Weekly Digests

2026

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DC cross-presentation of dead cell F-actin antigens sculpts tumor evolution

January 14, 2026

Type 1 conventional dendritic cells (cDC1s) cross-present tumor antigens to prime CD8+ T cells. DNGR-1 on cDC1s binds to F-actin of dead cells to allow for detection and internalization of necrotic debris, and signaling results in MHC-I processing and presentation of antigens from the dead cells. In a recent publication in Nature Immunology...

Friend or foe? EPOR helps cDC1s make the call

January 7, 2026

The priming of an immune response is a complex process that is largely dependent on the functional state of cDC1s, which can induce either immunogenic or tolerogenic priming, depending on a number of conditions. While numerous factors associated with antigen uptake and presentation have been linked to different immune outcomes, the mechanisms that...

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