Weekly Digests

2026

March

Neoantigen vaccination boosts long-lasting T cell responses in TNBC

March 11, 2026

Triple-negative breast cancer (TNBC) is characterized by DNA repair deficiency, genomic instability, and an immunogenic tumor microenvironment, suggesting it might serve as a candidate for individualized vaccination targeting somatic tumor mutation-associated neoantigens. Sahin, Schmidt, et al. recently published the results of a first-in-human clinical study with this strategy in Nature. To develop the...

AACR IO 2026

March 4, 2026

The ACIR team attended the AACR IO meeting held on February 18-21, 2026 in Los Angeles, CA, USA. This week’s extensive special feature covers select talks from the conference. We have organized the content by topics below. T cellsPhilip D. GreenbergRafi AhmedFred RamsdellAlexander MarsonRobert G. NewmanOwen N. Witte Checkpoint blockadeFathia Mami-ChouaiDario A. VignaliMegan...

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