Weekly Digests

2019

June

4-1BB agonism that only works on site

June 26, 2019

4-1BB plays an important role in the costimulation of T cells and is an attractive target for immunotherapy, however, clinical targeting of 4-1BB using agonistic antibodies has been plagued by either low potency or off-target liver toxicity due to Fcγ receptor (FcγR)-mediated cross-linking. To overcome these challenges and induce tumor-localized T cell costimulation...

Tumor infiltration is governed by CCL5 and CXCL9

June 19, 2019

Patients whose tumors are strongly infiltrated by immune cells tend to have a better prognosis and better responses to immunotherapy, but the mechanisms that underlie immune infiltration are not clearly defined. To better understand the infiltration of T cells into tumors, Dangaj et al. investigated the roles of chemokines in the tumor microenvironment...

Tregs eat costimulatory ligands to prevent T cell activation

June 12, 2019

It is well-known that Tregs suppress T cell responses to self-peptides via the CTLA-4 pathway in order to maintain normal immune homeostasis, but the details of this mechanism have not been fully elucidated. In vitro studies have shown that Tregs suppress the CD28-dependent activation of naive T cells by limiting their access to...

Multispecific antibodies set the rules of engagement for NK cell-mediated tumor control

June 5, 2019

Many bispecific T-cell engager antibodies have been developed and tested in recent years, but challenges with off-target toxicities and lack of efficacy against solid tumors remain. Instead of targeting T cells for antitumor immunity, Gauthier et al. designed and developed trifunctional NK-cell engagers (NKCEs) with the goal of reducing off-target cytotoxicity and enabling...

Close Modal

Small change for you. Big change for us!

This Thanksgiving season, show your support for cancer research by donating your change.

In less than a minute, link your credit card with our partner RoundUp App.

Every purchase you make with that card will be rounded up and the change will be donated to ACIR.

All transactions are securely made through Stripe.