2022
April
Inducing optimal antitumor T cells by combining vaccination and checkpoint therapy
April 27, 2022
Tumor neoantigen-specific T cells generated by vaccines can synergize with immune checkpoint blockade (ICB) for antitumor efficacy, but not much is known about the dynamics of these cells during therapy. Therefore, Liu, Chen, and Zhang et al. assessed the tumor microenvironment (TME) and lymphatic organs in response to this treatment strategy in a...
AACR Annual Meeting 2022
April 20, 2022
Last week, the ACIR team attended the AACR Annual Meeting 2022 in New Orleans, LA. This week’s extensive special feature covers select talks from the conference. We have organized the content by topics below. T cell therapiesRobbie MajznerJohn HaanenMarcela MausNoam LevinAngela Aznar Cancer vaccination strategies and vaccine-elicited antibodies Leila DelamarreMichelle McKeague T cell...
Using Listeria bacteria as a trojan horse to treat pancreatic cancer
April 6, 2022
Pancreatic ductal adenocarcinoma (PDAC) poses challenges for immunotherapy due to its low immunogenicity and highly immunosuppressive environment. To overcome these issues, Selvanesan, Chandra, and Quispe-Tintaya et al. developed a microbial-based treatment to deliver an immunogenic protein into tumor cells to trigger antitumor responses. Their results were recently published in Science Translational Medicine. The researchers...
