Weekly Digests

2017

March

Antigen presentation profiling reveals recognition of lymphoma immunoglobulin neoantigens

March 29, 2017

In an effort to discover new therapeutically useful neoantigen targets, Khodadoust et al. used new tools and found evidence for an “old” idea. In this study, the team took an integrated genomic and proteomic approach to mantle cell lymphoma from 17 untreated patients to explore the peptides presented by MHC class I and...

Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection

March 1, 2017

When it comes to controlling CARs it’s best to keep both hands on the wheel. In an effort to increase control in CAR T cell engineering, Eyquem et al. have utilized the CRISPR/Cas9 method to deliberately place a CD19-specific CAR coding sequence at the TRAC locus. The goal of this genetic modification was...