2024
August
Promoting systemic immunity with only local cytokine delivery
August 21, 2024
Cytokine therapy holds great promise in the oncology field, yet its application has been hindered by serious on-target, off-tumor effects. As a result, engineering approaches to confine cytokine activity to the tumor site have garnered considerable interest. Although advances in delivery methods have opened the intratumoral (i.t.) route as a viable option, rapid...
Restoring youth in DCs with hyperactivating vaccine adjuvant
August 14, 2024
Aging results in decreased immune system functionality, with age-associated changes to dendritic cells (DCs) limiting their migration and cytokine production. Given that such effects may induce immunotherapy resistance, Zhivaki et al. investigated a strategy with vaccine adjuvants to overcome these changes to DCs in murine models. Their research was recently published in Cell...
It’s not just Tregs – CD4+ Tr1 cells suppress antitumor immunity too
August 7, 2024
Regulatory T cells (Tregs) are the best known immunosuppressive CD4+ T cell subset, but Tr1 T cells, which are CD4+Foxp3- and marked by high expression of IL-10, are also known to maintain tolerance in autoimmunity and chronic infections. In recent work, Sultan et al. identified a population of Tr1 cells in tumors that...
