Weekly Digests

2018

June

Neoepitope-reactive T cells achieve complete tumor regression in metastatic breast cancer

June 20, 2018

In a paper recently published in Nature Medicine, Zacharakis et al. report the case of a 49-year-old woman with estrogen receptor (ER)-positive, HER2-negative metastatic breast cancer, refractory to multiple lines of chemotherapy, who was enrolled in a phase II clinical trial that evaluated the efficacy of autologous tumor-infiltrating lymphocytes (TILs) in reducing tumor...

Liver cancer, immunity, and the microbiome: connecting the dots

June 13, 2018

The gut microbiome has recently emerged as a critical regulator of antitumor immunity. Nearby, the liver is supplied by blood largely from the intestines, meaning that it is directly exposed to the runoff of metabolites and other products of the microbiome. Noting this direct physical relationship, Ma et al. set out to determine...

The many faces of an exhausted T cell

June 6, 2018

Chronic diseases, such as HIV and cancer, are typically associated with an “exhausted” class of T cells characterized by poor function in disease control. Based on the hypothesis that a better understanding of the phenotypic variation among exhausted T cells may more effectively guide immunotherapy approaches, Bengsch et al. set out to systematically...