Weekly Digests

2018

January

Orphans no more: a new strategy for identifying the antigen targets of TCRs

January 10, 2018

The task of identifying the ligand that stimulates a specific T cell receptor (TCR) is one that has proven incredibly complex due to the vast diversity in the TCR, human leukocyte antigens (HLA), and peptide components. While powerful methods such as mass spectrometry or epitope prediction algorithms can narrow the list of possibilities...

Targeting glioma and sparing the brain: a transgenic TCR approach

January 3, 2018

For children with diffuse intrinsic pontine glioma (DIPG), current treatment does not offer much hope – median survival is less than 10 months. Chheda et al. aspire to improve this outlook by targeting glioma with immunotherapy. In their paper, published in Journal of Experimental Medicine, the researchers developed a transgenic TCR T cell...