived mouse macrophages treated with...

The cell types behind the synergy in dual checkpoint blockade

August 8, 2018

Dual checkpoint blockade targeting PD-1 and CTLA-4 is one of the most effective immunotherapeutic strategies in the clinic, but while the mechanisms of action of each monotherapy have been studied in detail, the mechanism behind the synergy of this dynamic duo is not fully understood. In a recent study, published in Cancer Immunology...

T cell residency status affects prognosis in breast cancer

August 1, 2018

Inspired by the knowledge that the quantity of tumor-infiltrating lymphocytes (TILs) is prognostic for improved survival in breast cancer (BC) patients, particularly those with triple-negative (TNBC) and HER2-overexpressing (HER2+) subtypes, Savas and Virassamy et al., as described in Nature Medicine, set out to uncover whether specific T cell subpopulations affect prognosis in BC...